Stabilization and encapsulation of photosensitive resveratrol within yeast cell.

Guorong Shi, Liqun Rao, Huazhong Yu, Hua Xiang, Hua Yang, Runa Ji
Author Information
  1. Guorong Shi: College of Biological and Technology, Hunan Agricultural University, Changsha 410128, PR China. shiguorong@56.com

Abstract

The photosensitive resveratrol was successfully encapsulated in yeast cells for the first time, as characterized by FT-IR spectra, fluorescence and confocal micrographs of the yeast cells, resveratrol and microcapsules. The release characteristic of the obtained yeast-encapsulated resveratrol in simulated gastric fluid was evaluated, and its storage stability as a powder was investigated at 25 degrees C/75% relative humidity (RH), 25 degrees C/90% RH and 60 degrees C under the laboratory fluorescent lighting conditions (ca. 300 lx) or in the dark. Also, the scavenging capacity of yeast-encapsulated resveratrol on DPPH radical was compared with that of non-encapsulated resveratrol. It could be demonstrated clearly that no chemical changes occurred during the encapsulation. Besides, the DPPH radical-scavenging activity increased after the encapsulation. In addition, the yeast-encapsulated resveratrol exhibited good stability, and its bioavailability was enhanced as a result of increased solubility of resveratrol and sustained releasing.

MeSH Term

Biological Availability
Biphenyl Compounds
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Delayed-Action Preparations
Drug Compounding
Drug Stability
Drug Storage
Free Radical Scavengers
Hot Temperature
Light
Microscopy, Confocal
Microscopy, Fluorescence
Particle Size
Picrates
Powders
Resveratrol
Saccharomyces cerevisiae
Solubility
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Stilbenes

Chemicals

Biphenyl Compounds
Delayed-Action Preparations
Free Radical Scavengers
Picrates
Powders
Stilbenes
1,1-diphenyl-2-picrylhydrazyl
Resveratrol

Word Cloud

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