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Antimicrobial agents and chemotherapy
Feb, 2008;52 (2): 735-8.

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.

Dimitrios P Kontoyiannis, Russell E Lewis, Barbara D Alexander, Olivier Lortholary, Françoise Dromer, Krishan L Gupta, George T John, Ramon Del Busto, Goran B Klintmalm, Jyoti Somani, G Marshall Lyon, Kenneth Pursell, Valentina Stosor, Patricia Munoz, Ajit P Limaye, Andre C Kalil, Timothy L Pruett, Julia Garcia-Diaz, Atul Humar, Sally Houston, Andrew A House, Dannah Wray, Susan Orloff, Lorraine A Dowdy, Robert A Fisher, Joseph Heitman, Nathaniel D Albert, Marilyn M Wagener, Nina Singh
Author Information
  1. Dimitrios P Kontoyiannis: M. D. Anderson Cancer Center, University of Texas, Houston, Texas 77030-3930, USA. dkontoyi@mdanderson.org
PMID: 18070977 DOI: 10.1128/AAC.00990-07

Abstract

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

References

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Grants

  1. R01 AI054719/NIAID NIH HHS
  2. R01 AI 054719-01/NIAID NIH HHS

MeSH Term

Antifungal Agents
Calcineurin Inhibitors
Cryptococcosis
Cryptococcus neoformans
Drug Synergism
Humans
Immunosuppressive Agents
Microbial Sensitivity Tests
Organ Transplantation
Tacrolimus
Treatment Outcome

Chemicals

Antifungal Agents
Calcineurin Inhibitors
Immunosuppressive Agents
Tacrolimus
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 10

Word Cloud

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