OpenLB
Open Library of Bioscience
Advanced Search
Antiviral research
Apr, 2008;78 (1): 162-9.

Treatment of hantavirus pulmonary syndrome.

Colleen B Jonsson, Jay Hooper, Gregory Mertz
Author Information
  1. Colleen B Jonsson: Department of Biochemistry and Molecular Biology, 2000 9th Avenue South, Southern Research Institute, Birmingham, AL 35205, United States. Jonsson@sri.org
PMID: 18093668 DOI: 10.1016/j.antiviral.2007.10.012

Abstract

Viruses in the genus Hantavirus can cause one of two serious illnesses when transmitted from rodents to humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Of the two diseases, HPS is more severe with an approximate 40% mortality across the Americas. The high rate of mortality could be reduced if effective therapeutics could be discovered for treatment of this illness. Herein we review approaches being explored for the discovery of therapeutics for HPS and how they could be employed in treatment and prevention of disease.

References

  1. Emerg Infect Dis. 2004 Sep;10(9):1635-42 [PMID: 15498167]
  2. J Virol. 2007 Jul;81(14):7449-62 [PMID: 17475651]
  3. Virology. 1998 Feb 15;241(2):323-30 [PMID: 9499807]
  4. Clin Infect Dis. 2004 Nov 1;39(9):1307-13 [PMID: 15494907]
  5. Clin Infect Dis. 2002 May 1;34(9):1224-31 [PMID: 11941549]
  6. Infect Dis Clin North Am. 1998 Mar;12(1):95-110 [PMID: 9494832]
  7. Clin Infect Dis. 1995 Sep;21(3):643-9 [PMID: 8527558]
  8. Emerg Infect Dis. 1997 Jul-Sep;3(3):361-5 [PMID: 9284382]
  9. J Virol. 2003 Jan;77(2):1540-50 [PMID: 12502867]
  10. Viral Immunol. 2004;17(4):481-97 [PMID: 15671746]
  11. Radiology. 1994 Jun;191(3):665-8 [PMID: 8184043]
  12. Nature. 1997 Mar 27;386(6623):320 [PMID: 9121542]
  13. Am J Pathol. 1995 Mar;146(3):552-79 [PMID: 7887439]
  14. J Infect Dis. 2007 May 15;195(10):1541-9 [PMID: 17436235]
  15. Curr Top Microbiol Immunol. 2001;256:117-34 [PMID: 11217400]
  16. Chin Med J (Engl). 1989 Feb;102(2):116-9 [PMID: 2570679]
  17. J Infect Dis. 2000 Jul;182(1):43-8 [PMID: 10882580]
  18. Lancet. 1997 Apr 5;349(9057):998-9 [PMID: 9100632]
  19. Emerg Infect Dis. 2003 Jul;9(7):891-2 [PMID: 12899143]
  20. J Virol. 2003 Sep;77(18):9894-905 [PMID: 12941899]
  21. Biochem Biophys Res Commun. 2002 Nov 8;298(4):552-8 [PMID: 12408987]
  22. J Virol. 2001 Feb;75(4):1808-15 [PMID: 11160679]
  23. J Med Microbiol. 2000 Feb;49(2):149-155 [PMID: 10670565]
  24. Arch Virol. 1992;126(1-4):271-81 [PMID: 1381911]
  25. Adv Virus Res. 2001;57:105-36 [PMID: 11680383]
  26. Virology. 1999 Mar 15;255(2):269-78 [PMID: 10069952]
  27. Curr Top Microbiol Immunol. 2001;256:47-75 [PMID: 11217406]
  28. Int J Epidemiol. 1988 Dec;17(4):887-90 [PMID: 2906333]
  29. J Infect Dis. 2006 Nov 15;194(10):1403-9 [PMID: 17054070]
  30. Am J Trop Med Hyg. 1997 Sep;57(3):274-82 [PMID: 9311636]
  31. J Infect Dis. 1982 Nov;146(5):645-51 [PMID: 6127367]
  32. J Virol. 2002 Jul;76(13):6669-77 [PMID: 12050380]
  33. Arch Virol. 1989;105(3-4):235-46 [PMID: 2568827]
  34. Vaccine. 2002 Oct 4;20(29-30):3523-31 [PMID: 12297397]
  35. J Infect Dis. 2002 Nov 15;186(10):1390-5 [PMID: 12404153]
  36. J Virol. 1999 May;73(5):3951-9 [PMID: 10196290]
  37. J Med Virol. 1985 Oct;17(2):107-17 [PMID: 2865331]
  38. Annu Rev Med. 1999;50:531-45 [PMID: 10073292]
  39. Am J Trop Med Hyg. 1992 Oct;47(4):397-404 [PMID: 1359802]
  40. Virology. 1996 Jun 1;220(1):223-6 [PMID: 8659118]
  41. Curr Opin Infect Dis. 2006 Oct;19(5):437-42 [PMID: 16940866]
  42. Clin Infect Dis. 1996 May;22(5):824-6 [PMID: 8722939]
  43. Am J Med Sci. 2002 Jun;323(6):316-25 [PMID: 12074486]
  44. J Gen Virol. 2007 Feb;88(Pt 2):493-505 [PMID: 17251568]
  45. Viral Immunol. 2006 Summer;19(3):558-64 [PMID: 16987073]
  46. Virology. 2001 Oct 10;289(1):6-14 [PMID: 11601912]
  47. Emerg Infect Dis. 2006 Aug;12(8):1271-3 [PMID: 16965713]
  48. Science. 1993 Nov 5;262(5135):914-7 [PMID: 8235615]
  49. Lancet Infect Dis. 2003 Oct;3(10):653-61 [PMID: 14522264]
  50. J Virol. 1990 Jul;64(7):3162-70 [PMID: 1972201]
  51. J Med Virol. 2000 Jan;60(1):77-85 [PMID: 10568767]
  52. Virology. 2006 Dec 5-20;356(1-2):45-9 [PMID: 16950493]
  53. Prog Med Virol. 1989;36:62-102 [PMID: 2573914]
  54. Vaccine. 2007 Feb 19;25(9):1690-9 [PMID: 17110000]
  55. Panminerva Med. 2003 Mar;45(1):43-51 [PMID: 12682619]
  56. Virology. 2000 Nov 10;277(1):14-9 [PMID: 11062031]
  57. Vaccine. 2004 Sep 28;22(29-30):4029-34 [PMID: 15364453]
  58. Emerg Infect Dis. 2005 Dec;11(12):1848-53 [PMID: 16485469]
  59. Emerg Infect Dis. 1997 Apr-Jun;3(2):95-104 [PMID: 9204290]
  60. Virology. 1996 Mar 1;217(1):262-71 [PMID: 8599211]
  61. J Infect Dis. 2004 Nov 1;190(9):1708-10 [PMID: 15478081]
  62. J Infect Dis. 1983 Dec;148(6):1005-12 [PMID: 6140290]
  63. J Virol. 2005 Jun;79(12):7319-26 [PMID: 15919886]
  64. Lancet. 1996 Jan 6;347(8993):57 [PMID: 8531560]
  65. Arch Virol. 1988;101(1-2):125-30 [PMID: 3137914]
  66. J Virol. 2001 Sep;75(18):8469-77 [PMID: 11507192]
  67. J Med Virol. 1999 Dec;59(4):527-35 [PMID: 10534737]
  68. Am J Trop Med Hyg. 2000 Jun;62(6):714-7 [PMID: 11304061]
  69. J Infect Dis. 1987 Dec;156(6):1010-3 [PMID: 2890690]
  70. Semin Respir Infect. 1997 Mar;12(1):31-9 [PMID: 9097374]
  71. J Infect Dis. 1986 Mar;153(3):489-97 [PMID: 2869089]
  72. J Hosp Infect. 1998 Dec;40(4):281-5 [PMID: 9868619]
  73. J Gen Virol. 2002 Jul;83(Pt 7):1745-1751 [PMID: 12075094]
  74. Medicina (B Aires). 1996;56(6):709-11 [PMID: 9284576]
  75. J Gen Virol. 1986 Dec;67 ( Pt 12):2819-24 [PMID: 2878971]
  76. Virology. 2006 Mar 30;347(1):208-16 [PMID: 16378630]
  77. J Infect Dis. 2002 Dec 15;186(12):1706-12 [PMID: 12447754]
  78. Crit Care Med. 1996 Feb;24(2):252-8 [PMID: 8605797]
  79. J Infect Dis. 2007 Jun 1;195(11):1563-71 [PMID: 17471425]
  80. Infect Immun. 1983 Jul;41(1):391-8 [PMID: 6134678]
  81. Am J Trop Med Hyg. 2006 Dec;75(6):1127-34 [PMID: 17172380]
  82. Virology. 1997 Nov 10;238(1):115-27 [PMID: 9375015]
  83. Vaccine. 2001 Jul 16;19(28-29):3820-9 [PMID: 11427253]
  84. J Virol. 2002 Apr;76(8):3765-73 [PMID: 11907216]
  85. Antivir Ther. 1999;4(4):211-9 [PMID: 10723500]
  86. J Infect Dis. 1995 Jul;172(1):38-44 [PMID: 7797944]
  87. Virus Res. 1997 Oct;51(2):159-71 [PMID: 9498614]
  88. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7074-9 [PMID: 9618541]
  89. Arch Virol. 2004 Jul;149(7):1325-39 [PMID: 15221534]
  90. J Infect Dis. 1991 Dec;164(6):1119-27 [PMID: 1683355]
  91. Vaccine. 2005 Jun 10;23(30):3973-83 [PMID: 15917119]
  92. Prog Med Virol. 1982;28:96-113 [PMID: 6124025]
  93. Vaccine. 2006 Apr 5;24(15):2928-34 [PMID: 16426712]

Grants

  1. R21 AI064499/NIAID NIH HHS
  2. R21 AI064499-01/NIAID NIH HHS
  3. R21 AI064499-02/NIAID NIH HHS

MeSH Term

Animals
Antiviral Agents
Cricetinae
Disease Models, Animal
Orthohantavirus
Hantavirus Pulmonary Syndrome
Humans
Immunotherapy
Mice
Radiography
Rats
Ribavirin

Chemicals

Antiviral Agents
Ribavirin
Journal Article Review
Article has an altmetric score of 19

Word Cloud

Created with Highcharts 10.0.0syndromeHPStwohantaviruspulmonarymortalitytherapeuticstreatmentVirusesgenusHantaviruscancauseoneseriousillnessestransmittedrodentshumans:hemorrhagicfeverrenalHFRSdiseasessevereapproximate40%acrossAmericashighratereducedeffectivediscoveredillnessHereinreviewapproachesexploreddiscoveryemployedpreventiondiseaseTreatment

Similar Articles

Cited By