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European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Aug, 2008;265 (8): 917-22.

Expression of epidermal growth factor receptor in the inverted papilloma and squamous cell carcinoma of nasal cavity.

Jiung-Chih Chao, Sheen-Yie Fang
Author Information
  1. Jiung-Chih Chao: Department of Otolaryngology, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan 704, Taiwan. chaojc@mail.ncku.edu.tw
PMID: 18231801 DOI: 10.1007/s00405-008-0582-3

Abstract

The present study was undertaken to compare positive rate of immunostaining (PR) and positive intensity of immunostaining (PI) of epidermal growth factor receptor (EGFR) in inverted papilloma (IP), synchronous carcinoma with IP and metachronous carcinoma with IP of the nasal cavity. Ten subjects with nasal polyps, ten subjects with inverted papilloma (IP), five subjects with synchronous carcinoma with IP and ten subjects with metachronous carcinoma with IP were enrolled with a control group of ten subjects of inferior turbinate. Each specimen was divided into two portions: one for RNA isolation and the other for detection of EGFR protein. Positive rate of immunostaining, positive intensity of immunostaining for EGFR protein and EGFR mRNA were significantly up-regulated in the IP, synchronous carcinoma with IP and metachronous carcinoma with IP when comparing polyp and normal mucosa. A role for EGFR in the malignant transformation from IP to SCC of the nasal cavity is suggested.

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MeSH Term

Carcinoma, Squamous Cell
Cell Transformation, Neoplastic
ErbB Receptors
Humans
Immunohistochemistry
Nasal Cavity
Neoplasms, Multiple Primary
Neoplasms, Second Primary
Nose Neoplasms
Papilloma, Inverted
Reverse Transcriptase Polymerase Chain Reaction

Chemicals

ErbB Receptors
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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