OpenLB
Open Library of Bioscience
Advanced Search
Antimicrobial agents and chemotherapy
Aug, 2008;52 (8): 2947-9.

Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism.

Fernanda S Spies, Pedro E Almeida da Silva, Marta O Ribeiro, Maria Lucia Rossetti, Arnaldo Zaha
Author Information
  1. Fernanda S Spies: Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
PMID: 18541729 DOI: 10.1128/AAC.01570-07

Abstract

The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL, rrs, and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.

References

  1. J Med Microbiol. 2004 Feb;53(Pt 2):107-113 [PMID: 14729930]
  2. Antimicrob Agents Chemother. 2002 Aug;46(8):2720-2 [PMID: 12121966]
  3. Mol Microbiol. 1993 Sep;9(6):1239-46 [PMID: 7934937]
  4. FEMS Microbiol Rev. 2000 Oct;24(4):449-67 [PMID: 10978546]
  5. J Antimicrob Chemother. 1999 Feb;43(2):281-4 [PMID: 11252336]
  6. Res Microbiol. 2004 Dec;155(10):830-4 [PMID: 15567277]
  7. Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S4-10 [PMID: 10688142]
  8. Antimicrob Agents Chemother. 1996 Nov;40(11):2673-4 [PMID: 8913490]
  9. Antimicrob Agents Chemother. 2002 Sep;46(9):2804-10 [PMID: 12183232]
  10. Biochem Biophys Res Commun. 1996 Sep 13;226(2):362-8 [PMID: 8806641]
  11. Int J Tuberc Lung Dis. 2004 Aug;8(8):1032-5 [PMID: 15305490]
  12. Mol Microbiol. 2005 Mar;55(6):1829-40 [PMID: 15752203]
  13. Antimicrob Agents Chemother. 1996 Apr;40(4):1024-6 [PMID: 8849220]
  14. Mol Microbiol. 2007 Feb;63(4):1096-106 [PMID: 17238915]
  15. Antimicrob Agents Chemother. 2001 Mar;45(3):800-4 [PMID: 11181364]
  16. J Antimicrob Chemother. 2003 Jan;51(1):9-11 [PMID: 12493781]
  17. Antimicrob Agents Chemother. 1994 Feb;38(2):238-42 [PMID: 8192450]
  18. Antimicrob Agents Chemother. 1996 Nov;40(11):2452-4 [PMID: 8913445]
  19. Methods Enzymol. 1994;235:196-205 [PMID: 8057895]
  20. Antimicrob Agents Chemother. 2004 Aug;48(8):3175-8 [PMID: 15273144]
  21. Eur Respir J Suppl. 1995 Sep;20:701s-713s [PMID: 8590570]
  22. Mol Med. 2002 Nov;8(11):714-24 [PMID: 12520088]
  23. Emerg Infect Dis. 2003 Jul;9(7):838-45 [PMID: 12890325]
  24. Annu Rev Pharmacol Toxicol. 2005;45:529-64 [PMID: 15822188]

MeSH Term

Anti-Bacterial Agents
Bacterial Proteins
DNA Mutational Analysis
Humans
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis
Streptomycin
Tuberculosis
Tuberculosis, Multidrug-Resistant

Chemicals

Anti-Bacterial Agents
Bacterial Proteins
Streptomycin
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

Created with Highcharts 10.0.0streptomycinEPresistanceeffluxgidBpossibleSTRisolatesmutationsMICpresencepumpinhibitorssequencingrpsLrrsgenesprovidedevidenceparticipationlow-levelwithoutMutationgeneactsynergisticallyconferlowIdentificationrelatedclinicalMycobacteriumtuberculosisinvolvementmechanism

Similar Articles

Cited By