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Cancer imaging : the official publication of the International Cancer Imaging Society
Jun 30, 2008;8 135-45.

The effect of tamoxifen on the genital tract.

Sandra A Polin, Susan M Ascher
Author Information
  1. Sandra A Polin: Department of Radiology, Georgetown University Hospital, 3800 Reservoir Road, Washington, DC 20007, USA. sandrapolin@gmail.com
PMID: 18603495 DOI: 10.1102/1470-7330.2008.0020

Abstract

Tamoxifen is a selective estrogen receptor modulator (SERM) that is widely used in the treatment of patients with breast cancer and for chemoprophylaxis in high risk women. Tamoxifen results in a spectrum of abnormalities involving the genital tract, the most significant being an increased incidence of endometrial cancer and uterine sarcoma. This article reviews the effects of tamoxifen on the genital tract and the strengths and weaknesses of various imaging modalities for evaluating the endometrium.

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MeSH Term

Adult
Aged
Antineoplastic Agents, Hormonal
Breast Neoplasms
Cervix Uteri
Chemotherapy, Adjuvant
Dose-Response Relationship, Drug
Drug Administration Schedule
Endosonography
Female
Female Urogenital Diseases
Follow-Up Studies
Humans
Incidence
Magnetic Resonance Imaging
Middle Aged
Ovary
Risk Assessment
Tamoxifen
Vagina

Chemicals

Antineoplastic Agents, Hormonal
Tamoxifen
Journal Article Review
Article has an altmetric score of 14

Word Cloud

Created with Highcharts 10.0.0genitaltractTamoxifencancertamoxifenselectiveestrogenreceptormodulatorSERMwidelyusedtreatmentpatientsbreastchemoprophylaxishighriskwomenresultsspectrumabnormalitiesinvolvingsignificantincreasedincidenceendometrialuterinesarcomaarticlereviewseffectsstrengthsweaknessesvariousimagingmodalitiesevaluatingendometriumeffect

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