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Current opinion in infectious diseases
Oct, 2008;21 (5): 489-94.

New insights into Entamoeba histolytica pathogenesis.

Leigh A Baxt, Upinder Singh
Author Information
  1. Leigh A Baxt: Department of Microbiology and Immunology, Stanford University, Stanford, California, USA.
PMID: 18725798 DOI: 10.1097/QCO.0b013e32830ce75f

Abstract

PURPOSE OF REVIEW: Entamoeba histolytica is an important global pathogen and a leading cause of parasitic death worldwide. This article summarizes significant research findings over the last year.
RECENT FINDINGS: Efforts have focused primarily on identification of novel virulence determinants in E. histolytica, transcriptional profiling during tissue invasion and stage conversion, and characterization of basic cell biological processes. Additionally, new techniques for gene silencing have been identified.
SUMMARY: A comprehensive examination of the parasite lifestyle on a whole genome level has been undertaken, allowing identification of new virulence genes and signaling pathways and processes relevant to amebic biology.

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Grants

  1. R01 AI053724/NIAID NIH HHS
  2. R01 AI053724-05/NIAID NIH HHS
  3. T32 AI007328/NIAID NIH HHS

MeSH Term

Animals
DNA, Protozoan
Entamoeba histolytica
Entamoebiasis
Gene Expression Profiling
Genes, Protozoan
Genome, Protozoan
Oligonucleotide Array Sequence Analysis
Protozoan Proteins
Retroelements
Virulence

Chemicals

DNA, Protozoan
Protozoan Proteins
Retroelements
Journal Article Review
Article has an altmetric score of 6

Word Cloud

Created with Highcharts 10.0.0histolyticaEntamoebaidentificationvirulenceprocessesnewPURPOSEOFREVIEW:importantglobalpathogenleadingcauseparasiticdeathworldwidearticlesummarizessignificantresearchfindingslastyearRECENTFINDINGS:EffortsfocusedprimarilynoveldeterminantsEtranscriptionalprofilingtissueinvasionstageconversioncharacterizationbasiccellbiologicalAdditionallytechniquesgenesilencingidentifiedSUMMARY:comprehensiveexaminationparasitelifestylewholegenomelevelundertakenallowinggenessignalingpathwaysrelevantamebicbiologyNewinsightspathogenesis

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