Ten-membered lactones from the marine-derived fungus Curvularia sp.

Hendrik Greve, Peter J Schupp, Ekaterina Eguereva, Stefan Kehraus, Gabriele M König
Author Information
  1. Hendrik Greve: Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.

Abstract

Investigation of the secondary metabolites of the marine-derived fungus Curvularia sp. yielded four new 10-membered lactones (1-4), along with the known modiolide A (5). The structures of 1-4 were characterized on the basis of spectroscopic and MS data and resemble known 10-membered lactones, but feature modified oxidation patterns around their macrocycles.

Grants

  1. S06-GM-44796-16A/NIGMS NIH HHS

MeSH Term

Ascomycota
Lactones
Marine Biology
Microbial Sensitivity Tests
Molecular Structure
Rhodophyta

Chemicals

Lactones

Word Cloud

Created with Highcharts 10.0.0lactonesmarine-derivedfungusCurvulariasp10-membered1-4knownInvestigationsecondarymetabolitesyieldedfournewalongmodiolide5structurescharacterizedbasisspectroscopicMSdataresemblefeaturemodifiedoxidationpatternsaroundmacrocyclesTen-membered

Similar Articles

Cited By