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Paediatric drugs
2008;10 (6): 367-78.

Treatment strategies for methicillin-resistant Staphylococcus aureus infections in pediatrics.

Jason G Newland, Gregory L Kearns
Author Information
  1. Jason G Newland: Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri, USA. jnewland1@cmh.edu
PMID: 18998747 DOI: 10.2165/0148581-200810060-00004

Abstract

Staphylococcus aureus is an important pathogen that frequently causes clinical disease in children. A wide array of illnesses can be caused by this common pathogen ranging from non-invasive skin infections to severe, life-threatening sepsis. Additionally, as antibacterials have been used to eradicate S. aureus, it has developed resistance to these important therapeutic agents. methicillin-resistant S. aureus (MRSA) has become an increasing problem in pediatric patients over the past decade. In this review, we discuss the epidemiology, pathogenesis, and treatment options available in treating MRSA infections in children. Specifically, we address the importance of abscess drainage in the treatment of skin and soft tissue infections, the most common clinical manifestation of MRSA infections, and highlight the various agents that are available for treating this common infection. In severe, life-threatening invasive MRSA infections the primary therapeutic option is vancomycin. In cases of MRSA toxic shock syndrome the addition of clindamycin is necessary. In other invasive MRSA infections, such as pneumonia and musculoskeletal infections, the empiric treatment of choice is clindamycin. Finally, newer agents and additional treatment options are discussed.

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Grants

  1. 1 U10 HD31313-14/NICHD NIH HHS

MeSH Term

Anti-Bacterial Agents
Child
Humans
Methicillin-Resistant Staphylococcus aureus
Soft Tissue Infections
Staphylococcal Infections
Staphylococcal Skin Infections

Chemicals

Anti-Bacterial Agents
Journal Article Research Support, N.I.H., Extramural Review
Article has an altmetric score of 3

Word Cloud

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