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Cognitive processing
Feb, 2009;10 Suppl 1 S9-15.

Signaling in large-scale neural networks.

Rune W Berg, Jørn Hounsgaard
Author Information
  1. Rune W Berg: Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark.
PMID: 19009313 DOI: 10.1007/s10339-008-0238-7

Abstract

We examine the recent finding that neurons in spinal motor circuits enter a high conductance state during functional network activity. The underlying concomitant increase in random inhibitory and excitatory synaptic activity leads to stochastic signal processing. The possible advantages of this metabolically costly organization are analyzed by comparing with synaptically less intense networks driven by the intrinsic response properties of the network neurons.

References

  1. J Neurophysiol. 1992 Apr;67(4):961-80 [PMID: 1588394]
  2. J Neurosci. 2002 Dec 15;22(24):10790-800 [PMID: 12486172]
  3. J Cereb Blood Flow Metab. 2001 Oct;21(10):1133-45 [PMID: 11598490]
  4. Trends Neurosci. 1989 Sep;12(9):313-5 [PMID: 2480669]
  5. J Neurophysiol. 2005 Dec;94(6):4455-70 [PMID: 16148279]
  6. Science. 2006 Oct 6;314(5796):85-90 [PMID: 17023650]
  7. Biosystems. 2004 Aug-Oct;76(1-3):75-87 [PMID: 15351132]
  8. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Mar;191(3):213-29 [PMID: 15452660]
  9. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11569-73 [PMID: 1763072]
  10. Science. 1996 Dec 6;274(5293):1724-6 [PMID: 8939866]
  11. J Neurosci. 2005 Jul 6;25(27):6316-21 [PMID: 16000621]
  12. J Neurophysiol. 2001 May;85(5):1969-85 [PMID: 11353014]
  13. Nat Rev Neurosci. 2006 Mar;7(3):232-42 [PMID: 16495944]
  14. Nat Rev Neurosci. 2005 Nov;6(11):841-9 [PMID: 16261178]
  15. Nat Rev Neurosci. 2003 Jul;4(7):573-86 [PMID: 12838332]
  16. J Neurosci. 2003 Mar 15;23(6):2466-76 [PMID: 12657707]
  17. J Neurosci. 1993 Jan;13(1):334-50 [PMID: 8423479]
  18. J Neurosci. 1998 May 15;18(10):3870-96 [PMID: 9570816]
  19. Nat Rev Neurosci. 2003 Sep;4(9):739-51 [PMID: 12951566]
  20. Prog Brain Res. 1999;123:57-63 [PMID: 10635704]
  21. Nature. 1989 Sep 7;341(6237):52-4 [PMID: 2770878]
  22. J Neurosci. 2003 Sep 24;23(25):8625-9 [PMID: 14507961]
  23. Neural Comput. 1998 Aug 15;10(6):1321-71 [PMID: 9698348]
  24. Science. 1989 Jun 30;244(4912):1587-9 [PMID: 2740903]
  25. Science. 2007 Jan 19;315(5810):390-3 [PMID: 17234950]
  26. PLoS One. 2008 Sep 16;3(9):e3218 [PMID: 18795101]
  27. Trends Neurosci. 2007 Jul;30(7):334-42 [PMID: 17481741]
  28. Biol Cybern. 2006 Jul;95(1):1-19 [PMID: 16622699]
  29. J Neurosci. 2004 Mar 10;24(10):2345-56 [PMID: 15014109]
  30. Annu Rev Physiol. 2007;69:291-316 [PMID: 17009928]
  31. Science. 1988 Dec 23;242(4886):1654-64 [PMID: 3059497]
  32. Riv Biol. 2005 Jan-Apr;98(1):111-23 [PMID: 15889343]
  33. J Physiol Paris. 1995;89(4-6):195-208 [PMID: 8861818]
  34. Science. 1967 Feb 17;155(3764):842-4 [PMID: 6018196]
  35. Prog Biophys Mol Biol. 1999;72(4):329-65 [PMID: 10605293]
  36. Nat Neurosci. 2005 Feb;8(2):194-201 [PMID: 15665876]
  37. J Exp Biol. 2001 Apr;204(Pt 8):1413-9 [PMID: 11273803]
  38. Biophys J. 1964 Jan;4:41-68 [PMID: 14104072]
  39. Neuron. 2002 Aug 15;35(4):773-82 [PMID: 12194875]
  40. Annu Rev Neurosci. 2005;28:503-32 [PMID: 16033324]
  41. Fed Proc. 1975 Apr;34(5):1398-407 [PMID: 164391]
  42. J Neurocytol. 1996 Dec;25(12):735-46 [PMID: 9023721]
  43. Annu Rev Physiol. 1985;47:29-48 [PMID: 2986532]
  44. J Neurosci. 2007 Dec 12;27(50):13802-12 [PMID: 18077692]
  45. J Neurophysiol. 1990 Oct;64(4):1134-48 [PMID: 2258738]
  46. J Neurosci. 2006 Apr 26;26(17):4535-45 [PMID: 16641233]
  47. Trends Neurosci. 2005 Oct;28(10):534-40 [PMID: 16112756]

MeSH Term

Animals
Chromosome Pairing
Humans
Nerve Net
Neurons
Signal Transduction
Journal Article Review

Word Cloud

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