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Behavioral neuroscience
Feb, 2009;123 (1): 218-23.

Peripheral delivery of a ROCK inhibitor improves learning and working memory.

Matthew J Huentelman, Dietrich A Stephan, Joshua Talboom, Jason J Corneveaux, David M Reiman, Jill D Gerber, Carol A Barnes, Gene E Alexander, Eric M Reiman, Heather A Bimonte-Nelson
Author Information
  1. Matthew J Huentelman: Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85004, USA. mhuentelman@tgen.org
PMID: 19170447 DOI: 10.1037/a0014260

Abstract

Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.

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Grants

  1. R01 NS059873-01A1/NINDS NIH HHS
  2. P30 AG019610/NIA NIH HHS
  3. R01 NS059873/NINDS NIH HHS
  4. NS059873/NINDS NIH HHS
  5. AG19610/NIA NIH HHS

MeSH Term

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Aging
Animals
Dose-Response Relationship, Drug
Male
Maze Learning
Memory, Short-Term
Rats
Rats, Inbred F344
rhoA GTP-Binding Protein

Chemicals

hydroxyfasudil
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
rhoA GTP-Binding Protein
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 28

Word Cloud

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