Differential expression of sigH paralogs during growth and under different stress conditions in Mycobacterium smegmatis.
Anirudh K Singh, Bhupendra N Singh
Author Information
Anirudh K Singh: Division of Microbiology, Central Drug Research Institute, Lucknow 226 001, India. bhupendransingh@gmail.com
SigH regulates a transcriptional network that responds to heat and oxidative stress in mycobacteria. Seven sigH paralogs are reported to exist in the Mycobacterium smegmatis genome. A comprehensive real-time reverse transcriptase PCR analysis during different stages of growth and upon exposure to various stress conditions and antimycobacterial compounds showed differential expression of sigH paralogs during stationary phase and severalfold increases in the levels of transcription of sigH1, sigH4, sigH5, sigH6, and sigH7 under specific stress conditions.
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Antitubercular Agents
Bacterial Proteins
Gene Expression Profiling
Gene Expression Regulation, Bacterial
Gene Order
Genes, Bacterial
Hot Temperature
Mycobacterium smegmatis
Oxidative Stress
Protein Isoforms
Sigma Factor
Antitubercular Agents
Bacterial Proteins
Protein Isoforms
SigH protein, bacteria
Sigma Factor
