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The American journal of tropical medicine and hygiene
Jun, 2009;80 (6): 902-4.

Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea.

Kesinee Chotivanich, Jetsumon Sattabongkot, Yien Kyong Choi, Jae Sun Park, Juntima Sritabal, Chae Seung Lim, Rachanee Udomsangpetch, Nicholas J White, Won Ja Lee
Author Information
  1. Kesinee Chotivanich: Faculty of Tropical Medicine, and Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
PMID: 19478246

Abstract

The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC(50)) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL, pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, P = 0.004), piperaquine and chloroquine (r = 0.6, P = 0.008), and piperaquine and primaquine IC(50) values (r = 0.5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate.

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Grants

  1. /Wellcome Trust
  2. 090207/Z/09/Z/Wellcome Trust

MeSH Term

Animals
Antimalarials
Drug Resistance
Humans
Inhibitory Concentration 50
Korea
Parasitic Sensitivity Tests
Plasmodium vivax

Chemicals

Antimalarials
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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