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Biochimica et biophysica acta
2010 Jan-Feb;1799 (1-2): 3-14.

Nuclear functions of the HMG proteins.

Raymond Reeves
Author Information
  1. Raymond Reeves: School of Molecular Biosciences, Washington State University, Biotechnology/Life Sciences Bldg., Rm. 143, Pullman, WA 99164-7520, USA. reevesr@wsu.edu
PMID: 19748605 DOI: 10.1016/j.bbagrm.2009.09.001

Abstract

Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses on the similarities and differences in the mechanisms by which the different HMG families impact chromatin structure and influence cellular phenotype. The biological implications of having three architectural transcription factor families with complementary, but partially overlapping, nuclear functions are discussed.

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Grants

  1. R01 GM071760/NIGMS NIH HHS
  2. R01 GM071760-04/NIGMS NIH HHS
  3. R01-GM071760/NIGMS NIH HHS

MeSH Term

Animals
Cell Nucleus
HMGA Proteins
HMGB Proteins
HMGN Proteins
High Mobility Group Proteins
Humans
Nucleosomes

Chemicals

HMGA Proteins
HMGB Proteins
HMGN Proteins
High Mobility Group Proteins
Nucleosomes
Journal Article Research Support, N.I.H., Extramural Review
Article has an altmetric score of 3

Word Cloud

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