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Journal of biomedicine & biotechnology
2009;2009 594738.

An evolutionary perspective of animal microRNAs and their targets.

Noam Shomron, David Golan, Eran Hornstein
Author Information
  1. Noam Shomron: Department of Cell & Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. nshomron@post.tau.ac.il
PMID: 19759918 DOI: 10.1155/2009/594738

Abstract

MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting approximately 50% of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs.

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MeSH Term

Animals
Evolution, Molecular
MicroRNAs
RNA, Messenger

Chemicals

MicroRNAs
RNA, Messenger
Journal Article Research Support, Non-U.S. Gov't Review

Word Cloud

Created with Highcharts 10.0.0miRNAmRNAtargetregulationgenesoftentargetsmRNAsanimalMicroRNAsmiRNAsshortnoncodingRNAsregulategeneexpressiontranslationalinhibitiondegradationbindingsequencesappearsabundantmodeposttranscriptionalaffectingapproximately50%transcriptomeclusteredand/orlocatedintronsvariablelargenumberdiscussgenomicarchitectureevolvinginteractionevolutionaryperspectivemicroRNAs

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