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BMC cancer
Nov 11, 2009;9 394.

B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population.

Jie Zhang, Mingyan Zhang, Wei Jiang, Lihong Wang, Zhenkun Fu, Dalin Li, Da Pang, Dianjun Li
Author Information
  1. Jie Zhang: Department of Immunology, Harbin Medical University, Harbin, Heilongjiang, PR China. zjsxzj.029@gmail.com
PMID: 19903360 DOI: 10.1186/1471-2407-9-394

Abstract

BACKGROUND: B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal tissues, and has a potential effect to protect tumors from anti-tumor immune responses. This case-control study was carried out to determine the potential influences of B7-H4 gene polymorphisms on the susceptibility and progression of breast cancer in Han women of Northeast China.
METHODS: We genotyped three B7-H4 variants (rs10754339, rs10801935 and rs3738414) and tagged all common haplotypes (frequency greater than or equal to 1%) in a Chinese population consisting of 500 breast cancer cases and 504 control individuals matched for age. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the genotypes.
RESULTS: Our data indicated that, compared with the common genotype and allele of each SNP, the rs10754339 AG genotype and G allele showed a significantly increased risk of breast cancer (OR = 1.455, 95% CI 1.119-1.892; OR = 1.325, 95% CI 1.073-1.637, respectively). The rs10801935 CC genotype, the rs3738414 AA genotype and the rs3738414 A allele were associated with a significantly decreased risk of breast cancer (OR = 0.328, 95% CI 0.145-0.739; OR = 0.412, 95% CI 0.203-0.835; OR = 0.698, 95% CI 0.564-0.864, respectively). Additionally, the rs10754339 GG genotype was significantly associated with lymph node metastasis and PR status, and the G allele and the AG genotype were respectively associated with lymph node metastasis and ER status. In haplotype analysis, we observed that compared with the AAG haplotype, the AAA haplotype showed a significantly decreased risk of breast cancer (OR = 0.689, 95% CI 0.539-0.881), but the GAG haplotype was associated with a significantly increased risk of breast cancer (OR = 1.511, 95% CI 1.125-2.031). And the AAA and the GCG haplotypes also respectively have significant influences on tumor size and ER status.
CONCLUSION: These results suggest that B7-H4 gene polymorphism may contribute to the sporadic breast cancer risk and prognosis in Chinese Han women.

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MeSH Term

Asian People
B7-1 Antigen
Breast Neoplasms
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Prognosis
Risk Factors
V-Set Domain-Containing T-Cell Activation Inhibitor 1

Chemicals

B7-1 Antigen
V-Set Domain-Containing T-Cell Activation Inhibitor 1
VTCN1 protein, human
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

Created with Highcharts 10.0.0breastcancer0OR=95%CIB7-H4genotype1significantlyriskassociatedallelerespectivelyhaplotypegeneHanrs10754339rs3738414Chinesestatustumortissuespotentialdetermineinfluencespolymorphismswomenrs10801935commonhaplotypespopulationpolymorphismcomparedAGGshowedincreaseddecreasedlymphnodemetastasisERAAAsporadicBACKGROUND:co-inhibitorymoleculeB7familycanrestrainTcellproliferationcytokinesecretiondevelopmentcytotoxicityexpressedhigherlevelnormaleffectprotecttumorsanti-tumorimmuneresponsescase-controlstudycarriedsusceptibilityprogressionNortheastChinaMETHODS:genotypedthreevariantstaggedfrequencygreaterequal1%consisting500cases504controlindividualsmatchedagePolymerasechainreaction-restrictionfragmentlengthPCR-RFLPtechniqueusedgenotypesRESULTS:dataindicatedSNP455119-1892325073-1637CCAA328145-0739412203-0835698564-0864AdditionallyGGPRanalysisobservedAAG689539-0881GAG511125-2031GCGalsosignificantsizeCONCLUSION:resultssuggestmaycontributeprognosis

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