Agonistic encounters and cellular angst: social interactions induce heat shock proteins in juvenile salmonid fish.

Suzanne Currie, Sacha LeBlanc, M Alexandrea Watters, Kathleen M Gilmour
Author Information
  1. Suzanne Currie: Department of Biology, Mount Allison University, Sackville, New Brunswick, Canada. scurrie@mta.ca

Abstract

Juvenile salmonid fish readily form dominance hierarchies when faced with limited resources. While these social interactions may result in profound behavioural and physiological stress, it is unknown if this social stress is evident at the level of the cellular stress response--specifically, the induction of stress or heat shock proteins (Hsps). Thus, the goal of our study was to determine if Hsps are induced during hierarchy formation in juvenile rainbow trout (Oncorhynchus mykiss). To this end, we measured levels of three Hsps, Hsp70, Hsc (heat shock cognate)70 and Hsp90 in the white muscle, liver and brain of trout that had been interacting for 36 h, 72 h or 6 days. Our data indicate that Hsps are induced in both dominant and subordinate fish in a time- and tissue-specific manner. In further mechanistic experiments on fasted and cortisol-treated fish, we demonstrated that high plasma cortisol does not affect Hsp induction in trout white muscle or liver, but both conditions may be part of the mechanism for Hsp induction with social stress in the brain. We conclude that the behavioural and physiological stress experienced by juvenile rainbow trout in dominance hierarchies can be extended to the induction of Hsps.

References

  1. Psychoneuroendocrinology. 2004 Oct;29(9):1142-52 [PMID: 15219638]
  2. J Exp Biol. 2005 Jul;208(Pt 14):2707-18 [PMID: 16000540]
  3. Am J Physiol Cell Physiol. 2003 Jun;284(6):C1508-15 [PMID: 12584114]
  4. Integr Comp Biol. 2005 Apr;45(2):263-73 [PMID: 21676770]
  5. Physiol Biochem Zool. 2006 Jul-Aug;79(4):675-87 [PMID: 16826494]
  6. J Exp Biol. 2008 Sep;211(Pt 18):3041-56 [PMID: 18775941]
  7. Physiol Biochem Zool. 2005 Sep-Oct;78(5):695-705 [PMID: 16052453]
  8. Eur J Biochem. 2004 Feb;271(4):703-12 [PMID: 14764086]
  9. Annu Rev Cell Dev Biol. 1995;11:441-69 [PMID: 8689565]
  10. Ecotoxicol Environ Saf. 2007 Sep;68(1):13-9 [PMID: 17257677]
  11. Zoolog Sci. 2002 Jul;19(7):735-40 [PMID: 12149573]
  12. Endocr Rev. 2000 Feb;21(1):55-89 [PMID: 10696570]
  13. Physiol Biochem Zool. 2001 May-Jun;74(3):383-9 [PMID: 11331510]
  14. Aquat Toxicol. 2007 May 1;82(2):85-93 [PMID: 17367878]
  15. Proc Biol Sci. 2005 Aug 22;272(1573):1655-62 [PMID: 16087419]
  16. Science. 2003 Oct 10;302(5643):296-9 [PMID: 14551438]
  17. Biol Psychiatry. 2009 Oct 1;66(7):686-90 [PMID: 19500777]
  18. Physiol Rev. 1992 Oct;72(4):1063-81 [PMID: 1438579]
  19. Cell Stress Chaperones. 1999 Sep;4(3):199-204 [PMID: 10547069]
  20. Annu Rev Physiol. 2005;67:225-57 [PMID: 15709958]
  21. Science. 2008 Nov 7;322(5903):896-900 [PMID: 18988841]
  22. Circulation. 2002 Jul 9;106(2):196-201 [PMID: 12105158]
  23. J Exp Biol. 2005 Jul;208(Pt 14):2773-81 [PMID: 16000546]
  24. Proc Biol Sci. 2008 Feb 22;275(1633):393-402 [PMID: 18055387]
  25. Biochem Biophys Res Commun. 2005 Apr 1;329(1):51-7 [PMID: 15721272]
  26. Proc R Soc Lond B Biol Sci. 1989 Feb 22;236(1282):21-7 [PMID: 2565572]
  27. Comp Biochem Physiol Part D Genomics Proteomics. 2006 Jun;1(2):238-52 [PMID: 20483255]
  28. Physiol Biochem Zool. 2008 Jul-Aug;81(4):414-25 [PMID: 18507532]
  29. Cell. 1978 Dec;15(4):1277-86 [PMID: 569556]
  30. Pharmacol Ther. 1998 Aug;79(2):129-68 [PMID: 9749880]
  31. J Exp Biol. 2006 Aug;209(Pt 15):2859-72 [PMID: 16857869]
  32. Comp Biochem Physiol B Biochem Mol Biol. 2005 Dec;142(4):426-31 [PMID: 16257553]
  33. Proc R Soc Lond B Biol Sci. 1989 Feb 22;236(1282):7-19 [PMID: 2565574]
  34. J Hered. 2005 May-Jun;96(3):261-78 [PMID: 15653555]
  35. Trends Biochem Sci. 1999 Apr;24(4):136-41 [PMID: 10322418]
  36. Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R680-7 [PMID: 12185003]
  37. Gen Comp Endocrinol. 2001 Oct;124(1):97-105 [PMID: 11703075]
  38. Genes Dev. 1998 Dec 15;12(24):3788-96 [PMID: 9869631]
  39. Science. 2002 Feb 1;295(5556):865-8 [PMID: 11823645]
  40. Brain Behav Evol. 1999 Nov;54(5):263-75 [PMID: 10640786]
  41. Breast Cancer Res Treat. 2000 Feb;59(3):199-209 [PMID: 10832590]
  42. Eur J Biochem. 1992 Mar 1;204(2):893-900 [PMID: 1371753]
  43. Comp Biochem Physiol A Mol Integr Physiol. 2006 Feb;143(2):162-72 [PMID: 16403476]
  44. J Exp Zool. 1999 Aug 1;284(3):286-98 [PMID: 10404120]
  45. Stress. 1998 Dec;2(4):265-72 [PMID: 9876257]

MeSH Term

Animals
Brain
Heat-Shock Proteins
Hydrocortisone
Liver
Muscle, Skeletal
Oncorhynchus mykiss
Social Dominance
Stress, Physiological
Stress, Psychological

Chemicals

Heat-Shock Proteins
Hydrocortisone

Word Cloud

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