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Trends in endocrinology and metabolism: TEM
Mar, 2010;21 (3): 134-41.

Metabolic reprogramming, caloric restriction and aging.

Rozalyn M Anderson, Richard Weindruch
Author Information
  1. Rozalyn M Anderson: Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, University of Wisconsin-Madison, Madison, WI 53705, USA. rmanderson5@wisc.edu
PMID: 20004110 DOI: 10.1016/j.tem.2009.11.005

Abstract

Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms. The inverse linear relationship between calorie intake and lifespan suggests that regulators of energy metabolism are important in the actions of CR. Studies in several species reveal tissue-specific changes in energy metabolism with CR and suggest that metabolic reprogramming plays a critical role in its mechanism of aging retardation. We herein describe common signatures of CR and suggest how they can slow aging. We discuss recent advances in understanding the function of key metabolic regulators that probably coordinate the response to altered nutrient availability with CR and how the pathways they regulate can retard the aging process.

References

  1. Cell. 2007 Apr 6;129(1):111-22 [PMID: 17418790]
  2. Circulation. 2008 Jan 15;117(2):216-23 [PMID: 18158361]
  3. Curr Genomics. 2007 Nov;8(7):423-8 [PMID: 19412415]
  4. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2348-55 [PMID: 18931029]
  5. Aging Cell. 2007 Dec;6(6):827-39 [PMID: 18001293]
  6. PLoS Med. 2007 Mar;4(3):e76 [PMID: 17341128]
  7. Physiol Genomics. 2009 Mar 3;37(1):58-66 [PMID: 19106183]
  8. Science. 2009 Jul 10;325(5937):201-4 [PMID: 19590001]
  9. Am J Physiol Cell Physiol. 2009 Jan;296(1):C116-23 [PMID: 19005163]
  10. Nature. 2006 Dec 14;444(7121):860-7 [PMID: 17167474]
  11. Science. 2006 Jun 16;312(5780):1650-3 [PMID: 16728594]
  12. Circulation. 2007 Dec 11;116(24):2809-17 [PMID: 18040027]
  13. Dev Cell. 2008 May;14(5):661-73 [PMID: 18477450]
  14. Cell. 2009 Oct 2;139(1):149-60 [PMID: 19804760]
  15. Cell Metab. 2006 Jul;4(1):75-87 [PMID: 16814734]
  16. Cell Mol Life Sci. 2007 Jun;64(11):1323-8 [PMID: 17396225]
  17. PLoS Genet. 2007 Nov;3(11):e201 [PMID: 18081424]
  18. Cell Metab. 2007 Apr;5(4):265-77 [PMID: 17403371]
  19. J Biol Chem. 2006 Sep 15;281(37):27643-52 [PMID: 16847060]
  20. J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):21-33 [PMID: 19196905]
  21. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2188-93 [PMID: 19179292]
  22. PLoS Genet. 2009 May;5(5):e1000486 [PMID: 19461873]
  23. Exp Gerontol. 2004 Jul;39(7):1049-59 [PMID: 15236764]
  24. Nature. 2008 Aug 14;454(7206):846-51 [PMID: 18668043]
  25. Cell Metab. 2008 Aug;8(2):99-104 [PMID: 18680711]
  26. Nature. 2009 Jul 16;460(7253):392-5 [PMID: 19587680]
  27. Mol Cell. 2008 Apr 25;30(2):214-26 [PMID: 18439900]
  28. Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):313-25 [PMID: 17507280]
  29. J Biol Chem. 2009 Jan 16;284(3):1718-24 [PMID: 18990685]
  30. FASEB J. 2008 Mar;22(3):807-18 [PMID: 17928362]
  31. Science. 2004 Jul 16;305(5682):390-2 [PMID: 15205477]
  32. Cell Metab. 2008 Nov;8(5):399-410 [PMID: 19046571]
  33. Science. 2007 Jul 20;317(5836):369-72 [PMID: 17641201]
  34. Biochem J. 2008 Feb 1;409(3):623-33 [PMID: 18177270]
  35. J Biol Chem. 2006 Jun 16;281(24):16391-400 [PMID: 16621799]
  36. Nature. 2009 Apr 23;458(7241):1056-60 [PMID: 19262508]
  37. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8 [PMID: 18599449]
  38. Annu Rev Biochem. 2008;77:727-54 [PMID: 18373439]
  39. J Nutr. 2006 Feb;136(2):343-52 [PMID: 16424110]
  40. BMC Genomics. 2007 Mar 23;8:80 [PMID: 17381838]
  41. PLoS One. 2008 Mar 12;3(3):e1759 [PMID: 18335035]
  42. Mol Cell Biol. 2007 Jul;27(13):4698-707 [PMID: 17452443]
  43. Exp Gerontol. 2007 Aug;42(8):733-44 [PMID: 17624709]
  44. Biochim Biophys Acta. 2009 Oct;1790(10):1059-66 [PMID: 19371772]
  45. FASEB J. 2004 Feb;18(2):415-7 [PMID: 14688200]
  46. Bioinformatics. 2009 Apr 1;25(7):875-81 [PMID: 19189975]
  47. Exp Gerontol. 2008 Dec;43(12):1069-76 [PMID: 18852040]
  48. Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1618-27 [PMID: 18321952]
  49. Aging Cell. 2008 Oct;7(5):681-7 [PMID: 18843793]
  50. Cancer Res. 2006 Dec 1;66(23):11462-70 [PMID: 17145894]
  51. Ageing Res Rev. 2005 Jan;4(1):55-65 [PMID: 15619470]
  52. Aging Cell. 2007 Dec;6(6):759-67 [PMID: 17877786]
  53. Diabetes. 2009 Apr;58(4):965-74 [PMID: 19136651]
  54. Cell Metab. 2007 Feb;5(2):151-6 [PMID: 17276357]
  55. J Physiol. 2003 Aug 15;551(Pt 1):169-78 [PMID: 12813156]
  56. Nature. 2007 Nov 29;450(7170):736-40 [PMID: 18046414]
  57. PLoS Biol. 2007 Oct 2;5(10):e261 [PMID: 17914901]
  58. Aging Cell. 2008 Jan;7(1):101-11 [PMID: 18031569]
  59. Aging Cell. 2007 Oct;6(5):673-88 [PMID: 17874999]
  60. Cell Metab. 2008 Oct;8(4):333-41 [PMID: 18840364]
  61. Genes Dev. 2008 Jul 1;22(13):1753-7 [PMID: 18550784]
  62. Science. 2009 Jun 5;324(5932):1289-93 [PMID: 19498162]
  63. Cancer Res. 2008 Jul 1;68(13):5492-9 [PMID: 18593953]
  64. Interdiscip Top Gerontol. 2007;35:18-38 [PMID: 17063031]
  65. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22 [PMID: 17609368]
  66. Am J Clin Nutr. 2006 Nov;84(5):1033-42 [PMID: 17093155]
  67. J Clin Invest. 2009 Mar;119(3):573-81 [PMID: 19188683]
  68. Science. 2005 Oct 14;310(5746):314-7 [PMID: 16224023]
  69. Cell Metab. 2008 Nov;8(5):347-58 [PMID: 19046567]
  70. FASEB J. 2006 Sep;20(11):1889-91 [PMID: 16891621]
  71. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E210-8 [PMID: 17389708]

Grants

  1. UL1 RR025011-01/NCRR NIH HHS
  2. AG11915/NIA NIH HHS
  3. P20 CA103697-05/NCI NIH HHS
  4. UL1 RR025011/NCRR NIH HHS
  5. P20 CA103697/NCI NIH HHS
  6. UL1RR025011/NCRR NIH HHS
  7. CA103697/NCI NIH HHS
  8. P01 AG011915-14/NIA NIH HHS
  9. P01 AG011915/NIA NIH HHS

MeSH Term

Aging
Animals
Caloric Restriction
Energy Metabolism
Humans
Models, Biological
Signal Transduction
Journal Article Research Support, N.I.H., Extramural Review
Article has an altmetric score of 15

Word Cloud

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