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Future microbiology
Jan, 2010;5 (1): 23-41.

Innate immune evasion strategies of influenza viruses.

Benjamin G Hale, Randy A Albrecht, Adolfo García-Sastre
Author Information
  1. Benjamin G Hale: Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA. ben.hale@mssm.edu
PMID: 20020828 DOI: 10.2217/fmb.09.108

Abstract

Influenza viruses are globally important human respiratory pathogens. These viruses cause seasonal epidemics and occasional worldwide pandemics, both of which can vary significantly in disease severity. The virulence of a particular influenza virus strain is partly determined by its success in circumventing the host immune response. This article briefly reviews the innate mechanisms that host cells have evolved to resist virus infection, and outlines the plethora of strategies that influenza viruses have developed in order to counteract such powerful defences. The molecular details of this virus-host interplay are summarized, and the ways in which research in this area is being applied to the rational design of protective vaccines and novel antivirals are discussed.

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Grants

  1. R01 AI46954/NIAID NIH HHS
  2. R01 AI046954-09/NIAID NIH HHS
  3. U19 AI062623-01/NIAID NIH HHS
  4. U19 AI62623/NIAID NIH HHS
  5. U54 AI057158/NIAID NIH HHS
  6. U19 AI062623/NIAID NIH HHS
  7. HHSN266200700010C/NIAID NIH HHS
  8. R01 AI046954/NIAID NIH HHS
  9. U54 AI057158-06/NIAID NIH HHS

MeSH Term

Antiviral Agents
Humans
Immune Evasion
Immunity, Innate
Influenza Vaccines
Influenza, Human
Orthomyxoviridae

Chemicals

Antiviral Agents
Influenza Vaccines
Journal Article Research Support, N.I.H., Extramural Review
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