OpenLB
Open Library of Bioscience
Advanced Search
Nature neuroscience
Apr, 2010;13 (4): 482-8.

Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC.

Daejong Jeon, Sangwoo Kim, Mattu Chetana, Daewoong Jo, H Earl Ruley, Shih-Yao Lin, Dania Rabah, Jean-Pierre Kinet, Hee-Sup Shin
Author Information
  1. Daejong Jeon: Center for Neural Science, Korea Institute of Science and Technology, Seoul, Korea.
PMID: 20190743 DOI: 10.1038/nn.2504

Abstract

Fear can be acquired vicariously through social observation of others suffering from aversive stimuli. We found that mice (observers) developed freezing behavior by observing other mice (demonstrators) receive repetitive foot shocks. Observers had higher fear responses when demonstrators were socially related to themselves, such as siblings or mating partners. Inactivation of anterior cingulate cortex (ACC) and parafascicular or mediodorsal thalamic nuclei, which comprise the medial pain system representing pain affection, substantially impaired this observational fear learning, whereas inactivation of sensory thalamic nuclei had no effect. The ACC neuronal activities were increased and synchronized with those of the lateral amygdala at theta rhythm frequency during this learning. Furthermore, an ACC-limited deletion of Ca(v)1.2 Ca(2+) channels in mice impaired observational fear learning and reduced behavioral pain responses. These results demonstrate the functional involvement of the affective pain system and Ca(v)1.2 channels of the ACC in observational social fear.

References

  1. Prog Neurobiol. 1999 Jan;57(1):1-164 [PMID: 9987804]
  2. J Neurosci. 2001 Jun 1;21(11):4116-24 [PMID: 11356900]
  3. J Exp Psychol Gen. 1993 Mar;122(1):23-38 [PMID: 8440976]
  4. Neuron. 2005 Oct 20;48(2):175-87 [PMID: 16242399]
  5. PLoS One. 2009;4(2):e4387 [PMID: 19209221]
  6. Nat Rev Neurosci. 2003 Mar;4(3):165-78 [PMID: 12612630]
  7. Learn Mem. 2007 Apr 10;14(4):313-7 [PMID: 17522020]
  8. Neuroimage. 2005 Feb 1;24(3):771-9 [PMID: 15652312]
  9. Science. 2000 Jun 9;288(5472):1769-72 [PMID: 10846154]
  10. Nat Rev Neurosci. 2001 Apr;2(4):229-39 [PMID: 11283746]
  11. Exp Neurol. 2004 Jul;188(1):139-48 [PMID: 15191810]
  12. J Comp Physiol Psychol. 1962 Feb;55:123-5 [PMID: 14491896]
  13. Science. 2003 Aug 8;301(5634):846-50 [PMID: 12907806]
  14. Soc Cogn Affect Neurosci. 2007 Mar;2(1):3-11 [PMID: 18985115]
  15. Nat Neurosci. 2007 Sep;10(9):1095-102 [PMID: 17726475]
  16. Neuron. 1999 Sep;24(1):49-65, 111-25 [PMID: 10677026]
  17. Nat Neurosci. 2004 Apr;7(4):398-403 [PMID: 15004562]
  18. Biol Psychiatry. 2008 May 1;63(9):821-31 [PMID: 18155183]
  19. J Neurosci. 1998 Jan 1;18(1):411-8 [PMID: 9412517]
  20. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7092-6 [PMID: 9618544]
  21. Curr Opin Neurobiol. 2008 Aug;18(4):464-8 [PMID: 18835354]
  22. Science. 2004 Feb 20;303(5661):1157-62 [PMID: 14976305]
  23. Biol Psychiatry. 2003 Sep 1;54(5):515-28 [PMID: 12946880]
  24. Nat Rev Neurosci. 2005 Jul;6(7):533-44 [PMID: 15995724]
  25. Behav Brain Sci. 2002 Feb;25(1):1-20; discussion 20-71 [PMID: 12625087]
  26. Psychol Sci. 2004 Dec;15(12):822-8 [PMID: 15563327]
  27. Pain. 2004 Jul;110(1-2):343-53 [PMID: 15275785]
  28. Nebr Symp Motiv. 1977;25:169-217 [PMID: 753989]
  29. Philos Trans R Soc Lond B Biol Sci. 2008 Jun 12;363(1499):2033-9 [PMID: 18292063]
  30. Nature. 2005 Jan 6;433(7021):68-72 [PMID: 15635411]
  31. J Clin Psychol. 1959 Apr;15(2):155-8 [PMID: 13631102]
  32. Trends Cogn Sci. 2000 Jun;4(6):215-222 [PMID: 10827444]
  33. J Neurosci. 2006 Aug 30;26(35):8915-22 [PMID: 16943547]
  34. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1959-63 [PMID: 16446423]
  35. Nat Biotechnol. 2001 Oct;19(10):929-33 [PMID: 11581657]
  36. J Neurophysiol. 2006 Mar;95(3):1630-8 [PMID: 16207788]
  37. J Neurophysiol. 2005 Jul;94(1):878-82 [PMID: 15985698]
  38. Brain. 1995 Feb;118 ( Pt 1):279-306 [PMID: 7895011]
  39. J Neurosci. 2005 Oct 26;25(43):9883-92 [PMID: 16251435]
  40. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13087-92 [PMID: 14555761]
  41. Neuroimage. 2007 Aug 15;37(2):642-51 [PMID: 17588777]
  42. J Neurophysiol. 2002 May;87(5):2490-504 [PMID: 11976386]
  43. Science. 2006 Jun 30;312(5782):1967-70 [PMID: 16809545]
  44. J Comp Physiol Psychol. 1959 Apr;52(2):132-4 [PMID: 13654562]
  45. Neuroimage. 2007 May 15;36(1):232-44 [PMID: 17433880]
  46. Annu Rev Neurosci. 2000;23:155-84 [PMID: 10845062]
  47. Neuron. 2007 May 24;54(4):627-38 [PMID: 17521574]
  48. Neurosci Biobehav Rev. 2010 Feb;34(2):214-23 [PMID: 18718486]
  49. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8077-82 [PMID: 11416168]

Grants

  1. R37 GM053950/NIGMS NIH HHS
  2. R37 GM053950-14/NIGMS NIH HHS

MeSH Term

Animals
Calcium Channels, L-Type
Cerebral Cortex
Conditioning, Classical
Fear
Female
Freezing Reaction, Cataleptic
Gyrus Cinguli
Learning
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Pain
Pain Measurement
Protein Subunits
Rats
Rats, Sprague-Dawley
Social Behavior

Chemicals

CACNA1C protein, mouse
Calcium Channels, L-Type
Protein Subunits
Comparative Study Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 30

Word Cloud

Created with Highcharts 10.0.0fearpainACClearningmicesystemobservationalCa2channelssocialdemonstratorsresponsesthalamicnucleiimpairedv1affectiveFearcanacquiredvicariouslyobservationotherssufferingaversivestimulifoundobserversdevelopedfreezingbehaviorobservingreceiverepetitivefootshocksObservershighersociallyrelatedsiblingsmatingpartnersInactivationanteriorcingulatecortexparafascicularmediodorsalcomprisemedialrepresentingaffectionsubstantiallywhereasinactivationsensoryeffectneuronalactivitiesincreasedsynchronizedlateralamygdalathetarhythmfrequencyFurthermoreACC-limiteddeletion2+reducedbehavioralresultsdemonstratefunctionalinvolvementObservationalinvolvesCav1Ca2+

Similar Articles

Cited By