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Current diabetes reports
Jun, 2010;10 (3): 192-8.

The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.

Dima L Diab, David A D'Alessio
Author Information
  1. Dima L Diab: Division of Endocrinology/Metabolism, Cincinnati VA Medical Center, University of Cincinnati, ML 0547, Vontz Center, Cincinnati, OH 45220-0547, USA.
PMID: 20425582 DOI: 10.1007/s11892-010-0114-6

Abstract

The gastrointestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), termed incretins, are essential regulators of normal glucose homeostasis. Research indicates that the incretin effect is impaired in type 2 diabetes, and this seems to be a consequence rather than a cause of type 2 diabetes. This review describes the defects in the incretin system seen in diabetic patients and discusses the potential roles of GIP and GLP-1 in the pathogenesis of type 2 diabetes. In addition, new information on clinical applications that exploit the enteroinsular axis to control blood glucose is discussed.

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MeSH Term

Animals
Diabetes Mellitus, Type 2
Gastrointestinal Hormones
Humans
Hypoglycemic Agents
Incretins
Insulin

Chemicals

Gastrointestinal Hormones
Hypoglycemic Agents
Incretins
Insulin
Journal Article Review

Word Cloud

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