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International journal of molecular sciences
Feb 26, 2010;11 (3): 789-806.

Interleukin 12 a key immunoregulatory cytokine in infection applications.

Therwa Hamza, John B Barnett, Bingyun Li
Author Information
  1. Therwa Hamza: Department of Orthopaedics, West Virginia University, Morgantown, 26506, USA. thamza@hsc.wvu.edu
PMID: 20479986 DOI: 10.3390/ijms11030789

Abstract

Interleukin 12 (termed IL-12p70 and commonly designated IL-12) is an important immunoregulatory cytokine that is produced mainly by antigen-presenting cells. The expression of IL-12 during infection regulates innate responses and determines the type of adaptive immune responses. IL-12 induces interferon-gamma (IFN-gamma) production and triggers CD4(+) T cells to differentiate into type 1 T helper (Th1) cells. Studies have suggested that IL-12 could play a vital role in treating many diseases, such as viral and bacterial infections and cancers. The unique heterodimeric structure, which IL-12 shares with its family members including IL-23, IL-27, and IL-35, has recently brought more attention to understanding the mechanisms that regulate the functions of IL-12. This article describes the structure and biological activities of IL-12 in both the innate and adaptive arms of the immune system, and discusses the applications of IL-12 in treating and preventing infections.

Keywords

cell signaling cell-mediated immunity infection interferon-γ interleukin 12

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MeSH Term

Amino Acid Sequence
Animals
Bacterial Infections
Humans
Interleukin-12
Molecular Sequence Data
Virus Diseases

Chemicals

Interleukin-12
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review
Article has an altmetric score of 16

Word Cloud

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