Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits.

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Armando Geraldes, Teri Rambo, Rod A Wing, Nuno Ferrand, Michael W Nachman

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Armando Geraldes: CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, Campus Agrário de Vairão, Vairão, Portugal. geraldes@interchange.ubc.ca

PMID: 20525900 DOI: 10.1093/molbev/msq139

The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have remained nearly identical. This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome.

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R01 GM074245/NIGMS NIH HHS
R01 GM074245-05/NIGMS NIH HHS

Animals

Base Sequence

Europe

Evolution, Molecular

Gene Conversion

Gene Dosage

Genes, sry

Genetic Variation

Humans

Inverted Repeat Sequences

Nucleotides

Rabbits

Sequence Homology, Nucleic Acid

Nucleotides

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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