Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs.
Christopher J Tegeler, Robert W Grange, Daniel J Bogan, Chad D Markert, Doug Case, Joe N Kornegay, Martin K Childers
Author Information
Christopher J Tegeler: Wake Forest University Health Sciences, Institute for Regenerative Medicine, 391 Technology Way, Winston-Salem, North Carolina 27101, USA.
We tested the hypothesis that eccentric contractions (ECCs) rapidly induce greater-than-normal isometric torque drop in dystrophin-deficient golden retriever muscular dystrophy (GRMD) muscles. ECCs were imposed by forcibly stretching activated muscles. The results indicate that isometric torque drop was greater in GRMD versus controls (P < 0.0001). Our findings support the hypothesis that ECCs induce greater-than-normal isometric torque drop in GRMD muscles. The magnitude of ECC-induced isometric torque loss may be an ideal clinical endpoint in the GRMD model.
