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Current opinion in genetics & development
Oct, 2010;20 (5): 500-4.

Control of embryonic stem cell identity by nucleosome remodeling enzymes.

Thomas G Fazzio, Barbara Panning
Author Information
  1. Thomas G Fazzio: Program in Gene Function and Expression, University of Massachusetts Medical School, United States.
PMID: 20800472 DOI: 10.1016/j.gde.2010.08.001

Abstract

Embryonic stem (ES) cells are pluripotent cells that can self-renew indefinitely or be induced to differentiate into multiple cell lineages, and thus have the potential to be used in regenerative medicine. Pluripotency transcription factors (TFs), such as Oct4, Sox2, and Nanog, function in a regulatory circuit that silences the expression of key TFs required for differentiation and activates the expression of genes important for maintenance of pluripotency. In addition, proteins that remodel chromatin structure also play important roles in determining the ES cell-specific gene expression pattern. Here we review recent studies demonstrating the roles of enzymes that carry out one facet of chromatin regulation, nucleosome remodeling, in control of ES cell self-renewal and differentiation.

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Grants

  1. R00 CA140854/NCI NIH HHS
  2. R01 GM085186/NIGMS NIH HHS
  3. 4R00CA140854-02/NCI NIH HHS
  4. R01GM085186/NIGMS NIH HHS

MeSH Term

Animals
Cell Differentiation
Cell Lineage
Chromatin Assembly and Disassembly
Embryonic Stem Cells
Gene Expression Profiling
Nucleosomes
Pluripotent Stem Cells
Transcription Factors

Chemicals

Nucleosomes
Transcription Factors
Journal Article Research Support, N.I.H., Extramural Review

Word Cloud

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