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Toxicology letters
Nov 30, 2010;199 (2): 136-43.

Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats.

Banafsheh Jolous-Jamshidi, Howard C Cromwell, Ashley M McFarland, Lee A Meserve
Author Information
  1. Banafsheh Jolous-Jamshidi: Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403-0208, USA.
PMID: 20813172 DOI: 10.1016/j.toxlet.2010.08.015

Abstract

Perinatal exposure to polychlorinated biphenyls (PCBs) leads to significant alterations of neural and hormonal systems. These alterations have been shown to impair motor and sensory development. Less is known about the influence of PCB exposure on developing emotional and motivational systems involved in social interactions and social learning. The present study examined the impact of perinatal PCB exposure (mixture of congeners 47 and 77) on social recognition in juvenile animals, conspecific-directed investigation in adults and on neural and hormonal systems involved in social functions. We used a standard habituation-dishabituation paradigm to evaluate juvenile recognition and a social port paradigm to monitor adult social investigation. Areal measures of the periventricular nucleus (PVN) of the hypothalamus were obtained to provide correlations with related hormone and brain systems. PCB exposed rats were significantly impaired in social recognition as indicated by persistent conspecific-directed exploration by juvenile animals regardless of social experience. As adults, PCB exposure led to a dampening of the isolation-induced enhancement of social investigation. There was not a concomitant alteration of social investigation in pair-housed PCB exposed animals at this stage of development. Interestingly, PVN area was significantly decreased in juvenile animals exposed to PCB during the perinatal period. Shifts in hypothalamic regulation of hormones involved in social behavior and stress could be involved in the behavioral changes observed. Overall, the results suggest that PCB exposure impairs context or experience-dependent modulation of social approach and investigation. These types of social-context deficits are similar to behavioral deficits observed in social disorders such as autism and other pervasive developmental disorders.

References

  1. Environ Health Perspect. 2010 Jun;118(6):796-802 [PMID: 20146964]
  2. Bull Environ Contam Toxicol. 1992 May;48(5):715-20 [PMID: 1324039]
  3. Environ Health Perspect. 2009 Sep;117(9):1454-60 [PMID: 19750113]
  4. Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):830-9 [PMID: 16702358]
  5. Nature. 2010 Mar 18;464(7287):413-7 [PMID: 20182426]
  6. Physiol Behav. 2005 Jan 31;84(1):81-6 [PMID: 15642610]
  7. Environ Int. 2007 Apr;33(3):397-405 [PMID: 17270272]
  8. Environ Health Perspect. 2008 Oct;116(10):1416-22 [PMID: 18941588]
  9. Physiol Behav. 2007 Aug 15;91(5):658-66 [PMID: 17498760]
  10. Toxicology. 2004 Oct 15;203(1-3):99-107 [PMID: 15363586]
  11. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):46-54 [PMID: 19464308]
  12. Behav Brain Res. 2009 Jun 25;200(2):323-35 [PMID: 19150375]
  13. Horm Behav. 2007 Mar;51(3):364-72 [PMID: 17274994]
  14. Prog Neurobiol. 2008 Jan;84(1):1-24 [PMID: 18053631]
  15. Physiol Behav. 1986;37(6):869-73 [PMID: 3786481]
  16. Anim Behav. 1999 Sep;58(3):629-634 [PMID: 10479378]
  17. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Oct;27(4):286-300 [PMID: 19953400]
  18. Behav Neurosci. 1999 Jun;113(3):602-11 [PMID: 10443786]
  19. Ann Ist Super Sanita. 2006;42(4):410-6 [PMID: 17361063]
  20. Dev Psychobiol. 2008 May;50(4):322-31 [PMID: 18393285]
  21. ILAR J. 2009;50(1):43-50 [PMID: 19106451]
  22. Eur Neuropsychopharmacol. 1991 Dec;1(4):555-60 [PMID: 1668316]
  23. Toxicol Sci. 2004 Dec;82(2):577-89 [PMID: 15456922]
  24. Environ Health Perspect. 1996 Apr;104 Suppl 2:299-305 [PMID: 9182036]
  25. Toxicol Sci. 2005 Jul;86(1):125-31 [PMID: 15843507]
  26. Dev Psychobiol. 1982 Jan;15(1):1-8 [PMID: 7054012]
  27. Environ Health Perspect. 2005 Jun;113(6):700-7 [PMID: 15929892]
  28. Toxicol Ind Health. 2000 Sep;16(7-8):305-33 [PMID: 11693948]
  29. Arch Environ Contam Toxicol. 1975-1976;3(4):479-90 [PMID: 816261]
  30. Neurotoxicol Teratol. 1988 May-Jun;10(3):193-7 [PMID: 3211096]
  31. Appl Anim Behav Sci. 2000 Apr 3;67(3):241-254 [PMID: 10736532]
  32. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7646-51 [PMID: 17460041]
  33. J Comp Neurol. 2009 Nov 10;517(2):156-65 [PMID: 19731312]
  34. Front Behav Neurosci. 2009 Jun 29;3:10 [PMID: 19587848]
  35. Pharmacol Biochem Behav. 1997 Nov;58(3):643-7 [PMID: 9329053]
  36. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1173-7 [PMID: 19563853]
  37. Tohoku J Exp Med. 2007 Jun;212(2):151-7 [PMID: 17548959]
  38. Eur Neuropsychopharmacol. 1991 May;1(2):123-6 [PMID: 1821701]
  39. Reprod Toxicol. 2008 Aug;25(4):447-54 [PMID: 18502095]
  40. Front Neuroendocrinol. 2009 Oct;30(4):497-518 [PMID: 19341763]
  41. Endocrinology. 2008 Jul;149(7):3256-63 [PMID: 18356275]
  42. Neurotoxicol Teratol. 1987 Jan-Feb;9(1):51-7 [PMID: 3627077]
  43. Brain Pathol. 2007 Oct;17(4):448-59 [PMID: 17919130]
  44. Toxicology. 1999 Oct 29;138(1):11-7 [PMID: 10566587]
  45. Ross Fiziol Zh Im I M Sechenova. 2001 Jun;87(6):730-51 [PMID: 11534200]
  46. Neurotoxicol Teratol. 1997 Sep-Oct;19(5):383-9 [PMID: 9380005]
  47. Contemp Top Lab Anim Sci. 2003 Mar;42(2):29-30 [PMID: 19757622]
  48. Growth Dev Aging. 1996 Autumn-Winter;60(3-4):131-43 [PMID: 9007564]
  49. Biol Reprod. 2008 Jun;78(6):1091-101 [PMID: 18305224]
  50. Physiol Behav. 2001 Oct;74(3):363-70 [PMID: 11714501]
  51. J Neuroendocrinol. 2008 Jun;20(6):858-65 [PMID: 18601710]
  52. Rev Environ Health. 2006 Jan-Mar;21(1):1-23 [PMID: 16700427]
  53. Toxicol Sci. 2002 Jan;65(1):52-61 [PMID: 11752685]
  54. Neurotoxicology. 2010 Jan;31(1):17-25 [PMID: 19854214]
  55. Neuropharmacology. 2007 Mar;52(3):724-32 [PMID: 17097693]
  56. Prog Neuropsychopharmacol Biol Psychiatry. 1999 Jul;23(5):915-28 [PMID: 10509384]
  57. Physiol Behav. 2010 Feb 9;99(2):260-8 [PMID: 19758571]
  58. Physiol Behav. 2008 Oct 20;95(3):471-5 [PMID: 18680757]
  59. J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):351-72 [PMID: 18368561]
  60. Physiol Behav. 2005 Jun 2;85(2):83-91 [PMID: 15878184]
  61. Pol J Vet Sci. 2006;9(2):101-8 [PMID: 16780177]
  62. Toxicol Sci. 2007 Jul;98(1):178-86 [PMID: 17434953]
  63. Neurotoxicol Teratol. 2006 Mar-Apr;28(2):260-77 [PMID: 16487679]
  64. Toxicol Appl Pharmacol. 1995 Nov;135(1):77-88 [PMID: 7482542]
  65. Neurotoxicol Teratol. 1999 Jul-Aug;21(4):435-43 [PMID: 10440487]
  66. Neurotoxicology. 1998 Aug-Oct;19(4-5):517-25 [PMID: 9745906]
  67. Environ Health Perspect. 2002 Oct;110(10):A593-8 [PMID: 12361940]
  68. Environ Health Perspect. 2006 Feb;114(2):194-201 [PMID: 16451854]
  69. Arch Toxicol. 1998 Apr;72(5):314-7 [PMID: 9630019]
  70. Behav Neurosci. 2004 Apr;118(2):298-305 [PMID: 15113254]
  71. Dev Psychobiol. 1999 Mar;34(2):129-38 [PMID: 10086231]
  72. Neurosci Biobehav Rev. 2005;29(4-5):843-65 [PMID: 15893378]
  73. Endocrine. 2001 Mar;14(2):235-46 [PMID: 11394642]
  74. Physiol Behav. 2002 Apr 15;75(5):689-96 [PMID: 12020734]
  75. Rev Environ Health. 2007 Oct-Dec;22(4):313-28 [PMID: 18351230]
  76. Dev Psychobiol. 1992 May;25(4):261-74 [PMID: 1624056]
  77. Rev Environ Contam Toxicol. 2009;201:137-58 [PMID: 19484591]
  78. Neurotoxicology. 2009 May;30(3):331-7 [PMID: 19442816]
  79. Stress. 2009 May;12(3):250-8 [PMID: 18951246]
  80. Physiol Behav. 2009 Aug 4;98(1-2):247-50 [PMID: 19447123]

Grants

  1. R03 HD053692/NICHD NIH HHS

MeSH Term

Animals
Behavior, Animal
Body Weight
Eating
Emotions
Female
Fetus
Humans
Male
Motivation
Paraventricular Hypothalamic Nucleus
Polychlorinated Biphenyls
Rats
Rats, Sprague-Dawley
Social Behavior
Social Isolation

Chemicals

Polychlorinated Biphenyls
Journal Article

Word Cloud

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