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Journal of the American Academy of Child and Adolescent Psychiatry
Oct, 2010;49 (10): 1064-80.

Emotion processing influences working memory circuits in pediatric bipolar disorder and attention-deficit/hyperactivity disorder.

Alessandra M Passarotti, John A Sweeney, Mani N Pavuluri
Author Information
  1. Alessandra M Passarotti: Institute for Juvenile Research and Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60608, USA. apassarotti@psych.uic.edu
PMID: 20855051 DOI: 10.1016/j.jaac.2010.07.009

Abstract

OBJECTIVE: This functional magnetic resonance imaging (fMRI) study examined how working memory circuits are affected by face emotion processing in pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD).
METHODS: A total of 23 patients with PBD, 14 patients with ADHD, and 19 healthy control (HC) subjects (mean age, 13.36 ± 2.55 years) underwent an affective, two-back fMRI task with blocks of happy, angry, and neutral faces.
RESULTS: For angry versus neutral faces PBD patients, relative to ADHD patients, exhibited increased activation in the subgenual anterior cingulate cortex (ACC) and orbitofrontal cortex, and reduced activation in the dorsolateral prefrontal cortex (DLPFC) and premotor cortex. Relative to the HC group, the PBD group showed no increased activation and reduced activation at the junction of DLPFC and ventrolateral prefrontal cortex (VLPFC). Relative to HC, the ADHD patients exhibited greater activation in the DLPFC and reduced activation in the ventral and medial PFC, pregenual ACC, striatum, and temporo-parietal regions. For happy versus neutral faces, relative to the ADHD group, the PBD group exhibited greater activation in the bilateral caudate, and relative to the HC group the ADHD group showed increased activation in the DLPFC, striatal, and parietal regions, and no reduced activation. The ADHD group, compared with the HC group, showed no reduced activation and increased activation in regions that were underactive for the angry face condition.
CONCLUSIONS: Relative to the ADHD group, the PBD group exhibited greater deployment of the emotion-processing circuitry and reduced deployment of working memory circuitry. Commonalities across PBD and ADHD patients, relative to the HC individuals, entailed cortico-subcortical activity that was reduced under negative emotional challenge and increased under positive emotional challenge.

References

  1. Child Adolesc Psychiatr Clin N Am. 2008 Apr;17(2):325-46, viii-ix [PMID: 18295149]
  2. Neuropsychologia. 2008 Sep;46(11):2668-82 [PMID: 18573510]
  3. Am J Psychiatry. 2005 Sep;162(9):1644-51 [PMID: 16135623]
  4. Neuroimage. 2010 Feb 1;49(3):2662-70 [PMID: 19883772]
  5. Eur J Neurosci. 2004 Jun;19(12):3365-70 [PMID: 15217392]
  6. Psychiatr Clin North Am. 2004 Jun;27(2):323-47 [PMID: 15064000]
  7. Acta Neuropsychiatr. 2006 Apr;18(2):88-99 [PMID: 26989797]
  8. Biol Psychiatry. 1999 Jun 15;45(12):1542-52 [PMID: 10376114]
  9. J Consult Clin Psychol. 2000 Apr;68(2):313-321 [PMID: 10780132]
  10. Psychiatry Res. 2009 Dec 30;174(3):195-201 [PMID: 19910166]
  11. Biol Psychiatry. 2007 Jul 15;62(2):158-67 [PMID: 17097071]
  12. Am J Psychiatry. 1999 Jun;156(6):891-6 [PMID: 10360128]
  13. J Neurosci Methods. 2002 Apr 15;115(2):137-43 [PMID: 11992665]
  14. Biol Psychiatry. 2007 Jun 15;61(12):1395-401 [PMID: 17046725]
  15. Nat Rev Neurosci. 2002 Mar;3(3):201-15 [PMID: 11994752]
  16. Bipolar Disord. 2004 Dec;6(6):550-64 [PMID: 15541071]
  17. J Am Acad Child Psychiatry. 1984 Mar;23(2):191-7 [PMID: 6715741]
  18. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12061-8 [PMID: 9751790]
  19. Nat Rev Neurosci. 2002 Aug;3(8):617-28 [PMID: 12154363]
  20. J Am Acad Child Adolesc Psychiatry. 2009 Mar;48(3):299-307 [PMID: 19182689]
  21. Psychiatry Res. 2010 Apr 30;182(1):22-9 [PMID: 20227857]
  22. J Learn Disabil. 2009 Jul-Aug;42(4):372-82 [PMID: 19380495]
  23. J Am Acad Child Adolesc Psychiatry. 2005 Apr;44(4):377-84 [PMID: 15782085]
  24. Neuroimage. 2001 Jul;14(1 Pt 1):48-59 [PMID: 11525336]
  25. Br J Psychiatry. 2005 Sep;187:282-3 [PMID: 16135867]
  26. Neuropsychology. 2002 Jan;16(1):102-10 [PMID: 11853351]
  27. Science. 2000 Jun 2;288(5471):1656-60 [PMID: 10834847]
  28. Nat Rev Neurosci. 2003 Oct;4(10):829-39 [PMID: 14523382]
  29. Brain Res Rev. 2008 Nov;59(1):9-21 [PMID: 18539335]
  30. Br J Psychiatry. 1978 Nov;133:429-35 [PMID: 728692]
  31. Arch Gen Psychiatry. 2004 Aug;61(8):781-92 [PMID: 15289277]
  32. Biol Psychiatry. 2006 Nov 15;60(10):1062-70 [PMID: 16712804]
  33. Expert Rev Neurother. 2009 Apr;9(4):489-503 [PMID: 19344301]
  34. Biol Psychiatry. 2009 Dec 1;66(11):988-9 [PMID: 19900610]
  35. Biol Psychiatry. 2005 Oct 1;58(7):517-24 [PMID: 16239160]
  36. Psychol Bull. 1996 Jul;120(1):3-24 [PMID: 8711015]
  37. Hum Brain Mapp. 2009 Mar;30(3):883-95 [PMID: 18344175]
  38. Cereb Cortex. 2000 Mar;10(3):295-307 [PMID: 10731224]
  39. Eur J Neurosci. 2002 Jul;16(2):291-310 [PMID: 12169111]
  40. Curr Opin Neurobiol. 1994 Apr;4(2):207-11 [PMID: 8038578]
  41. Br J Psychiatry. 2002 Apr;180:293-5 [PMID: 11925348]
  42. Cogn Affect Behav Neurosci. 2003 Jun;3(2):81-96 [PMID: 12943324]
  43. Neuroreport. 2007 Oct 8;18(15):1583-7 [PMID: 17885606]
  44. Comput Biomed Res. 1996 Jun;29(3):162-73 [PMID: 8812068]
  45. Neuropharmacology. 2009 Dec;57(7-8):640-52 [PMID: 19715709]
  46. Neuroimage. 2001 Jun;13(6 Pt 1):1090-101 [PMID: 11352614]
  47. Br J Psychiatry. 2001 Aug;179:138-43 [PMID: 11483475]
  48. Psychiatry Res. 2008 Apr 15;162(3):244-55 [PMID: 18294820]
  49. J Neurosci. 2006 Feb 15;26(7):2072-9 [PMID: 16481440]
  50. Aust N Z J Psychiatry. 2009 Aug;43(8):722-30 [PMID: 19629793]
  51. Biol Psychiatry. 2004 Mar 15;55(6):578-87 [PMID: 15013826]
  52. Psychiatry Res. 2010 Jan 30;181(1):36-43 [PMID: 19926457]
  53. Expert Rev Neurother. 2008 Sep;8(9):1381-7 [PMID: 18759550]
  54. J Am Acad Child Adolesc Psychiatry. 2006 Feb;45(2):192-202 [PMID: 16429090]
  55. Psychol Med. 1999 Nov;29(6):1307-21 [PMID: 10616937]
  56. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8900-5 [PMID: 16735472]
  57. Neuropsychology. 2003 Jan;17(1):50-8 [PMID: 12597073]
  58. J Child Psychol Psychiatry. 1997 Sep;38(6):633-44 [PMID: 9315973]
  59. Psychol Bull. 1997 Jan;121(1):65-94 [PMID: 9000892]
  60. Hum Brain Mapp. 2005 May;25(1):46-59 [PMID: 15846822]
  61. Am J Psychiatry. 2000 Feb;157(2):278-80 [PMID: 10671402]
  62. Neuropsychol Rev. 2010 Mar;20(1):103-20 [PMID: 20165924]
  63. Bipolar Disord. 2005;7 Suppl 5:58-69 [PMID: 16225562]
  64. Br J Psychiatry. 2005 Jan;186:32-40 [PMID: 15630121]
  65. Am J Psychiatry. 2010 Jan;167(1):61-9 [PMID: 19917597]
  66. J Am Acad Child Adolesc Psychiatry. 2009 Mar;48(3):308-319 [PMID: 19242292]
  67. J Affect Disord. 1998 Nov;51(2):93-100 [PMID: 10743842]
  68. Neuroimage. 2002 Mar;15(3):523-36 [PMID: 11848695]
  69. Hum Brain Mapp. 2010 Feb;31(2):287-99 [PMID: 19777552]
  70. Cereb Cortex. 2007 Aug;17(8):1788-99 [PMID: 17023555]
  71. Biol Psychiatry. 2008 Sep 15;64(6):513-20 [PMID: 18571627]
  72. Biol Psychiatry. 2000 Oct 1;48(7):674-84 [PMID: 11032979]
  73. J Int Neuropsychol Soc. 2010 Jan;16(1):106-17 [PMID: 19849880]
  74. Br J Psychol. 1970 Aug;61(3):303-21 [PMID: 5457503]
  75. J Cogn Neurosci. 1997 Jul;9(4):462-75 [PMID: 23968211]
  76. Am J Psychiatry. 2006 Feb;163(2):286-93 [PMID: 16449483]
  77. Hum Brain Mapp. 2010 Jan;31(1):115-25 [PMID: 19603410]

Grants

  1. K23 RR018638/NCRR NIH HHS
  2. K23 RR18638-01/NCRR NIH HHS

MeSH Term

Adolescent
Attention Deficit Disorder with Hyperactivity
Bipolar Disorder
Brain
Brain Mapping
Caudate Nucleus
Child
Corpus Striatum
Dominance, Cerebral
Emotions
Facial Expression
Female
Frontal Lobe
Gyrus Cinguli
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
Nerve Net
Parietal Lobe
Prefrontal Cortex
Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0activationgroupADHDPBDreducedpatientsHCincreasedcortexdisorderrelativeexhibitedDLPFCworkingmemoryangryneutralfacesRelativeshowedgreaterregionsfMRIcircuitsfaceprocessingpediatricbipolarattention-deficit/hyperactivityhappyversusACCprefrontaldeploymentcircuitryemotionalchallengeOBJECTIVE:functionalmagneticresonanceimagingstudyexaminedaffectedemotionMETHODS:total231419healthycontrolsubjectsmeanage1336±255yearsunderwentaffectivetwo-backtaskblocksRESULTS:subgenualanteriorcingulateorbitofrontaldorsolateralpremotorjunctionventrolateralVLPFCventralmedialPFCpregenualstriatumtemporo-parietalbilateralcaudatestriatalparietalcomparedunderactiveconditionCONCLUSIONS:emotion-processingCommonalitiesacrossindividualsentailedcortico-subcorticalactivitynegativepositiveEmotioninfluences

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