OpenLB
Open Library of Bioscience
Advanced Search
European journal of pediatrics
Apr, 2011;170 (4): 433-44.

Aerosol delivery to ventilated newborn infants: historical challenges and new directions.

Jan Mazela, Richard A Polin
Author Information
  1. Jan Mazela: Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland. janco@pol-med.com.pl
PMID: 20878336 DOI: 10.1007/s00431-010-1292-6

Abstract

There are several aerosolized drugs which have been used in the treatment of neonatal respiratory illnesses, such as bronchodilators, diuretics, and surfactants. Preclinical in vitro and in vivo studies identified a number of variables that affect aerosol efficiency, including particle size, aerosol flows, nebulizer choice, and placement. Nevertheless, an optimized aerosol drug delivery system for mechanically ventilated infants still does not exist. Increasing interest in this form of drug delivery requires more controlled and focused research of drug/device combinations appropriate for the neonatal population. In the present article, we review the research that has been conducted thus far and discuss the next steps in developing the optimal aerosol delivery system for use in mechanically ventilated neonates.

References

  1. Curr Opin Pediatr. 2007 Apr;19(2):155-62 [PMID: 17496758]
  2. Pediatrics. 2009 Jun;123(6):1524-8 [PMID: 19482763]
  3. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD001694 [PMID: 16855973]
  4. Pediatr Pulmonol. 2000 Feb;29(2):120-6 [PMID: 10639202]
  5. Thorax. 1996 Oct;51(10):985-8 [PMID: 8977597]
  6. Respir Care. 2000 Jun;45(6):636-45 [PMID: 10894456]
  7. Crit Care Med. 1993 Jan;21(1):125-30 [PMID: 8420719]
  8. Arch Dis Child. 2003 Aug;88(8):719-23 [PMID: 12876173]
  9. Acta Paediatr. 1994 Sep;83(9):903-9 [PMID: 7819683]
  10. Chest. 1996 Jun;109(6):1607-13 [PMID: 8769518]
  11. J Pediatr. 2002 Dec;141(6):830-2 [PMID: 12461501]
  12. Pediatrics. 1965 May;35:733-42 [PMID: 14280662]
  13. Respir Care Clin N Am. 2001 Jun;7(2):233-60, vi [PMID: 11517022]
  14. Pediatr Res. 2005 Jul;58(1):10-4 [PMID: 15774850]
  15. Respir Care. 2002 Jan;47(1):31-8 [PMID: 11749685]
  16. J Aerosol Med. 2000 Winter;13(4):303-14 [PMID: 11262437]
  17. Pediatr Pulmonol. 1996 May;21(5):301-9 [PMID: 8726155]
  18. Arch Dis Child. 1992 Jan;67(1 Spec No):25-30 [PMID: 1536581]
  19. Semin Neonatol. 2002 Oct;7(5):369-77 [PMID: 12464499]
  20. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD001969 [PMID: 17943764]
  21. Am J Respir Crit Care Med. 2003 Nov 15;168(10):1205-9 [PMID: 12893644]
  22. Pediatr Res. 2008 Aug;64(2):141-6 [PMID: 18391845]
  23. Arch Dis Child. 1992 Jul;67(7 Spec No):826-30 [PMID: 1325758]
  24. Eur Respir J. 1991 Jun;4(6):694-702 [PMID: 1889496]
  25. Crit Care Med. 2000 Jul;28(7):2540-4 [PMID: 10921591]
  26. Pediatrics. 2007 Aug;120(2):322-9 [PMID: 17671058]
  27. Respir Care. 2010 Jul;55(7):845-51 [PMID: 20587095]
  28. Eur J Respir Dis Suppl. 1982;119:97-100 [PMID: 7047190]
  29. J Card Surg. 2005 Sep-Oct;20(5):436-9 [PMID: 16153274]
  30. Acta Paediatr. 2000 Dec;89(12):1449-55 [PMID: 11195235]
  31. Respir Care. 2000 Jun;45(6):597-608 [PMID: 10894453]
  32. Intensive Care Med. 2003 Jul;29(7):1145-50 [PMID: 12750882]
  33. Arch Dis Child Fetal Neonatal Ed. 2008 Jul;93(4):F275-9 [PMID: 18192330]
  34. Pediatr Pulmonol. 1991;10(2):136-41 [PMID: 1903198]
  35. Acta Paediatr. 2000 Apr;89(4):460-4 [PMID: 10830460]
  36. Can Med Assoc J. 1964 Jan 11;90:55-7 [PMID: 14104151]
  37. Respir Care. 2000 Jun;45(6):646-51 [PMID: 10894457]
  38. Arch Dis Child. 2003 Aug;88(8):659-61 [PMID: 12876155]
  39. Pediatr Pulmonol. 1997 Sep;24(3):222-4 [PMID: 9330420]
  40. Am Rev Respir Dis. 1992 Aug;146(2):383-8 [PMID: 1489128]
  41. J Aerosol Med Pulm Drug Deliv. 2008 Mar;21(1):45-60 [PMID: 18518831]
  42. Pediatr Pulmonol. 1986 Jan-Feb;2(1):19-26 [PMID: 3951890]
  43. Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):382-7 [PMID: 8756810]
  44. Respir Care. 2001 Jan;46(1):43-8 [PMID: 11175237]
  45. Nat Med. 1999 Dec;5(12):1433-6 [PMID: 10581089]
  46. Respir Care. 2008 Jun;53(6):699-723; discussion 723-5 [PMID: 18501026]
  47. J Aerosol Med Pulm Drug Deliv. 2008 Dec;21(4):361-70 [PMID: 18800882]
  48. Int J Pharm. 2008 Jun 24;358(1-2):75-81 [PMID: 18359587]
  49. Pediatr Res. 2004 Oct;56(4):579-85 [PMID: 15295081]
  50. Arch Dis Child. 1990 Apr;65(4):401-3 [PMID: 2111979]
  51. J Aerosol Med Pulm Drug Deliv. 2010 Oct;23(5):303-9 [PMID: 20455772]
  52. N Engl J Med. 2008 Feb 14;358(7):700-8 [PMID: 18272893]
  53. Crit Care Med. 2002 Feb;30(2):355-61 [PMID: 11889309]
  54. Cochrane Database Syst Rev. 2012 Jun 13;(6):CD003214 [PMID: 22696334]
  55. Chest. 1992 Sep;102(3):924-30 [PMID: 1516423]
  56. Am J Respir Crit Care Med. 1994 Jan;149(1):214-9 [PMID: 8111585]
  57. Arch Dis Child Fetal Neonatal Ed. 1994 Nov;71(3):F214-6 [PMID: 7820721]
  58. Anesthesiology. 1989 Jun;70(6):1008-10 [PMID: 2729618]

MeSH Term

Administration, Inhalation
Aerosols
Drug Delivery Systems
Drug Dosage Calculations
Humans
Infant, Newborn
Intensive Care Units, Neonatal
Nebulizers and Vaporizers
Particle Size
Respiration, Artificial

Chemicals

Aerosols
Journal Article Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0aerosoldeliveryventilatedneonataldrugsystemmechanicallyresearchseveralaerosolizeddrugsusedtreatmentrespiratoryillnessesbronchodilatorsdiureticssurfactantsPreclinicalvitrovivostudiesidentifiednumbervariablesaffectefficiencyincludingparticlesizeflowsnebulizerchoiceplacementNeverthelessoptimizedinfantsstillexistIncreasinginterestformrequirescontrolledfocuseddrug/devicecombinationsappropriatepopulationpresentarticlereviewconductedthusfardiscussnextstepsdevelopingoptimaluseneonatesAerosolnewborninfants:historicalchallengesnewdirections

Similar Articles

Cited By