Somatic cell nuclear transfer efficiency: how can it be improved through nuclear remodeling and reprogramming?

Kristin M Whitworth, Randall S Prather
Author Information
  1. Kristin M Whitworth: Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA.

Abstract

Fertile offspring from somatic cell nuclear transfer (SCNT) is the goal of most cloning laboratories. For this process to be successful, a number of events must occur correctly. First the donor nucleus must be in a state that is amenable to remodeling and subsequent genomic reprogramming. The nucleus must be introduced into an oocyte cytoplasm that is capable of facilitating the nuclear remodeling. The oocyte must then be adequately stimulated to initiate development. Finally the resulting embryo must be cultured in an environment that is compatible with the development of that particular embryo. Much has been learned about the incredible changes that occur to a nucleus after it is placed in the cytoplasm of an oocyte. While we think that we are gaining an understanding of the reorganization that occurs to proteins in the donor nucleus, the process of cloning is still very inefficient. Below we will introduce the procedures for SCNT, discuss nuclear remodeling and reprogramming, and review techniques that may improve reprogramming. Finally we will briefly touch on other aspects of SCNT that may improve the development of cloned embryos.

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Grants

  1. P01 HL051670/NHLBI NIH HHS
  2. R01 RR013438/NCRR NIH HHS
  3. R21 NS059519/NINDS NIH HHS
  4. U42 RR018877-07S2/NCRR NIH HHS
  5. U42 RR018877/NCRR NIH HHS

MeSH Term

Animals
Cell Nucleus
Cell Physiological Phenomena
Humans
Mice
Nuclear Transfer Techniques

Word Cloud

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