Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases.

Mary Allen Staat, Laura Patricia Stadler, Stephanie Donauer, Indi Trehan, Marilyn Rice, Shelia Salisbury
Author Information
  1. Mary Allen Staat: Department of Pediatrics, International Adoption Center, Cincinnati Children’s Hospital Medical Center, 3333 BurnetAvenue, ML 7036, Cincinnati, OH 45229-3039, United States. mary.staat@cchmc.org

Abstract

Definitive immunization guidelines for internationally adopted children are lacking. We examined whether these children had serologic evidence of protection against vaccine-preventable diseases. For children with ≥3 vaccine doses, overall protection was high for diphtheria (85%), tetanus (95%), polio (93%), hepatitis B (77%), and Hib (67%). For children ≥12 months of age with ≥1 dose of measles, mumps, or rubella vaccines, 95%, 72%, and 94% were immune, respectively. Children without immunization documentation had lower immunity. Serologic testing was useful in verifying the immunization status in internationally adopted children with and without documentation of immunizations.

References

  1. Vaccine. 2006 May 8;24(19):4138-43 [PMID: 16545505]
  2. Pediatrics. 1999 May;103(5 Pt 1):1078 [PMID: 10357648]
  3. Diagn Immunol. 1986;4(1):17-23 [PMID: 3514070]
  4. Clin Microbiol Rev. 2005 Jul;18(3):510-20 [PMID: 16020687]
  5. Clin Infect Dis. 2009 Sep 15;49(6):817-40 [PMID: 19659433]
  6. Lancet. 2001 Dec 22-29;358(9299):2131-2 [PMID: 11784632]
  7. Pediatrics. 2001 Oct;108(4):1050-1 [PMID: 11589214]
  8. Pediatr Infect Dis J. 2001 Jan;20(1):63-75 [PMID: 11176570]
  9. Pediatrics. 2001 Sep;108(3):608-12 [PMID: 11533325]
  10. Pediatr Infect Dis J. 2001 Nov;20(11 Suppl):S57-62 [PMID: 11704725]
  11. Clin Diagn Lab Immunol. 1996 Jan;3(1):84-8 [PMID: 8770509]
  12. Eur J Pediatr. 2009 Sep;168(9):1101-6 [PMID: 19125292]
  13. J Med Virol. 2001 Dec;65(4):751-7 [PMID: 11745941]
  14. Arch Pediatr Adolesc Med. 2009 May;163(5):473-9 [PMID: 19414695]
  15. MMWR Morb Mortal Wkly Rep. 2009 Jan 30;58(3):58-60 [PMID: 19177041]
  16. MMWR Recomm Rep. 2002 Feb 8;51(RR-2):1-35 [PMID: 11848294]
  17. Vaccine. 2008 Oct 29;26(46):5784-90 [PMID: 18786590]
  18. Matern Child Health J. 2008 Sep;12(5):599-605 [PMID: 17712613]
  19. Clin Infect Dis. 2001 Dec 15;33 Suppl 4:S278-87 [PMID: 11709760]

Grants

  1. 5-T32-ES010957-08/NIEHS NIH HHS
  2. T32 HD049338/NICHD NIH HHS
  3. T32 HD049338-05/NICHD NIH HHS
  4. T32 ES010957/NIEHS NIH HHS
  5. L40 HD066655-01/NICHD NIH HHS
  6. 5-T32-HD049338-03/NICHD NIH HHS

MeSH Term

Adolescent
Adoption
Antibodies, Viral
Child
Child, Preschool
Diphtheria
Emigrants and Immigrants
Haemophilus Infections
Hepatitis B
Humans
Infant
Measles-Mumps-Rubella Vaccine
Poliomyelitis
Serologic Tests
Tetanus
Vaccination

Chemicals

Antibodies, Viral
Measles-Mumps-Rubella Vaccine

Word Cloud

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