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Journal of Zhejiang University. Science. B
Jan, 2011;12 (1): 1-11.

Whole genome amplification in preimplantation genetic diagnosis.

Ying-ming Zheng, Ning Wang, Lei Li, Fan Jin
Author Information
  1. Ying-ming Zheng: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
PMID: 21194180 DOI: 10.1631/jzus.B1000196

Abstract

Preimplantation genetic diagnosis (PGD) refers to a procedure for genetically analyzing embryos prior to implantation, improving the chance of conception for patients at high risk of transmitting specific inherited disorders. This method has been widely used for a large number of genetic disorders since the first successful application in the early 1990s. Polymerase chain reaction (PCR) and fluorescent in situ hybridization (FISH) are the two main methods in PGD, but there are some inevitable shortcomings limiting the scope of genetic diagnosis. Fortunately, different whole genome amplification (WGA) techniques have been developed to overcome these problems. Sufficient DNA can be amplified and multiple tasks which need abundant DNA can be performed. Moreover, WGA products can be analyzed as a template for multi-loci and multi-gene during the subsequent DNA analysis. In this review, we will focus on the currently available WGA techniques and their applications, as well as the new technical trends from WGA products.

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MeSH Term

Alleles
Comparative Genomic Hybridization
DNA Mutational Analysis
DNA Primers
Diagnostic Errors
Female
Haplotypes
Humans
Male
Microsatellite Repeats
Nucleic Acid Amplification Techniques
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Pregnancy
Preimplantation Diagnosis

Chemicals

DNA Primers
Journal Article Research Support, Non-U.S. Gov't Review

Word Cloud

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