OpenLB
Open Library of Bioscience
Advanced Search
Antimicrobial agents and chemotherapy
Apr, 2011;55 (4): 1787-91.

Time-kill activity of the streptogramin NXL 103 against Gram-positive and -negative bacteria.

Glenn A Pankuch, Gengrong Lin, Catherine Clark, Peter C Appelbaum
Author Information
  1. Glenn A Pankuch: Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
PMID: 21245439 DOI: 10.1128/AAC.01159-10

Abstract

Against 33 Gram-positive and -negative bacteria, NXL 103 MICs were 0.03 to 1 μg/ml. NXL 103 was bactericidal by 12 h at 2 × MIC against all 5 pneumococci and at 2 × MIC after 24 h against all 5 group A and B β-hemolytic streptococci. NXL 103 was bactericidal against all 8 Haemophilus influenzae strains at 2 × MIC and all 5 Moraxella catarrhalis strains at 4 × MIC after 24 h but was mainly bacteriostatic against 5 methicillin-resistant Staphylococcus aureus strains. After the exposure of one strain of each species to NXL 103 for 10 daily subcultures, the MICs remained within ± 1 dilution.

References

  1. Antimicrob Agents Chemother. 2007 Sep;51(9):3445-8 [PMID: 17620372]
  2. J Antimicrob Chemother. 2003 Aug;52(2):229-46 [PMID: 12865398]
  3. Antimicrob Agents Chemother. 2010 Jan;54(1):230-8 [PMID: 19884376]
  4. Antimicrob Agents Chemother. 2003 Mar;47(3):1112-4 [PMID: 12604549]
  5. N Engl J Med. 2005 Feb 3;352(5):468-75 [PMID: 15689585]
  6. JAMA. 2003 Dec 10;290(22):2976-84 [PMID: 14665659]
  7. JAMA. 2007 Oct 17;298(15):1772-8 [PMID: 17940232]
  8. Antimicrob Agents Chemother. 2006 Jan;50(1):243-9 [PMID: 16377693]
  9. Clin Microbiol Rev. 2007 Apr;20(2):368-89 [PMID: 17428889]
  10. Antimicrob Agents Chemother. 2000 Feb;44(2):272-7 [PMID: 10639349]
  11. Antimicrob Agents Chemother. 2005 Aug;49(8):3325-33 [PMID: 16048943]
  12. Emerg Infect Dis. 2009 Apr;15(4):547-51 [PMID: 19331730]
  13. Antimicrob Agents Chemother. 2006 Jan;50(1):237-42 [PMID: 16377692]
  14. Int J Antimicrob Agents. 2007 Nov;30(5):398-408 [PMID: 17888634]
  15. Antimicrob Agents Chemother. 2005 Jul;49(7):3034-9 [PMID: 15980394]
  16. Antimicrob Agents Chemother. 2003 Oct;47(10):3270-4 [PMID: 14506040]
  17. Diagn Microbiol Infect Dis. 2003 Sep;47(1):373-6 [PMID: 12967753]

MeSH Term

Anti-Bacterial Agents
Gram-Negative Bacteria
Gram-Positive Bacteria
Haemophilus influenzae
Microbial Sensitivity Tests
Staphylococcus aureus
Streptococcus pneumoniae
Streptogramins

Chemicals

Anti-Bacterial Agents
Streptogramins
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

Created with Highcharts 10.0.0NXL103×MIC5h2strainsGram-positive-negativebacteriaMICs1bactericidal2433003μg/ml12pneumococcigroupBβ-hemolyticstreptococci8HaemophilusinfluenzaeMoraxellacatarrhalis4mainlybacteriostaticmethicillin-resistantStaphylococcusaureusexposureonestrainspecies10dailysubculturesremainedwithin±dilutionTime-killactivitystreptogramin

Similar Articles

Cited By