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British journal of cancer
Feb 15, 2011;104 (4): 554-8.

Genome-wide functions of PML-RARα in acute promyelocytic leukaemia.

S Saeed, C Logie, H G Stunnenberg, J H A Martens
Author Information
  1. S Saeed: Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, The Netherlands.
PMID: 21245861 DOI: 10.1038/sj.bjc.6606095

Abstract

PML-RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

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MeSH Term

Animals
Epigenesis, Genetic
Genome, Human
Humans
Leukemia, Promyelocytic, Acute
Models, Biological
Oncogene Proteins, Fusion
Signal Transduction

Chemicals

Oncogene Proteins, Fusion
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
Journal Article Research Support, Non-U.S. Gov't Review

Word Cloud

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