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Gut microbes
Jan, 2010;1 (1): 22-29.

Good fences make good neighbors: Gastrointestinal mucosal structure.

Hannah L Turner, Jerrold R Turner
Author Information
  1. Hannah L Turner: Department of Pathology; The University of Chicago; Chicago, IL USA.
PMID: 21327113 DOI: 10.4161/gmic.1.1.11427

Abstract

The gastrointestinal lumen is home to over 400 species of microorganisms. The composition of this microbial community varies along the length of the gastrointestinal tract as a function of regional epithelial secretory activity as well as diet and other defined and undefined determinants. Improved understanding of the factors that impact luminal microbial populations and development of means to modulate gut microbes for therapeutic benefit hold great promise. The gastrointestinal epithelium, which regulates interactions between microbes and the mammalian host, is the topic of this review.

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Grants

  1. P01 DK067887/NIDDK NIH HHS
  2. R01 DK061931/NIDDK NIH HHS
  3. R01 DK068271/NIDDK NIH HHS
Journal Article
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Created with Highcharts 10.0.0gastrointestinalmicrobialmicrobeslumenhome400speciesmicroorganismscompositioncommunityvariesalonglengthtractfunctionregionalepithelialsecretoryactivitywelldietdefinedundefineddeterminantsImprovedunderstandingfactorsimpactluminalpopulationsdevelopmentmeansmodulateguttherapeuticbenefitholdgreatpromiseepitheliumregulatesinteractionsmammalianhosttopicreviewGoodfencesmakegoodneighbors:Gastrointestinalmucosalstructure

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