OpenLB
Open Library of Bioscience
Advanced Search
Arthritis research & therapy
Mar 18, 2011;13 (2): 208.

The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies.

Nadia Sassi, Lilia Laadhar, Maha Driss, Meriam Kallel-Sellami, Slaheddine Sellami, Sondes Makni
Author Information
  1. Nadia Sassi: Osteoarthritis-osteoporosis Research Laboratory, Rheumatology Department, LaRabta Hospital, 1007 Tunis, Tunisia. nadiasassitn@yahoo.com
PMID: 21457519 DOI: 10.1186/ar3255

Abstract

Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we report on studies that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of chondrocytes. Temporal and/or spatial modulation of this signaling pathway may help these cells to synthesize a new functional extracellular matrix and restore the functional properties of the articular cartilage.

References

  1. Acta Histochem. 2008;110(5):397-407 [PMID: 18272209]
  2. Neuron. 2000 Apr;26(1):1-2 [PMID: 10798384]
  3. Development. 1999 Feb;126(5):987-98 [PMID: 9927599]
  4. J Cell Physiol. 2003 Mar;194(3):237-55 [PMID: 12548545]
  5. Arthritis Rheum. 2009 Feb;60(2):428-39 [PMID: 19180482]
  6. Cell. 1980 Dec;22(3):777-85 [PMID: 6257398]
  7. Biorheology. 2006;43(3,4):447-54 [PMID: 16912416]
  8. EMBO J. 2006 Mar 8;25(5):1000-8 [PMID: 16498412]
  9. J Cell Sci. 2004 Feb 29;117(Pt 6):889-97 [PMID: 14762107]
  10. Curr Opin Genet Dev. 2002 Oct;12(5):524-33 [PMID: 12200157]
  11. J Anat. 2003 Jun;202(6):495-502 [PMID: 12846471]
  12. PLoS One. 2010 Oct 14;5(10):e13246 [PMID: 20976230]
  13. Nature. 2003 Oct 23;425(6960):841-6 [PMID: 14574413]
  14. J Cell Physiol. 2005 Mar;202(3):731-42 [PMID: 15389573]
  15. J Anat. 2009 Aug;215(2):159-69 [PMID: 19490397]
  16. Curr Top Microbiol Immunol. 1998;228:273-324 [PMID: 9401210]
  17. Genes Dev. 1998 Aug 1;12(15):2269-77 [PMID: 9694793]
  18. Nat Neurosci. 2005 Jun;8(6):709-15 [PMID: 15917835]
  19. Curr Biol. 2004 Feb 3;14(3):R129-38 [PMID: 14986688]
  20. Exp Cell Res. 2009 May 15;315(9):1549-55 [PMID: 18845146]
  21. J Endocrinol. 2007 Sep;194(3):459-74 [PMID: 17761886]
  22. Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii78-81 [PMID: 12379630]
  23. Pathol Res Pract. 2000;196(11):729-45 [PMID: 11186168]
  24. Biochim Biophys Acta. 2008 Sep;1782(9):489-97 [PMID: 18625307]
  25. Cell Stem Cell. 2008 Apr 10;2(4):356-66 [PMID: 18397755]
  26. Genes Dev. 1994 Nov 15;8(22):2743-55 [PMID: 7958930]
  27. Bone. 2010 Feb;46(2):286-93 [PMID: 19406255]
  28. Neuron. 1998 Apr;20(4):667-81 [PMID: 9581760]
  29. Mol Biol Cell. 2003 Feb;14(2):491-502 [PMID: 12589049]
  30. Cell. 1989 Jul 14;58(1):103-13 [PMID: 2502313]
  31. Arthritis Rheum. 2004 May;50(5):1522-32 [PMID: 15146422]
  32. Arthritis Rheum. 2003 May;48(5):1315-25 [PMID: 12746904]
  33. Biochim Biophys Acta. 1982 Sep 17;718(1):74-84 [PMID: 7138907]
  34. Osteoarthritis Cartilage. 2005 Mar;13(3):243-9 [PMID: 15727891]
  35. Science. 1995 Apr 14;268(5208):225-32 [PMID: 7716513]
  36. J Anat. 2006 Oct;209(4):469-80 [PMID: 17005019]
  37. EMBO J. 1999 Apr 15;18(8):2196-207 [PMID: 10205173]
  38. Virchows Arch A Pathol Anat Histol. 1980;389(2):167-87 [PMID: 7456325]
  39. Arthritis Res Ther. 2009;11(3):R85 [PMID: 19500336]
  40. Exp Cell Res. 2004 Jul 15;297(2):313-28 [PMID: 15212937]
  41. Biochem J. 1980 Jun 15;188(3):823-37 [PMID: 7470037]
  42. Nat Cell Biol. 2001 Oct;3(10):883-90 [PMID: 11584269]
  43. Arthritis Rheum. 2002 Jun;46(6):1536-43 [PMID: 12115184]
  44. Biotech Histochem. 2009 Dec;84(6):313-20 [PMID: 19562571]
  45. Curr Opin Cell Biol. 2001 Oct;13(5):627-34 [PMID: 11544033]
  46. Arthritis Rheum. 2008 Sep;58(9):2754-63 [PMID: 18759300]
  47. Exp Cell Res. 2005 Jun 10;306(2):343-8 [PMID: 15925590]
  48. J Cell Biol. 2001 Dec 24;155(7):1185-98 [PMID: 11756472]
  49. Arthritis Res Ther. 2003;5(2):94-103 [PMID: 12718749]
  50. Osteoarthritis Cartilage. 2005 Jun;13(6):537-44 [PMID: 15922188]
  51. Ultrastruct Pathol. 2002 Jan-Feb;26(1):33-40 [PMID: 12028657]
  52. Science. 1999 Apr 30;284(5415):770-6 [PMID: 10221902]
  53. Neuron. 1999 Feb;22(2):301-12 [PMID: 10069336]
  54. Endocr Rev. 2007 May;28(3):339-63 [PMID: 17409286]
  55. Biochim Biophys Acta. 1979 Mar 7;583(2):218-31 [PMID: 444563]
  56. Cells Tissues Organs. 2008;188(3):287-98 [PMID: 18354251]
  57. Nat Med. 2006 Aug;12(8):884-5 [PMID: 16892029]
  58. Osteoarthritis Cartilage. 2002 Dec;10(12):977-86 [PMID: 12464558]
  59. N Engl J Med. 2001 Apr 5;344(14):1031-7 [PMID: 11287972]
  60. Cell. 2000 Jun 23;101(7):717-28 [PMID: 10892743]
  61. Dev Biol. 2008 Jan 15;313(2):556-67 [PMID: 18062953]
  62. J Cell Physiol. 2008 Jan;214(1):75-83 [PMID: 17559082]
  63. Development. 1999 Apr;126(8):1689-702 [PMID: 10079231]
  64. Nature. 1987 Nov 26-Dec 2;330(6146):386-8 [PMID: 2825022]
  65. J Bone Miner Metab. 2003;21(6):344-52 [PMID: 14586790]
  66. Anat Embryol (Berl). 2001 Jun;203(6):469-79 [PMID: 11453164]
  67. Cell Tissue Res. 2007 Mar;327(3):539-51 [PMID: 17093926]
  68. Genetics. 1917 Sep;2(5):445-65 [PMID: 17245891]
  69. Cells Tissues Organs. 2010;191(1):2-11 [PMID: 19494482]
  70. Development. 2010 May;137(9):1461-71 [PMID: 20335360]
  71. Rev Med Interne. 2007 Aug;28(8):531-6 [PMID: 17316922]
  72. Histol Histopathol. 2006 Jul;21(7):793-802 [PMID: 16598678]
  73. Development. 1996 Dec;122(12):3765-73 [PMID: 9012498]

MeSH Term

Animals
Cartilage, Articular
Chondrocytes
Humans
Osteoarthritis
Receptors, Notch

Chemicals

Receptors, Notch
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0pathwayNotchcartilagearticularinvolvementsignalingpathologystudiesmodulationfunctionalOsteoarthritisprevalentformarthritisworldprogressiveageingpopulationbecomingmajorpublichealthproblemcertainpathwaysreportedreviewreportinvestigatedexpressionpatternfamilymemberseventualphysiologychondrocytesTemporaland/orspatialmayhelpcellssynthesizenewextracellularmatrixrestorepropertiesrolehealthyosteoarthriticcartilage:experimentalmodelsexvivo

Similar Articles

Cited By