OpenLB
Open Library of Bioscience
Advanced Search
World journal of gastroenterology
Apr 21, 2011;17 (15): 1939-46.

Perianal Crohn's disease: is there something new?

Cesare Ruffolo, Marilisa Citton, Marco Scarpa, Imerio Angriman, Marco Massani, Ezio Caratozzolo, Nicolò Bassi
Author Information
PMID: 21528071 DOI: 10.3748/wjg.v17.i15.1939

Abstract

Perianal lesions are common in patients with Crohn's disease, and display aggressive behavior in some cases. An accurate diagnosis is necessary for the optimal management of perianal lesions. Treatment of perianal Crohn's disease includes medical and/or surgical options. Recent discoveries in the pathogenesis of this disease have led to advances in medical and surgical therapy with good results. Perianal lesions in Crohn's disease remain a challenging aspect for both gastroenterologists and surgeons and lead to a greatly impaired quality of life for all patients affected by this disease. A multidisciplinary approach is mandatory to obtain the best results.

Keywords

Biologic therapy Crohn disease Diagnosis Rectal fistula Surgery

References

  1. Am J Gastroenterol. 2008 Dec;103(12):3082-93 [PMID: 19086959]
  2. Gastroenterology. 2003 Aug;125(2):380-8 [PMID: 12891539]
  3. Dis Colon Rectum. 1996 May;39(5):529-35 [PMID: 8620803]
  4. Gastroenterology. 2001 Nov;121(5):1064-72 [PMID: 11677197]
  5. Gut. 2006 Jun;55(6):749-53 [PMID: 16698746]
  6. Ann Surg. 2005 May;241(5):796-801; discussion 801-2 [PMID: 15849515]
  7. Colorectal Dis. 2004 Sep;6(5):308-19 [PMID: 15335361]
  8. Am J Gastroenterol. 2009 Dec;104(12):2973-86 [PMID: 19755971]
  9. Br J Surg. 2005 Apr;92(4):482-6 [PMID: 15736219]
  10. J Gastrointest Surg. 2007 Jan;11(1):16-21 [PMID: 17390181]
  11. Br J Surg. 2000 Aug;87(8):1063-6 [PMID: 10931051]
  12. N Engl J Med. 1999 May 6;340(18):1398-405 [PMID: 10228190]
  13. Ann Surg Innov Res. 2009 Nov 14;3:12 [PMID: 19912660]
  14. Gastroenterology. 2002 Apr;122(4):875-80 [PMID: 11910338]
  15. Scand J Gastroenterol. 2006 Sep;41(9):1064-72 [PMID: 16938720]
  16. Br J Surg. 2010 Sep;97(9):1340-7 [PMID: 20632322]
  17. Dis Colon Rectum. 1991 May;34(5):378-84 [PMID: 2022142]
  18. Inflamm Bowel Dis. 2009 May;15(5):742-9 [PMID: 19023861]
  19. Aliment Pharmacol Ther. 2008 Jan 1;27(1):19-30 [PMID: 17944997]
  20. World J Gastroenterol. 2009 Sep 14;15(34):4263-72 [PMID: 19750568]
  21. Aliment Pharmacol Ther. 2003 Dec;18(11-12):1113-20 [PMID: 14653831]
  22. N Engl J Med. 2007 Jul 19;357(3):239-50 [PMID: 17634459]
  23. N Engl J Med. 2007 Jul 19;357(3):228-38 [PMID: 17634458]
  24. Dis Colon Rectum. 2005 Apr;48(4):768-74 [PMID: 15768185]
  25. Aliment Pharmacol Ther. 2004 Dec;20(11-12):1329-36 [PMID: 15606395]
  26. N Engl J Med. 1999 Jan 21;340(3):239-40 [PMID: 9917236]
  27. Ann Intern Med. 1995 Jul 15;123(2):132-42 [PMID: 7778826]
  28. Dis Colon Rectum. 2006 Mar;49(3):371-6 [PMID: 16421664]
  29. Inflamm Bowel Dis. 2009 Jan;15(1):17-24 [PMID: 18668682]
  30. Inflamm Bowel Dis. 2010 Oct;16(10):1631 [PMID: 20848458]
  31. Aliment Pharmacol Ther. 2007 Feb 15;25(4):409-18 [PMID: 17269996]
  32. Ann Intern Med. 2001 Nov 20;135(10):906-18 [PMID: 11712881]
  33. World J Surg. 2000 Oct;24(10):1258-62; discussion 1262-3 [PMID: 11071472]
  34. Lancet. 2007 May 12;369(9573):1641-57 [PMID: 17499606]
  35. Gastroenterology. 1982 Aug;83(2):383-7 [PMID: 7084615]
  36. Br J Surg. 2009 Oct;96(10):1190-5 [PMID: 19688772]
  37. J Clin Gastroenterol. 1995 Jan;20(1):27-32 [PMID: 7884173]
  38. J Crohns Colitis. 2010 Feb;4(1):63-101 [PMID: 21122490]
  39. Gut. 1995 Nov;37(5):696-701 [PMID: 8549948]
  40. Nat Clin Pract Gastroenterol Hepatol. 2009 Feb;6(2):92-106 [PMID: 19153563]
  41. Colorectal Dis. 2005 Sep;7(5):513-8 [PMID: 16108891]
  42. J Gastrointest Surg. 2007 Apr;11(4):529-37 [PMID: 17436140]
  43. Gastroenterology. 1998 Jun;114(6):1151-60 [PMID: 9609751]
  44. Colorectal Dis. 2010 Dec;12(12):1183-91 [PMID: 19674019]
  45. J Gastrointest Surg. 2007 Jun;11(6):791-803 [PMID: 17562122]
  46. Radiology. 2006 Apr;239(1):18-33 [PMID: 16567481]
  47. Int J Colorectal Dis. 2007 Dec;22(12):1453-7 [PMID: 17583818]
  48. Br J Surg. 2005 Jun;92(6):740-1 [PMID: 15838906]
  49. Inflamm Bowel Dis. 2009 Oct;15(10):1591-8 [PMID: 19637358]
  50. Gastroenterology. 2006 Feb;130(2):323-33; quiz 591 [PMID: 16472588]
  51. Dig Liver Dis. 2007 Oct;39(10):959-62 [PMID: 17720634]
  52. Am Surg. 1998 Feb;64(2):147-50 [PMID: 9486887]
  53. Gastroenterology. 2006 Mar;130(3):650-6 [PMID: 16530505]
  54. Inflamm Bowel Dis. 2000 Feb;6(1):8-15 [PMID: 10701144]
  55. Ann Intern Med. 2007 Jun 19;146(12):829-38 [PMID: 17470824]
  56. Dis Colon Rectum. 2002 Dec;45(12):1616-21 [PMID: 12473884]
  57. N Engl J Med. 1997 Oct 9;337(15):1029-35 [PMID: 9321530]
  58. Inflamm Bowel Dis. 2007 Mar;13(3):245-53 [PMID: 17206671]
  59. Br J Surg. 1976 Jan;63(1):1-12 [PMID: 1267867]
  60. Aliment Pharmacol Ther. 2004 Feb 15;19(4):427-34 [PMID: 14871282]
  61. Dis Colon Rectum. 1992 Oct;35(10):928-32 [PMID: 1395978]
  62. Dig Liver Dis. 2007 Oct;39(10):970-8 [PMID: 17720640]
  63. Am J Surg. 1999 Oct;178(4):337-40 [PMID: 10587195]
  64. Clin Gastroenterol Hepatol. 2006 Sep;4(9):1130-4 [PMID: 16905369]
  65. Aliment Pharmacol Ther. 2001 Nov;15(11):1699-708 [PMID: 11683683]
  66. Dis Colon Rectum. 2009 Jan;52(1):79-86 [PMID: 19273960]
  67. Dig Liver Dis. 2007 Oct;39(10):963-9 [PMID: 17720635]
  68. N Engl J Med. 2005 May 26;352(21):2193-201 [PMID: 15917384]
  69. Gastroenterology. 2003 Nov;125(5):1508-30 [PMID: 14598268]
  70. J R Soc Med. 1978 Sep;71(9):644-51 [PMID: 712742]
  71. Am J Gastroenterol. 2008 Jul;103(7):1721-9 [PMID: 18616656]
  72. N Engl J Med. 2004 Feb 26;350(9):876-85 [PMID: 14985485]
  73. Inflamm Bowel Dis. 2004 Mar;10(2):91-6 [PMID: 15168807]
  74. Am J Surg. 2006 Mar;191(3):424-7 [PMID: 16490560]
  75. Inflamm Bowel Dis. 2008 Oct;14(10):1406-12 [PMID: 18452203]
  76. Br J Surg. 2004 Apr;91(4):476-80 [PMID: 15048751]
  77. Aliment Pharmacol Ther. 2007 Mar 1;25(5):557-67 [PMID: 17305756]
  78. Colorectal Dis. 2007 Oct;9 Suppl 4:18-50 [PMID: 17880382]
  79. Dis Colon Rectum. 2005 Jul;48(7):1416-23 [PMID: 15933795]
  80. Eur J Gastroenterol Hepatol. 2004 Sep;16(9):921-6 [PMID: 15316419]

MeSH Term

Anus Diseases
Clinical Trials as Topic
Crohn Disease
Cytokines
Humans

Chemicals

Cytokines
Editorial Review
Article has an altmetric score of 3

Word Cloud

Created with Highcharts 10.0.0diseaseCrohn'sPerianallesionspatientsperianalmedicalsurgicaltherapyresultscommondisplayaggressivebehaviorcasesaccuratediagnosisnecessaryoptimalmanagementTreatmentincludesand/oroptionsRecentdiscoveriespathogenesisledadvancesgoodremainchallengingaspectgastroenterologistssurgeonsleadgreatlyimpairedqualitylifeaffectedmultidisciplinaryapproachmandatoryobtainbestdisease:somethingnew?BiologicCrohnDiagnosisRectalfistulaSurgery

Similar Articles

Cited By