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Nature reviews. Neuroscience
06 02, 2011;12 (8): 479-84.

Differentiating the rapid actions of cocaine.

Roy A Wise, Eugene A Kiyatkin
Author Information
  1. Roy A Wise: US National Institute on Drug Abuse, Behavioral Neuroscience Section, 251 Bayview Boulevard. Baltimore, Maryland 21224, USA. rwise@intra.nida.nih.gov
PMID: 21633381 DOI: 10.1038/nrn3043

Abstract

The subjective effects of intravenous cocaine are felt almost immediately, and this immediacy plays an important part in the drug's rewarding impact. The primary rewarding effect of cocaine involves blockade of dopamine reuptake; however, the onset of this action is too late to account for the drug's initial effects. Recent studies suggest that cocaine-predictive cues--including peripheral interoceptive cues generated by cocaine itself--come to cause more direct and earlier reward signalling by activating excitatory inputs to the dopamine system. The conditioned activation of the dopamine system by cocaine-predictive cues offers a new target for potential addiction therapies.

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Grants

  1. ZIA DA000471/Intramural NIH HHS
  2. ZIA DA000471-07/Intramural NIH HHS
  3. ZIA DA000566-01/Intramural NIH HHS

MeSH Term

Animals
Brain
Cocaine
Humans
Rats
Reinforcement, Psychology
Self Administration

Chemicals

Cocaine
Journal Article Research Support, N.I.H., Intramural
Article has an altmetric score of 2

Word Cloud

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