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Frontiers in pharmacology
2011;2 56.

MEGen: A Physiologically Based Pharmacokinetic Model Generator.

George Loizou, Alex Hogg
Author Information
  1. George Loizou: Health and Safety Laboratory Buxton, UK.
PMID: 22084631 DOI: 10.3389/fphar.2011.00056

Abstract

Physiologically based pharmacokinetic models are being used in an increasing number of different areas. However, they are perceived as complex, data hungry, resource intensive, and time consuming. In addition, model validation and verification are hindered by the relative complexity of the equations. To begin to address these issues a web application called MEGen for the rapid construction and documentation of bespoke deterministic PBPK model code is under development. MEGen comprises a parameter database and a model code generator that produces code for use in several commercial software packages and one that is freely available. Here we present an overview of the current capabilities of MEGen, and discuss future developments.

Keywords

database equation generator pharmacokinetic physiologically based

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Journal Article
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