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Infectious diseases in obstetrics and gynecology
2011;2011 842652.

Association between semen exposure and incident bacterial vaginosis.

Maria F Gallo, Lee Warner, Caroline C King, Jack D Sobel, Robert S Klein, Susan Cu-Uvin, Anne M Rompalo, Denise J Jamieson
Author Information
  1. Maria F Gallo: Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA. mgallo@cdc.gov
PMID: 22190844 DOI: 10.1155/2011/842652

Abstract

OBJECTIVE. To identify correlates of incident bacterial vaginosis (BV) diagnosed with Nugent scoring among high-risk women. STUDY DESIGN. We conducted both cohort and case-crossover analyses, stratified by HIV infection status, based on 871 HIV-infected and 439 HIV-uninfected participants in the HIV Epidemiology Research Study, conducted in 4 US sites in 1993-2000. RESULTS. BV incidence was 21% and 19% among HIV-infected and -uninfected women, respectively. Fewer correlates of BV were found with case-crossover than with cohort design. Reporting frequent coitus (regardless of consistency of condom use) was correlated with BV in cohort analyses but not in case-crossover analyses. The sole correlate of BV in both types of analyses was the detection of spermatozoa on Gram stain, which is a marker of semen exposure. CONCLUSION. The inconsistent association between condom use and BV in prior studies could be from reporting bias. We found evidence of a relationship between semen exposure and incident BV.

References

  1. Am J Obstet Gynecol. 2008 Jun;198(6):628.e1-7 [PMID: 18295180]
  2. JAMA. 1986 Oct 10;256(14):1899-903 [PMID: 3761496]
  3. Obstet Gynecol. 2001 Oct;98(4):656-63 [PMID: 11576584]
  4. Pediatrics. 2011 Feb;127(2):208-13 [PMID: 21199852]
  5. Sex Transm Dis. 2007 Dec;34(12):954-9 [PMID: 18077845]
  6. Int J STD AIDS. 2008 Mar;19(3):152-4 [PMID: 18397551]
  7. BMJ. 1999 Jul 24;319(7204):220-3 [PMID: 10417083]
  8. Am J Obstet Gynecol. 1988 Apr;158(4):935-9 [PMID: 3259076]
  9. Sex Transm Dis. 2008 Jul;35(7):643-8 [PMID: 18580455]
  10. J Infect Dis. 2005 Apr 1;191(7):1129-39 [PMID: 15747249]
  11. Int J STD AIDS. 2009 Nov;20(11):778-81 [PMID: 19833694]
  12. Am J Epidemiol. 2005 Sep 15;162(6):585-90 [PMID: 16093289]
  13. Am J Epidemiol. 1991 Jan 15;133(2):144-53 [PMID: 1985444]
  14. J Infect Dis. 2010 Dec 15;202(12):1907-15 [PMID: 21067371]
  15. J Obstet Gynaecol. 2005 Nov;25(8):751-3 [PMID: 16368577]
  16. Am J Epidemiol. 1997 Sep 15;146(6):459-69 [PMID: 9290506]
  17. Clin Infect Dis. 2008 Dec 1;47(11):1426-35 [PMID: 18947329]
  18. Am J Reprod Immunol. 2008 Sep;60(3):274-81 [PMID: 18647289]
  19. J Clin Microbiol. 1991 Feb;29(2):297-301 [PMID: 1706728]
  20. Obstet Gynecol. 2004 Oct;104(4):761-9 [PMID: 15458899]
  21. Sex Transm Dis. 2010 Dec;37(12):732-44 [PMID: 21068695]
  22. BMJ. 1994 Jan 29;308(6924):295-8 [PMID: 8124116]
  23. Am J Obstet Gynecol. 2003 Jul;189(1):139-47 [PMID: 12861153]
  24. Sex Transm Infect. 2010 Aug;86(4):297-302 [PMID: 20660593]
  25. Sex Transm Dis. 2007 Nov;34(11):864-9 [PMID: 17621244]
  26. AIDS. 2008 Jul 31;22(12):1493-501 [PMID: 18614873]
  27. Clin Infect Dis. 2003 Aug 1;37(3):319-25 [PMID: 12884154]
  28. Acta Obstet Gynecol Scand. 2006;85(8):906-11 [PMID: 16862466]
  29. Clin Infect Dis. 2003 Mar 1;36(5):663-8 [PMID: 12594649]
  30. Am J Obstet Gynecol. 2006 Feb;194(2):381-6 [PMID: 16458633]
  31. Trop Med Int Health. 2009 Apr;14(4):480-6 [PMID: 19222825]
  32. Epidemiology. 2007 Nov;18(6):702-8 [PMID: 17917605]
  33. J Infect Dis. 2007 Dec 1;196(11):1692-7 [PMID: 18008255]
  34. Am J Obstet Gynecol. 1997 Nov;177(5):1184-7 [PMID: 9396917]
  35. JAMA. 1978 Oct 20;240(17):1875-7 [PMID: 567701]
  36. Forensic Sci. 1974 Feb;3(1):45-55 [PMID: 4426545]
  37. Genitourin Med. 1997 Feb;73(1):23-8 [PMID: 9155551]
  38. Obstet Gynecol. 2003 Nov;102(5 Pt 1):927-33 [PMID: 14672465]
  39. Sex Transm Dis. 2008 Jun;35(6):617-23 [PMID: 18418290]
  40. Obstet Gynecol. 1992 Nov;80(5):878-83 [PMID: 1407933]
  41. N Engl J Med. 1995 Dec 28;333(26):1737-42 [PMID: 7491137]
  42. J Clin Microbiol. 1990 Sep;28(9):2035-9 [PMID: 2229386]

Grants

  1. U64/CCU106795/PHS HHS
  2. U64/CCU206798/PHS HHS
  3. U64/CCU306802/PHS HHS
  4. U64/CCU506831/PHS HHS

MeSH Term

AIDS-Related Opportunistic Infections
Cohort Studies
Cross-Over Studies
Female
HIV Infections
HIV Seronegativity
Humans
Incidence
Pregnancy
Semen
United States
Unsafe Sex
Vaginal Smears
Vaginosis, Bacterial
Journal Article Research Support, U.S. Gov't, P.H.S.
Article has an altmetric score of 3

Word Cloud

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