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Nature reviews. Cardiology
Feb 14, 2012;9 (4): 234-42.

Sex-related differences in patients' responses to heart failure therapy.

Alon Barsheshet, Andrew Brenyo, Ilan Goldenberg, Arthur J Moss
Author Information
  1. Alon Barsheshet: Cardiology Division, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
PMID: 22330611 DOI: 10.1038/nrcardio.2012.10

Abstract

Men and women with heart failure display important differences in clinical characteristics that might affect their responses to pharmacological and nonpharmacological therapies. In women, heart failure is associated with a higher frequency of hypertension, nonischemic cardiomyopathy and left bundle branch block than in men. Subgroup analyses of data from randomized clinical trials suggest that these differences result in a differential response to heart failure therapies, including a somewhat better response to β-blockers, a worse prognosis with digoxin therapy, and a lower survival benefit with implantable cardioverter-defibrillators in women. Importantly, female patients with heart failure also derive significantly greater improvements in cardiac volumes from cardiac resynchronization therapy than do male patients, and this treatment is associated with reduced risks of all-cause mortality and heart failure events among women with mild symptoms. These data suggest that sex-related differences might exist in response to both medical and device therapies for patients with heart failure.

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MeSH Term

Cardiac Resynchronization Therapy
Cardiovascular Agents
Defibrillators, Implantable
Electric Countershock
Evidence-Based Medicine
Female
Health Status Disparities
Heart Failure
Humans
Male
Risk Assessment
Risk Factors
Sex Factors
Treatment Outcome

Chemicals

Cardiovascular Agents
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 1

Word Cloud

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