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Bacteriophage
Mar, 2011;1 (2): 66-85.

Phage treatment of human infections.

Stephen T Abedon, Sarah J Kuhl, Bob G Blasdel, Elizabeth Martin Kutter
Author Information
  1. Stephen T Abedon: Department of Microbiology; The Ohio State University; Mansfield, OH USA.
PMID: 22334863 DOI: 10.4161/bact.1.2.15845

Abstract

Phages as bactericidal agents have been employed for 90 years as a means of treating bacterial infections in humans as well as other species, a process known as phage therapy. In this review we explore both the early historical and more modern use of phages to treat human infections. We discuss in particular the little-reviewed French early work, along with the Polish, US, Georgian and Russian historical experiences. We also cover other, more modern examples of phage therapy of humans as differentiated in terms of disease. In addition, we provide discussions of phage safety, other aspects of phage therapy pharmacology, and the idea of phage use as probiotics.

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