A 'snip' in time: what is the best age to circumcise?

Brian J Morris, Jake H Waskett, Joya Banerjee, Richard G Wamai, Aaron A R Tobian, Ronald H Gray, Stefan A Bailis, Robert C Bailey, Jeffrey D Klausner, Robin J Willcourt, Daniel T Halperin, Thomas E Wiswell, Adrian Mindel
Author Information
  1. Brian J Morris: School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia. brian.morris@sydney.edu.au

Abstract

BACKGROUND: Circumcision is a common procedure, but regional and societal attitudes differ on whether there is a need for a male to be circumcised and, if so, at what age. This is an important issue for many parents, but also pediatricians, other doctors, policy makers, public health authorities, medical bodies, and males themselves.
DISCUSSION: We show here that infancy is an optimal time for clinical circumcision because an infant's low mobility facilitates the use of local anesthesia, sutures are not required, healing is quick, cosmetic outcome is usually excellent, costs are minimal, and complications are uncommon. The benefits of infant circumcision include prevention of urinary tract infections (a cause of renal scarring), reduction in risk of inflammatory foreskin conditions such as balanoposthitis, foreskin injuries, phimosis and paraphimosis. When the boy later becomes sexually active he has substantial protection against risk of HIV and other viral sexually transmitted infections such as genital herpes and oncogenic human papillomavirus, as well as penile cancer. The risk of cervical cancer in his female partner(s) is also reduced. Circumcision in adolescence or adulthood may evoke a fear of pain, penile damage or reduced sexual pleasure, even though unfounded. Time off work or school will be needed, cost is much greater, as are risks of complications, healing is slower, and stitches or tissue glue must be used.
SUMMARY: Infant circumcision is safe, simple, convenient and cost-effective. The available evidence strongly supports infancy as the optimal time for circumcision.

References

  1. PLoS Med. 2009 Sep;6(9):e1000109 [PMID: 19901974]
  2. Sex Transm Dis. 2011 Jun;38(6):571 [PMID: 21836398]
  3. N Engl J Med. 1997 Apr 24;336(17):1244-5 [PMID: 9110914]
  4. J Urol. 2006 Mar;175(3 Pt 1):1111-5 [PMID: 16469634]
  5. J Sex Med. 2009 Oct;6(10):2888-95 [PMID: 19627471]
  6. Bull World Health Organ. 2010 Dec 1;88(12):907-14 [PMID: 21124715]
  7. JAMA. 2008 Oct 8;300(14):1674-84 [PMID: 18840841]
  8. Br J Vener Dis. 1975 Aug;51(4):274-7 [PMID: 1156848]
  9. CMAJ. 2011 Apr 19;183(7):872 [PMID: 21422123]
  10. Genitourin Med. 1996 Jun;72(3):155-9 [PMID: 8707315]
  11. J Sex Med. 2009 Aug;6(8):2237-43 [PMID: 19453887]
  12. Acta Neurol Belg. 2008 Sep;108(3):90-3 [PMID: 19115671]
  13. Sex Transm Dis. 2003 May;30(5):405-10 [PMID: 12916131]
  14. PLoS Med. 2010 Jul 20;7(7):e1000309 [PMID: 20652013]
  15. BJU Int. 2007 Jul;100(1):5-6 [PMID: 17419695]
  16. Lancet. 2011 Jan 15;377(9761):209-18 [PMID: 21216000]
  17. Int J Cancer. 2011 Dec 15;129(12):2970-5 [PMID: 21462185]
  18. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011 Jun;33(3):313-7 [PMID: 21718616]
  19. Am J Public Health. 2009 Jan;99(1):138-45 [PMID: 19008503]
  20. J Urol. 2002 May;167(5):2113-6 [PMID: 11956453]
  21. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2683-91 [PMID: 18843010]
  22. J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):238-40 [PMID: 19155772]
  23. Arch Dis Child. 2003 May;88(5):444-5 [PMID: 12716722]
  24. J Urol. 2006 Nov;176(5):2315-6; author reply 2317-9 [PMID: 17070332]
  25. Am J Dis Child. 1986 Mar;140(3):254-6 [PMID: 3946358]
  26. Can Fam Physician. 2007 Dec;53(12):2096-8, 2100-2 [PMID: 18077736]
  27. Cochrane Database Syst Rev. 2011 Jun 15;(6):CD007496 [PMID: 21678366]
  28. J Fam Plann Reprod Health Care. 2009 Jan;35(1):5-7 [PMID: 19126309]
  29. Pediatrics. 2001 Feb;107(2):E20 [PMID: 11158494]
  30. AIDS. 2010 Mar 13;24(5):737-44 [PMID: 20042848]
  31. N Engl J Med. 2009 Mar 26;360(13):1298-309 [PMID: 19321868]
  32. Arch Dis Child. 2005 Aug;90(8):772-3 [PMID: 16040868]
  33. Urol Int. 2005;75(1):62-6 [PMID: 16037710]
  34. Pediatrics. 2005 Sep;116(3):644-8 [PMID: 16140703]
  35. PLoS Med. 2010 Jan 19;7(1):e1000219 [PMID: 20098515]
  36. PLoS One. 2008 Jun 18;3(6):e2443 [PMID: 18560581]
  37. J Urol. 1992 Nov;148(5 Pt 2):1726-32 [PMID: 1331545]
  38. J Eur Acad Dermatol Venereol. 2012 Jun;26(6):730-7 [PMID: 21707769]
  39. J Sex Med. 2005 Jul;2(4):492-7 [PMID: 16422843]
  40. Med Microbiol Immunol. 2004 Feb;193(1):35-44 [PMID: 12838415]
  41. Eur Urol. 1985;11(3):184-7 [PMID: 4029234]
  42. J Infect Dis. 2010 May 15;201(10):1455-62 [PMID: 20370483]
  43. J Infect Dis. 2009 Dec 15;200(12):1813-9 [PMID: 19911990]
  44. J Infect Dis. 2009 Apr 1;199(7):945-9 [PMID: 19220138]
  45. N Engl J Med. 2002 Apr 11;346(15):1105-12 [PMID: 11948269]
  46. Pediatrics. 1988 Apr;81(4):537-41 [PMID: 3353186]
  47. J Adolesc Health. 1992 Jun;13(4):293-7 [PMID: 1610845]
  48. Int Perspect Sex Reprod Health. 2010 Sep;36(3):157-8 [PMID: 20880801]
  49. J Urol. 2002 May;167(5):2111-2 [PMID: 11956452]
  50. Scand J Urol Nephrol. 1986;20(2):89-92 [PMID: 3749823]
  51. AIDS. 2008 May 11;22(8):983-8 [PMID: 18453858]
  52. AIDS. 2007 Apr 23;21(7):845-50 [PMID: 17415039]
  53. Sex Transm Dis. 2008 Jan;35(1):78-83 [PMID: 17989585]
  54. Andrologia. 1999;31 Suppl 1:3-11 [PMID: 10643512]
  55. Am J Bioeth. 2003 Spring;3(2):35-48 [PMID: 12859815]
  56. J Sex Med. 2008 Nov;5(11):2610-22 [PMID: 18761593]
  57. Rev Invest Clin. 2008 May-Jun;60(3):227-30 [PMID: 18807735]
  58. Adv Urol. 2011;2011:812368 [PMID: 21687572]
  59. Bioessays. 2007 Nov;29(11):1147-58 [PMID: 17935209]
  60. Sex Transm Dis. 2010 Jun;37(6):352-5 [PMID: 20145588]
  61. BMJ. 2001 Aug 11;323(7308):334-6 [PMID: 11498496]
  62. S Afr Med J. 2008 Oct;98(10):789-94 [PMID: 19115756]
  63. Aust N Z J Public Health. 2010 Apr;34(2):160-4 [PMID: 23331360]
  64. Int J Behav Med. 2012 Sep;19(3):336-41 [PMID: 21638159]
  65. Reprod Health Matters. 2007 May;15(29):53-6 [PMID: 17512375]
  66. PLoS One. 2010 Mar 10;5(3):e9628 [PMID: 20224784]
  67. PLoS Med. 2010 Jan 19;7(1):e1000211 [PMID: 20098721]
  68. JAMA. 1997 Apr 2;277(13):1052-7 [PMID: 9091693]
  69. Am J Obstet Gynecol. 2009 Jan;200(1):42.e1-7 [PMID: 18976733]
  70. Pediatr Infect Dis J. 2008 Apr;27(4):302-8 [PMID: 18316994]
  71. Pediatrics. 2006 May;117(5):1695-701 [PMID: 16651326]
  72. Lancet. 2007 Feb 24;369(9562):657-66 [PMID: 17321311]
  73. AIDS. 2008 Mar 12;22(5):567-74 [PMID: 18316997]
  74. PLoS Med. 2005 Nov;2(11):e298 [PMID: 16231970]
  75. Public Health Rep. 2010 Jan-Feb;125 Suppl 1:72-82 [PMID: 20408390]
  76. J Perinatol. 2009 Jan;29(1):44-50 [PMID: 18769380]
  77. PLoS Med. 2008 Jun 3;5(6):e116 [PMID: 18532873]
  78. Urology. 2005 Apr;65(4):773-7 [PMID: 15833526]
  79. PLoS Med. 2006 Jul;3(7):e262 [PMID: 16822094]
  80. PLoS One. 2008 Jul 16;3(7):e2731 [PMID: 18628946]
  81. Psychol Rep. 1976 Apr;38(2):485-6 [PMID: 1265180]
  82. Int J Gen Med. 2011;4:511-3 [PMID: 21845057]
  83. Clin Pediatr (Phila). 1999 Apr;38(4):239-42 [PMID: 10326180]
  84. Sex Transm Infect. 2006 Apr;82(2):101-9; discussion 110 [PMID: 16581731]
  85. Sex Transm Infect. 2010 Oct;86(5):404-6 [PMID: 20595141]
  86. Sex Transm Dis. 2010 Mar;37(3):147-52 [PMID: 19901865]
  87. JAMA. 1992 Feb 5;267(5):679-81 [PMID: 1472171]
  88. BJU Int. 2009 Dec;104(11):1698-701 [PMID: 19522862]
  89. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD003362 [PMID: 19370585]
  90. Med Sci Monit. 2007 Dec;13(12):RA205-13 [PMID: 18049444]
  91. J Sex Med. 2007 May;4(3):667-674 [PMID: 17419812]
  92. Cancer Causes Control. 2011 Aug;22(8):1097-110 [PMID: 21695385]
  93. J Med Ethics. 2007 Jun;33(6):357-61 [PMID: 17526688]
  94. AIDS. 2010 Oct;24 Suppl 4:S61-9 [PMID: 21042054]
  95. Am J Prev Med. 2010 Nov;39(5):479-82 [PMID: 20965388]
  96. BJU Int. 2008 Jan;101(1):65-70 [PMID: 18086100]
  97. Urol Clin North Am. 1983 Aug;10(3):543-9 [PMID: 6623741]
  98. Sex Transm Infect. 2008 Jun;84(3):158-60 [PMID: 18283093]
  99. Asian J Androl. 2010 Sep;12(5):628-38 [PMID: 20639909]
  100. Isr Med Assoc J. 2005 Jun;7(6):368-70 [PMID: 15984378]
  101. Clin Pediatr (Phila). 2004 Sep;43(7):667-9 [PMID: 15378157]
  102. J Infect Dis. 2010 May 15;201(10):1447-9 [PMID: 20370482]
  103. Clin Pediatr (Phila). 2010 Feb;49(2):130-6 [PMID: 20080519]
  104. J Infect Dis. 2009 Jan 1;199(1):14-9 [PMID: 19086814]
  105. BJU Int. 2009 Apr;103(8):1096-103 [PMID: 19245445]
  106. Pain. 2005 Feb;113(3):347-353 [PMID: 15661443]
  107. Urology. 2010 Jul;76(1):18-20 [PMID: 20381835]
  108. Urology. 2009 Jul;74(1):10-4 [PMID: 19395004]
  109. BMC Public Health. 2009 Nov 18;9 Suppl 1:S5 [PMID: 19922689]
  110. Int J STD AIDS. 2006 Aug;17(8):547-54 [PMID: 16925903]
  111. Sex Transm Dis. 2011 Jun;38(6):536-42 [PMID: 21217414]
  112. S Afr Med J. 2010 Jan 29;100(2):84-6 [PMID: 20459904]
  113. Afr J AIDS Res. 2008 May;7(1):1-8 [PMID: 25871266]
  114. AIDS Patient Care STDS. 2009 May;23(5):315-21 [PMID: 19335172]
  115. J Infect Dis. 2009 Dec 15;200(12):1803-12 [PMID: 19909084]
  116. J Pediatr Urol. 2011 Jun;7(3):324-31 [PMID: 21527214]
  117. Arch Dermatol. 2000 Mar;136(3):350-4 [PMID: 10724196]
  118. PLoS One. 2009 Nov 02;4(11):e7687 [PMID: 19888322]
  119. N Engl J Med. 1997 Apr 24;336(17):1197-201 [PMID: 9110906]
  120. Arch Pediatr Adolesc Med. 2010 Jan;164(1):78-84 [PMID: 20048246]
  121. Am J Med. 2002 Jul 8;113 Suppl 1A:55S-66S [PMID: 12113872]
  122. Int J STD AIDS. 2005 Aug;16(8):556-9 [PMID: 16105191]
  123. Prev Med. 2011 Mar-Apr;52(3-4):270-3 [PMID: 21295064]
  124. Int J Epidemiol. 2011 Oct;40(5):1367-81 [PMID: 21672947]
  125. J Acquir Immune Defic Syndr. 2011 May 1;57(1):e7-12 [PMID: 21346586]
  126. Int J Impot Res. 2007 Jul-Aug;19(4):424-31 [PMID: 17314981]
  127. J Infect Dis. 2010 Dec 15;202(12):1789-99 [PMID: 21067372]
  128. BMC Infect Dis. 2006 Nov 30;6:172 [PMID: 17137513]
  129. Clin Microbiol Rev. 2005 Apr;18(2):417-22 [PMID: 15831830]
  130. J Natl Med Assoc. 2009 Apr;101(4):325-30 [PMID: 19397222]
  131. Sex Transm Dis. 2011 Apr;38(4):353-5 [PMID: 21085057]
  132. PLoS One. 2010 Jan 18;5(1):e8723 [PMID: 20090910]
  133. AIDS. 2009 Jul 31;23(12):1557-64 [PMID: 19571722]
  134. Sex Transm Infect. 2011 Mar;87(2):88-93 [PMID: 20966458]
  135. J Sex Med. 2008 Nov;5(11):2557-61 [PMID: 18422492]
  136. Am J Public Health. 2009 Jun;99(6):969-71 [PMID: 19372502]
  137. Lancet. 2007 Feb 24;369(9562):643-56 [PMID: 17321310]
  138. Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Mar;31(3):281-5 [PMID: 20510053]
  139. BJU Int. 2008 Feb;101(3):338-40 [PMID: 18005214]
  140. Pediatrics. 2000 Jan;105(1 Pt 3):246-9 [PMID: 10617731]
  141. Pediatrics. 2000 Apr;105(4 Pt 1):860-2 [PMID: 10742334]
  142. BMJ. 1989 Sep 16;299(6701):703-6 [PMID: 2508881]
  143. Aust Fam Physician. 1996 Jan;Suppl 1:S30-4 [PMID: 9479796]
  144. Pediatrics. 1985 May;75(5):901-3 [PMID: 3991278]
  145. J Pain Symptom Manage. 2001 Jul;22(1):600-9 [PMID: 11516602]
  146. BMC Urol. 2010 Feb 16;10:2 [PMID: 20158883]
  147. Front Behav Neurosci. 2009 Sep 30;3:31 [PMID: 19862348]
  148. J Androl. 2010 Nov-Dec;31(6):540-6 [PMID: 20671139]
  149. AIDS Care. 2011 Nov;23(11):1472-82 [PMID: 21732901]
  150. Can Med Assoc J. 1947 Jan;56(1):54-6 [PMID: 20277522]
  151. Nat Rev Urol. 2009 Jun;6(6):298-9 [PMID: 19498404]
  152. J Sex Med. 2008 Nov;5(11):2481-4 [PMID: 19006492]
  153. Med J Aust. 2010 Sep 20;193(6):318-9 [PMID: 20854234]
  154. Arch Dis Child. 2005 Aug;90(8):853-8 [PMID: 15890696]
  155. Pediatrics. 1989 Jun;83(6):1011-5 [PMID: 2562792]
  156. Lancet Infect Dis. 2009 Nov;9(11):669-77 [PMID: 19850225]
  157. Clin Pediatr (Phila). 2007 May;46(4):329-33 [PMID: 17475991]
  158. Pediatrics. 2000 Apr;105(4 Pt 1):789-93 [PMID: 10742321]
  159. Ann R Coll Surg Engl. 1999 May;81(3):179-82 [PMID: 10364950]
  160. PLoS One. 2011;6(5):e19814 [PMID: 21603622]
  161. J Infect Dis. 2010 May 15;201(10):1463-9 [PMID: 20370481]
  162. Am J Epidemiol. 2005 Nov 1;162(9):907-16 [PMID: 16177149]
  163. ANZ J Surg. 2008 Nov;78(11):1019-22 [PMID: 18959705]
  164. Int J Epidemiol. 2012 Feb;41(1):310-2; author reply 312-4 [PMID: 22422464]
  165. AIDS Behav. 2007 May;11(3):341-55 [PMID: 17053855]
  166. Arch Dermatol. 1990 Aug;126(8):1046-7 [PMID: 2383029]
  167. AIDS Care. 2012;24(2):157-66 [PMID: 21854351]
  168. Urology. 2004 Jan;63(1):155-8 [PMID: 14751371]
  169. MMWR Morb Mortal Wkly Rep. 2010 Apr 23;59(15):456-9 [PMID: 20414188]

MeSH Term

Adolescent
Adult
Age Factors
Circumcision, Male
Culture
Humans
Infant
Male
Penile Diseases
Risk Assessment
Sexually Transmitted Diseases
Urinary Tract Infections

Word Cloud

Created with Highcharts 10.0.0circumcisionriskCircumcisionagealsoinfancyoptimaltimehealingcomplicationsinfectionsforeskinsexuallypenilecancerreducedBACKGROUND:commonprocedureregionalsocietalattitudesdifferwhetherneedmalecircumcisedimportantissuemanyparentspediatriciansdoctorspolicymakerspublichealthauthoritiesmedicalbodiesmalesthemselvesDISCUSSION:showclinicalinfant'slowmobilityfacilitatesuselocalanesthesiasuturesrequiredquickcosmeticoutcomeusuallyexcellentcostsminimaluncommonbenefitsinfantincludepreventionurinarytractcauserenalscarringreductioninflammatoryconditionsbalanoposthitisinjuriesphimosisparaphimosisboylaterbecomesactivesubstantialprotectionHIVviraltransmittedgenitalherpesoncogenichumanpapillomaviruswellcervicalfemalepartnersadolescenceadulthoodmayevokefearpaindamagesexualpleasureeventhoughunfoundedTimeworkschoolwillneededcostmuchgreaterrisksslowerstitchestissuegluemustusedSUMMARY:Infantsafesimpleconvenientcost-effectiveavailableevidencestronglysupports'snip'time:bestcircumcise?

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