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Current opinion in virology
Apr, 2012;2 (2): 151-6.

Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses.

Kathryn M Hastie, Shridhar Bale, Christopher R Kimberlin, Erica Ollmann Saphire
Author Information
  1. Kathryn M Hastie: Dept. of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
PMID: 22482712 DOI: 10.1016/j.coviro.2012.01.003

Abstract

The innate immune system is one of the first lines of defense against invading pathogens. Pathogens have, in turn, evolved different strategies to counteract these responses. Recent studies have illuminated how the hemorrhagic fever viruses Ebola and Lassa fever prevent host sensing of double-stranded RNA (dsRNA), a key hallmark of viral infection. The ebolavirus protein VP35 adopts a unique bimodal configuration to mask key cellular recognition sites on dsRNA. Conversely, the Lassa fever virus nucleoprotein actually digests the dsRNA signature. Collectively, these structural and functional studies shed new light on the mechanisms of pathogenesis of these viruses and provide new targets for therapeutic intervention.

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Grants

  1. T32 AI007606/NIAID NIH HHS
  2. T32 HL007731/NHLBI NIH HHS
  3. HHSN272200900049C/NIAID NIH HHS
  4. AI2008031/NIAID NIH HHS
  5. 5T32AI00760/NIAID NIH HHS

MeSH Term

Animals
Ebolavirus
Hemorrhagic Fevers, Viral
Humans
Immune Evasion
Immunity, Innate
Lassa virus
Viral Proteins

Chemicals

Viral Proteins
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 3

Word Cloud

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