Henipavirus outbreaks to antivirals: the current status of potential therapeutics.

Christopher C Broder
Author Information
  1. Christopher C Broder: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, United States. cbroder@usuhs.mil

Abstract

The henipaviruses, Hendra virus and Nipah virus, are classic examples of recently emerged viral zoonoses. In a relatively short time since their discoveries in the mid and late 1990s, respectively, a great deal of new information has been accumulated detailing their biology and certain unique characteristics. Their broad species tropism and abilities to cause severe and often fatal respiratory and/or neurologic disease in both animals and humans has sparked considerable interest in developing effective antiviral strategies to prevent or treat henipavirus infection and disease. Here, recent findings on the few most advanced henipavirus countermeasures are summarized and discussed.

References

  1. Nat Rev Microbiol. 2006 Jan;4(1):23-35 [PMID: 16357858]
  2. Acta Neuropathol. 2010 Sep;120(3):317-25 [PMID: 20652579]
  3. J Virol. 2009 May;83(10):5148-55 [PMID: 19264786]
  4. Lancet. 1997 Jan 11;349(9045):93-5 [PMID: 8996421]
  5. PLoS One. 2011;6(9):e25275 [PMID: 21980413]
  6. Aust Vet J. 1996 Sep;74(3):243-4 [PMID: 8894043]
  7. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9953-8 [PMID: 18632560]
  8. Aust Vet J. 1998 Dec;76(12):813-8 [PMID: 9972433]
  9. J Clin Virol. 2003 Apr;26(3):265-75 [PMID: 12637075]
  10. J Infect Dis. 2008 Mar 15;197(6):846-53 [PMID: 18271743]
  11. Trends Microbiol. 2011 Aug;19(8):389-99 [PMID: 21511478]
  12. Vector Borne Zoonotic Dis. 2012 Jan;12(1):65-72 [PMID: 21923274]
  13. Expert Rev Anti Infect Ther. 2006 Feb;4(1):43-55 [PMID: 16441208]
  14. Patholog Res Int. 2011;2011:567248 [PMID: 21961078]
  15. J Virol Methods. 2007 Jun;142(1-2):29-40 [PMID: 17292974]
  16. Immunotherapy. 2010 Mar;2(2):137-40 [PMID: 20635920]
  17. Nat Protoc. 2009;4(3):363-71 [PMID: 19247286]
  18. J Virol. 2005 Jun;79(11):6690-702 [PMID: 15890907]
  19. PLoS Pathog. 2010 Jun 24;6(6):e1000881 [PMID: 20585631]
  20. Am J Trop Med Hyg. 2011 Nov;85(5):946-51 [PMID: 22049055]
  21. PLoS Pathog. 2009 Oct;5(10):e1000642 [PMID: 19888339]
  22. Vaccine. 2011 Aug 5;29(34):5623-30 [PMID: 21689706]
  23. Sci Transl Med. 2011 Oct 19;3(105):105ra103 [PMID: 22013123]
  24. J Virol. 2004 Sep;78(17):9154-63 [PMID: 15308711]
  25. Ann Neurol. 2001 Jun;49(6):810-3 [PMID: 11409437]
  26. J Virol. 2006 Jan;80(2):891-9 [PMID: 16378991]
  27. J Comp Pathol. 2007 May;136(4):266-72 [PMID: 17498518]
  28. J Virol. 2006 Aug;80(16):7929-38 [PMID: 16873250]
  29. J Virol. 2008 Dec;82(23):11628-36 [PMID: 18815311]
  30. Nat Struct Mol Biol. 2008 Jun;15(6):567-72 [PMID: 18488039]
  31. Emerg Infect Dis. 2010 Feb;16(2):219-23 [PMID: 20113550]
  32. Emerg Infect Dis. 2011 Dec;17(12):2232-8 [PMID: 22172152]
  33. Antimicrob Agents Chemother. 2006 May;50(5):1768-72 [PMID: 16641448]
  34. J Virol. 2006 Dec;80(24):12293-302 [PMID: 17005664]
  35. Neuropathol Appl Neurobiol. 2009 Jun;35(3):296-305 [PMID: 19473296]
  36. J Mol Biol. 1972 Oct 14;70(3):567-87 [PMID: 5083149]
  37. Vaccine. 2008 Jul 23;26(31):3842-52 [PMID: 18556094]
  38. J Comp Pathol. 2002 Feb-Apr;126(2-3):124-36 [PMID: 11945001]
  39. Sci Signal. 2008 Apr 15;1(15):re2 [PMID: 18413883]
  40. Glycobiology. 2012 Apr;22(4):572-84 [PMID: 22171062]
  41. PLoS Pathog. 2010 Oct 28;6(10):e1001168 [PMID: 21060819]
  42. J Virol. 2006 Oct;80(19):9837-49 [PMID: 16973588]
  43. Virology. 2008 Mar 15;372(2):357-71 [PMID: 18054977]
  44. J Virol. 2011 Aug;85(15):7658-71 [PMID: 21593160]
  45. Vet J. 2009 Sep;181(3):211-20 [PMID: 19084436]
  46. Microbes Infect. 2001 Apr;3(4):315-22 [PMID: 11334749]
  47. J Virol. 2005 Jun;79(12):7528-34 [PMID: 15919907]
  48. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14920-5 [PMID: 21873198]
  49. Vet Res. 2010 May-Jun;41(3):33 [PMID: 20167195]
  50. Virology. 2009 May 10;387(2):459-65 [PMID: 19328514]
  51. J Virol. 2004 Jan;78(2):834-40 [PMID: 14694115]
  52. J Virol. 2010 Oct;84(19):9831-9 [PMID: 20660198]
  53. J Virol. 2006 Feb;80(4):1972-8 [PMID: 16439553]
  54. Vet Pathol. 1997 Jul;34(4):323-9 [PMID: 9240841]
  55. Aust Vet J. 1995 Jul;72(7):278-9 [PMID: 8534238]
  56. J Virol. 2009 Nov;83(22):11979-82 [PMID: 19759137]
  57. Emerg Infect Dis. 2009 Aug;15(8):1229-35 [PMID: 19751584]
  58. Am J Pathol. 2003 Nov;163(5):2127-37 [PMID: 14578210]
  59. Science. 1995 Apr 7;268(5207):94-7 [PMID: 7701348]
  60. Cell. 2008 Apr 4;133(1):38-52 [PMID: 18394988]
  61. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10652-7 [PMID: 15998730]
  62. Aust Vet J. 2011 Jul;89(7):N2-3 [PMID: 21834199]
  63. Emerg Infect Dis. 2010 Mar;16(3):507-10 [PMID: 20202432]
  64. J Gen Virol. 2010 Mar;91(Pt 3):765-72 [PMID: 19889926]
  65. PLoS One. 2010 May 18;5(5):e10690 [PMID: 20502528]
  66. Epidemiol Infect. 2010 Nov;138(11):1630-6 [PMID: 20380769]
  67. Virology. 2001 Nov 10;290(1):121-35 [PMID: 11882997]
  68. Aust Vet J. 1996 Aug;74(2):132-4 [PMID: 8894019]

Grants

  1. R01 AI054715/NIAID NIH HHS
  2. U01 AI077995/NIAID NIH HHS
  3. AI077995/NIAID NIH HHS
  4. AI054715/NIAID NIH HHS

MeSH Term

Animals
Antiviral Agents
Disease Outbreaks
Henipavirus
Henipavirus Infections
Humans

Chemicals

Antiviral Agents

Word Cloud

Created with Highcharts 10.0.0virusdiseasehenipavirushenipavirusesHendraNipahclassicexamplesrecentlyemergedviralzoonosesrelativelyshorttimesincediscoveriesmidlate1990srespectivelygreatdealnewinformationaccumulateddetailingbiologycertainuniquecharacteristicsbroadspeciestropismabilitiescausesevereoftenfatalrespiratoryand/orneurologicanimalshumanssparkedconsiderableinterestdevelopingeffectiveantiviralstrategiespreventtreatinfectionrecentfindingsadvancedcountermeasuressummarizeddiscussedHenipavirusoutbreaksantivirals:currentstatuspotentialtherapeutics

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