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Journal of the American Chemical Society
May 02, 2012;134 (17): 7309-12.

Hybrid semiconducting polymer dot-quantum dot with narrow-band emission, near-infrared fluorescence, and high brightness.

Yang-Hsiang Chan, Fangmao Ye, Maria Elena Gallina, Xuanjun Zhang, Yuhui Jin, I-Che Wu, Daniel T Chiu
Author Information
  1. Yang-Hsiang Chan: Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
PMID: 22515545 DOI: 10.1021/ja3022973

Abstract

This communication describes a new class of semiconducting polymer nanoparticle-quantum dot hybrid with high brightness, narrow emission, near-IR fluorescence, and excellent cellular targeting capability. Using this approach, we circumvented the current difficulty with obtaining narrow-band-emitting and near-IR-fluorescing semiconducting polymer nanoparticles while combining the advantages of both semiconducting polymer nanoparticles and quantum dots. We further demonstrated the use of this new class of hybrid nanomaterial for effective and specific cellular and subcellular labeling without any noticeable nonspecific binding. This hybrid nanomaterial is anticipated to find use in a variety of in vitro and in vivo biological applications.

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Grants

  1. R01 NS062725/NINDS NIH HHS
  2. R21 CA147831/NCI NIH HHS
  3. CA147831/NCI NIH HHS
  4. NS 062725/NINDS NIH HHS

MeSH Term

Fluorescence
Fluorescent Dyes
HeLa Cells
Humans
Microscopy, Confocal
Nanoparticles
Polymers
Quantum Dots
Semiconductors

Chemicals

Fluorescent Dyes
Polymers
Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.
Article has an altmetric score of 10

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