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Annals of biomedical engineering
Nov, 2012;40 (11): 2295-306.

Structural systems biology and multiscale signaling models.

Shannon E Telesco, Ravi Radhakrishnan
Author Information
  1. Shannon E Telesco: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
PMID: 22539148 DOI: 10.1007/s10439-012-0576-6

Abstract

We review current advances in experimental as well as computational modeling and simulation approaches to structural systems biology, whose overall aim is to build quantitative models of signaling networks while retaining the crucial elements of molecular specificity. We briefly discuss the current and emerging experimental and computational methods, particularly focusing on hybrid and multiscale methods, and highlight several applications in cell signaling with quantitative and predictive capabilities. The scope of such models range from delineating protein-protein interactions to describing clinical implications.

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Grants

  1. T32 HL007954/NHLBI NIH HHS
  2. 2T32HL007954/NHLBI NIH HHS

MeSH Term

Computer Simulation
Humans
Models, Biological
Signal Transduction
Systems Biology
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Word Cloud

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