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Nature genetics
Sep, 2012;44 (9): 1051-5.

Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade.

Shin-Ichiro Tachibana, Steven A Sullivan, Satoru Kawai, Shota Nakamura, Hyunjae R Kim, Naohisa Goto, Nobuko Arisue, Nirianne M Q Palacpac, Hajime Honma, Masanori Yagi, Takahiro Tougan, Yuko Katakai, Osamu Kaneko, Toshihiro Mita, Kiyoshi Kita, Yasuhiro Yasutomi, Patrick L Sutton, Rimma Shakhbatyan, Toshihiro Horii, Teruo Yasunaga, John W Barnwell, Ananias A Escalante, Jane M Carlton, Kazuyuki Tanabe
Author Information
  1. Shin-Ichiro Tachibana: Laboratory of Malariology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
PMID: 22863735 DOI: 10.1038/ng.2375

Abstract

P. cynomolgi, a malaria-causing parasite of Asian Old World monkeys, is the sister taxon of P. vivax, the most prevalent malaria-causing species in humans outside of Africa. Because P. cynomolgi shares many phenotypic, biological and genetic characteristics with P. vivax, we generated draft genome sequences for three P. cynomolgi strains and performed genomic analysis comparing them with the P. vivax genome, as well as with the genome of a third previously sequenced simian parasite, Plasmodium knowlesi. Here, we show that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes. We identify genome-wide SNPs, microsatellites and CNVs in the P. cynomolgi genome, providing a map of genetic variation that can be used to map parasite traits and study parasite populations. The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax.

Associated Data

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Grants

  1. U19 AI089676/United States
  2. S10 RR026950/United States
  3. U19 AI089676-01/United States
  4. R01 GM070793/United States
  5. R01 GM080586/United States

MeSH Term

Animals
Base Sequence
Cluster Analysis
Genes, Protozoan
Genome, Protozoan
Haplorhini
Malaria
Models, Genetic
Molecular Sequence Data
Monkey Diseases
Phylogeny
Plasmodium cynomolgi
Plasmodium vivax
Sequence Analysis, DNA
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
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