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Journal of bioenergetics and biomembranes
Dec, 2012;44 (6): 623-7.

Mitochondria in relation to cancer metastasis.

Bidur Bhandary, Anu Marahatta, Hyung-Ryong Kim, Han-Jung Chae
Author Information
  1. Bidur Bhandary: Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Korea.
PMID: 22914881 DOI: 10.1007/s10863-012-9464-x

Abstract

Mitochondria, also known as "Power House of cell," are crucial organelles, regulating energy metabolism. Recently, an involvement of mitochondria in cancer occurrence and metastasis has been proposed. The roles of mitochondria in cancer progression/metastasis include alteration of glycolysis, regulation of ROS and suppression of intrinsic apoptosis. This mini-review explains the specific mitochondrial characteristics during cancer metastasis with past and recent findings. It may contribute to understanding mitochondria-related mechanisms of cancer metastasis.

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MeSH Term

Animals
Apoptosis
Energy Metabolism
Humans
Mitochondria
Neoplasm Metastasis
Neoplasms
Reactive Oxygen Species

Chemicals

Reactive Oxygen Species
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 2

Word Cloud

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