Critical care considerations in the management of the trauma patient following initial resuscitation.

Roger F Shere-Wolfe, Samuel M Galvagno, Thomas E Grissom
Author Information
  1. Roger F Shere-Wolfe: University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, 22 S. Greene St, Ste. T1R77, Baltimore, MD 21201, USA. rsherewolf@mac.com

Abstract

BACKGROUND: Care of the polytrauma patient does not end in the operating room or resuscitation bay. The patient presenting to the intensive care unit following initial resuscitation and damage control surgery may be far from stable with ongoing hemorrhage, resuscitation needs, and injuries still requiring definitive repair. The intensive care physician must understand the respiratory, cardiovascular, metabolic, and immunologic consequences of trauma resuscitation and massive transfusion in order to evaluate and adjust the ongoing resuscitative needs of the patient and address potential complications. In this review, we address ongoing resuscitation in the intensive care unit along with potential complications in the trauma patient after initial resuscitation. Complications such as abdominal compartment syndrome, transfusion related patterns of acute lung injury and metabolic consequences subsequent to post-trauma resuscitation are presented.
METHODS: A non-systematic literature search was conducted using PubMed and the Cochrane Database of Systematic Reviews up to May 2012.
RESULTS AND CONCLUSION: Polytrauma patients with severe shock from hemorrhage and massive tissue injury present major challenges for management and resuscitation in the intensive care setting. Many of the current recommendations for "damage control resuscitation" including the use of fixed ratios in the treatment of trauma induced coagulopathy remain controversial. A lack of large, randomized, controlled trials leaves most recommendations at the level of consensus, expert opinion. Ongoing trials and improvements in monitoring and resuscitation technologies will further influence how we manage these complex and challenging patients.

References

  1. J Trauma. 1999 Nov;47(5):964-9 [PMID: 10568731]
  2. J Trauma. 2007 Feb;62(2):307-10 [PMID: 17297317]
  3. Crit Care. 2003 Feb;7(1):19-20 [PMID: 12617736]
  4. J Trauma. 2008 Oct;65(4):951-60 [PMID: 18849817]
  5. Minerva Anestesiol. 2007 Jul-Aug;73(7-8):401-15 [PMID: 17380100]
  6. Chest. 1993 Mar;103(3):886-95 [PMID: 8449087]
  7. Curr Opin Crit Care. 2009 Dec;15(6):527-35 [PMID: 19812487]
  8. Ann Intensive Care. 2011 Jul 19;1(1):27 [PMID: 21906380]
  9. J Trauma. 1988 Oct;28(10):1464-7 [PMID: 3172306]
  10. Curr Opin Anaesthesiol. 2009 Apr;22(2):150-4 [PMID: 19390244]
  11. J Trauma. 2003 May;54(5 Suppl):S52-62 [PMID: 12768104]
  12. Adv Surg. 2011;45:187-96 [PMID: 21954687]
  13. Ann Surg. 2010 Apr;251(4):604-14 [PMID: 20224372]
  14. J Trauma. 2008 Jan;64(1):9-14 [PMID: 18188092]
  15. Scand J Trauma Resusc Emerg Med. 2012 Feb 24;20:15 [PMID: 22364525]
  16. Hematology Am Soc Hematol Educ Program. 2007;:187-91 [PMID: 18024628]
  17. J Trauma. 1996 Nov;41(5):769-74 [PMID: 8913202]
  18. Lancet. 2005 Jun 4-10;365(9475):1957-9 [PMID: 15936423]
  19. World J Surg. 2002 Dec;26(12):1428-31 [PMID: 12297912]
  20. Inj Prev. 2011 Apr;17(2):108-13 [PMID: 21113015]
  21. Curr Opin Crit Care. 2010 Jun;16(3):250-4 [PMID: 20179590]
  22. Intensive Care Med. 2009 Apr;35(4):671-7 [PMID: 18936911]
  23. Am J Surg. 2006 May;191(5):610-4 [PMID: 16647346]
  24. Crit Care Med. 2008 Jul;36(7 Suppl):S267-74 [PMID: 18594252]
  25. Ann Surg. 2000 Sep;232(3):409-18 [PMID: 10973391]
  26. J Trauma. 1993 Oct;35(4):584-8; discussion 588-9 [PMID: 8411283]
  27. N Engl J Med. 2002 Feb 21;346(8):557-63 [PMID: 11856794]
  28. JPEN J Parenter Enteral Nutr. 2005 Sep-Oct;29(5):353-8; discussion 359 [PMID: 16107598]
  29. J Trauma. 1993 Sep;35(3):375-82; discussion 382-3 [PMID: 8371295]
  30. Curr Opin Crit Care. 2004 Dec;10(6):529-38 [PMID: 15616397]
  31. Lancet. 2010 Jul 3;376(9734):23-32 [PMID: 20554319]
  32. N Engl J Med. 1995 Oct 19;333(16):1025-32 [PMID: 7675044]
  33. Am J Surg. 2003 May;185(5):485-91 [PMID: 12727572]
  34. Curr Opin Crit Care. 2007 Dec;13(6):680-5 [PMID: 17975390]
  35. Am J Respir Crit Care Med. 2007 Nov 1;176(9):886-91 [PMID: 17626910]
  36. J Trauma. 2010 Oct;69(4):976-90 [PMID: 20938283]
  37. Lancet. 2004 Jun 12;363(9425):1988-96 [PMID: 15194260]
  38. J Trauma. 2003 Jul;55(1):39-44 [PMID: 12855879]
  39. Ann Surg. 1987 Feb;205(2):175-81 [PMID: 3813688]
  40. Anesth Analg. 2009 Mar;108(3):759-69 [PMID: 19224780]
  41. Crit Care Med. 1985 Feb;13(2):85-90 [PMID: 3967509]
  42. J Trauma. 2004 Oct;57(4):898-912 [PMID: 15514553]
  43. Can J Anaesth. 2004 Apr;51(4):293-310 [PMID: 15064258]
  44. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2 [PMID: 21439633]
  45. Intensive Care Med. 2007 Apr;33(4):575-90 [PMID: 17285286]
  46. Curr Opin Anaesthesiol. 2009 Apr;22(2):267-74 [PMID: 19390253]
  47. Arch Surg. 2010 Sep;145(9):899-906 [PMID: 20855762]
  48. N Engl J Med. 1996 May 9;334(19):1209-15 [PMID: 8606715]
  49. Scand J Trauma Resusc Emerg Med. 2009 Aug 13;17:35 [PMID: 19678943]
  50. Scand J Trauma Resusc Emerg Med. 2009 Dec 23;17:65 [PMID: 20030810]
  51. J Trauma. 2010 Dec;69(6):1427-31; discussion 1431-2 [PMID: 21150522]
  52. J Trauma. 1987 Sep;27(9):1019-24 [PMID: 3656464]
  53. J Trauma. 2000 Apr;48(4):613-21; discussion 621-3 [PMID: 10780592]
  54. J Trauma. 2010 Jul;69 Suppl 1:S69-74 [PMID: 20622623]
  55. Injury. 2012 Feb;43(2):196-9 [PMID: 21741649]
  56. J Trauma. 1997 May;42(5):857-61; discussion 861-2 [PMID: 9191667]
  57. J Trauma. 1996 Jul;41(1):32-9; discussion 39-40 [PMID: 8676421]
  58. JAMA. 2011 Mar 23;305(12):1201-9 [PMID: 21427372]
  59. Curr Opin Anaesthesiol. 2011 Apr;24(2):202-8 [PMID: 21293262]
  60. J Trauma. 1992 Jan;32(1):2-11 [PMID: 1732568]
  61. Transfusion. 2006 Sep;46(9):1478-83 [PMID: 16965572]
  62. J Crit Care. 1994 Mar;9(1):72-81 [PMID: 8199655]
  63. Crit Care Med. 1994 Apr;22(4):633-9 [PMID: 8143473]
  64. Ann Surg. 2012 Apr;255(4):789-95 [PMID: 22388109]
  65. J Trauma. 1998 Aug;45(2):291-301; discussion 301-3 [PMID: 9715186]
  66. Transfusion. 2009 Jan;49(1):2-4 [PMID: 19140808]
  67. Crit Care. 2010;14(1):202 [PMID: 20156316]
  68. Crit Care Med. 2006 Feb;34(2):403-8 [PMID: 16424721]
  69. Am Surg. 2011 Jul;77 Suppl 1:S12-6 [PMID: 21944446]
  70. Shock. 2010 Feb;33(2):113-22 [PMID: 20081495]
  71. Respir Care. 2004 Feb;49(2):192-205 [PMID: 14744270]
  72. Br J Surg. 2011 Jul;98(7):894-907 [PMID: 21509749]
  73. Arch Surg. 1992 Oct;127(10):1175-9; discussion 1179-81 [PMID: 1417482]
  74. Transfusion. 2005 Sep;45(9):1413-25 [PMID: 16131373]
  75. J Emerg Trauma Shock. 2011 Jul;4(3):359-64 [PMID: 21887026]
  76. J Trauma. 2011 Nov;71(5 Suppl 1):S435-40 [PMID: 22072000]
  77. Am J Clin Pathol. 2006 Jul;126(1):133-9 [PMID: 16753596]
  78. Anesth Analg. 2011 Nov;113(5):1003-12 [PMID: 21918164]
  79. J Trauma. 1998 May;44(5):908-14 [PMID: 9603098]
  80. Transfusion. 2009 Dec;49(12):2652-60 [PMID: 19682336]
  81. Crit Care Med. 2005 Jun;33(6):1191-8 [PMID: 15942330]
  82. Med Hypotheses. 2010 Dec;75(6):564-7 [PMID: 20708846]
  83. Ann Surg. 2007 May;245(5):812-8 [PMID: 17457176]
  84. J Trauma. 2002 Oct;53(4):679-85 [PMID: 12394866]
  85. Ann Surg. 2009 May;249(5):845-50 [PMID: 19387315]
  86. J Trauma. 1995 May;38(5):780-7 [PMID: 7760409]
  87. J Trauma. 2000 Nov;49(5):969-78 [PMID: 11086798]
  88. J Trauma. 2009 Jan;66(1):41-8; discussion 48-9 [PMID: 19131804]
  89. Chest. 1988 Dec;94(6):1176-86 [PMID: 3191758]
  90. Shock. 2007 Apr;27(4):380-9 [PMID: 17414420]
  91. Crit Care Med. 2010 Sep;38(9 Suppl):S411-20 [PMID: 20724874]
  92. Am Surg. 2011 Jul;77 Suppl 1:S31-3 [PMID: 21944449]
  93. World J Surg. 2009 Apr;33(4):864-9 [PMID: 19219493]
  94. Surg Clin North Am. 2000 Jun;80(3):845-54 [PMID: 10897264]
  95. Anesth Analg. 2011 Oct;113(4):711-2 [PMID: 21788315]
  96. Ann Surg. 1997 Oct;226(4):439-47; discussion 447-9 [PMID: 9351712]
  97. World J Surg. 2011 Feb;35(2):430-9 [PMID: 21161222]
  98. Transfus Med Rev. 2010 Apr;24(2):77-124 [PMID: 20303034]
  99. J Am Soc Nephrol. 2011 Apr;22(4):615-21 [PMID: 21310818]
  100. Arch Surg. 2010 Oct;145(10):973-7 [PMID: 20956766]
  101. J Trauma. 1998 Sep;45(3):470-8 [PMID: 9751535]
  102. J Trauma. 2007 Jun;62(6 Suppl):S56-7 [PMID: 17556975]
  103. Am Surg. 2006 Jun;72(6):552-4 [PMID: 16808213]
  104. Scand J Trauma Resusc Emerg Med. 2012 Feb 03;20:12 [PMID: 22304785]
  105. Transfusion. 1995 Mar;35(3):199-203 [PMID: 7878710]
  106. Arch Surg. 2003 Jun;138(6):637-42; discussion 642-3 [PMID: 12799335]
  107. Ren Fail. 1997 Sep;19(5):647-53 [PMID: 9380883]
  108. Scand J Trauma Resusc Emerg Med. 2009 Mar 02;17:10 [PMID: 19254364]
  109. J Trauma. 2002 Nov;53(5):825-32 [PMID: 12435930]
  110. J Trauma. 2007 Jan;62(1):112-9 [PMID: 17215741]
  111. Am J Physiol. 1985 Feb;248(2 Pt 2):R208-13 [PMID: 3918464]
  112. Transfusion. 2006 Nov;46(11):2014-27 [PMID: 17076859]
  113. Anesth Analg. 2008 Apr;106(4):1062-9, table of contents [PMID: 18349174]
  114. Surg Clin North Am. 2007 Feb;87(1):55-72, vi [PMID: 17127123]
  115. Intensive Care Med. 2010 Aug;36(8):1299-308 [PMID: 20502873]
  116. J Trauma. 2005 Sep;59(3):609-15 [PMID: 16361902]
  117. J Intensive Care Med. 2012 Mar-Apr;27(2):79-96 [PMID: 21300672]
  118. Arch Intern Med. 1988 Jul;148(7):1553-7 [PMID: 3382301]
  119. J Trauma. 2000 Jul;49(1):26-33; discussion 34-7 [PMID: 10912854]
  120. J Trauma. 2009 Aug;67(2):221-7; discussion 228-30 [PMID: 19667872]
  121. Curr Opin Hematol. 2007 Nov;14(6):682-7 [PMID: 17898575]
  122. Shock. 2006 Feb;25(2):103-16 [PMID: 16525347]
  123. Crit Care. 2004 Apr;8(2):R60-5 [PMID: 15025779]
  124. Crit Care. 2005 Apr;9(2):158-69 [PMID: 15774072]
  125. J Trauma. 2007 Mar;62(3):647-56; discussion 656 [PMID: 17414342]
  126. J Trauma. 2008 May;64(5):1211-7; discussion 1217 [PMID: 18469643]
  127. Scand J Trauma Resusc Emerg Med. 2009 Sep 23;17:45 [PMID: 19775458]
  128. Crit Care Med. 2009 Mar;37(3):1000-10 [PMID: 19237910]
  129. J Trauma. 2011 Dec;71(6):1627-31 [PMID: 21537207]
  130. Am J Surg. 1999 Dec;178(6):570-2 [PMID: 10670874]
  131. Scand J Trauma Resusc Emerg Med. 2011 Sep 28;19:52 [PMID: 21955460]
  132. Dis Mon. 2003 Jan;49(1):14-21 [PMID: 12525825]
  133. J Trauma. 1993 Feb;34(2):216-22 [PMID: 8459458]
  134. Crit Care Med. 1994 Oct;22(10):1610-5 [PMID: 7924373]
  135. Arch Surg. 1997 Jun;132(6):620-4; discussion 624-5 [PMID: 9197854]
  136. J Intern Med. 2003 Dec;254(6):517-26 [PMID: 14641792]
  137. J Trauma. 2011 Nov;71(5 Suppl 1):S448-55 [PMID: 22072002]
  138. Scand J Trauma Resusc Emerg Med. 2009 Apr 14;17:17 [PMID: 19366442]
  139. J Trauma. 2003 Jun;54(6):1127-30 [PMID: 12813333]
  140. Am J Surg. 2001 Nov;182(5):481-5 [PMID: 11754855]
  141. Injury. 2004 Jul;35(7):649-54 [PMID: 15203304]
  142. Int Anesthesiol Clin. 2002 Summer;40(3):1-17 [PMID: 12055509]
  143. JAMA. 1993 Dec 8;270(22):2699-707 [PMID: 7907668]
  144. Br J Haematol. 2009 Nov;147(4):431-43 [PMID: 19663827]
  145. Blood Coagul Fibrinolysis. 2010 Mar;21(2):168-74 [PMID: 20051844]
  146. Crit Care. 2009;13(3):R92 [PMID: 19534818]
  147. Arch Surg. 2004 Nov;139(11):1199-203 [PMID: 15545567]
  148. J Trauma Acute Care Surg. 2012 Feb;72(2):428-36 [PMID: 22439205]
  149. Crit Care. 2005;9 Suppl 4:S20-6 [PMID: 16168070]
  150. Intensive Care Med. 2006 Nov;32(11):1722-32 [PMID: 16967294]
  151. Ann Intern Med. 2011 Apr 19;154(8):529-40 [PMID: 21502651]
  152. Blood Rev. 2007 Nov;21(6):327-48 [PMID: 17804128]
  153. J Trauma. 2008 Aug;65(2):279-82; discussion 282-4 [PMID: 18695462]
  154. Anesthesiol Clin. 2007 Mar;25(1):23-34, viii [PMID: 17400153]
  155. J Trauma. 2009 Jul;67(1):125-31 [PMID: 19590321]
  156. Injury. 2009 Nov;40 Suppl 4:S27-35 [PMID: 19895950]
  157. Arch Neurol. 2002 Jul;59(7):1077-83 [PMID: 12117354]
  158. Transfus Med Rev. 2004 Jul;18(3):184-8 [PMID: 15248168]
  159. Br J Haematol. 2007 Mar;136(6):788-99 [PMID: 17341264]
  160. Transfusion. 2012 Jan;52(1):160-5 [PMID: 21762464]
  161. Crit Care Med. 1996 Mar;24(3):517-24 [PMID: 8625644]
  162. Crit Care Med. 1993 Jan;21(1):56-63 [PMID: 8420731]
  163. Am J Respir Crit Care Med. 2010 Sep 15;182(6):752-61 [PMID: 20463176]

MeSH Term

Blood Coagulation Disorders
Critical Care
Humans
Intensive Care Units
Multiple Trauma
Resuscitation
Shock, Hemorrhagic
Transfusion Reaction

Word Cloud

Created with Highcharts 10.0.0resuscitationpatientcareintensivetraumainitialongoingunitfollowingcontrolhemorrhageneedsmetabolicconsequencesmassivetransfusionaddresspotentialcomplicationsinjurypatientsmanagementrecommendationstrialsBACKGROUND:CarepolytraumaendoperatingroombaypresentingdamagesurgerymayfarstableinjuriesstillrequiringdefinitiverepairphysicianmustunderstandrespiratorycardiovascularimmunologicorderevaluateadjustresuscitativereviewalongComplicationsabdominalcompartmentsyndromerelatedpatternsacutelungsubsequentpost-traumapresentedMETHODS:non-systematicliteraturesearchconductedusingPubMedCochraneDatabaseSystematicReviewsMay2012RESULTSANDCONCLUSION:PolytraumasevereshocktissuepresentmajorchallengessettingManycurrent"damageresuscitation"includingusefixedratiostreatmentinducedcoagulopathyremaincontroversiallacklargerandomizedcontrolledleaveslevelconsensusexpertopinionOngoingimprovementsmonitoringtechnologieswillinfluencemanagecomplexchallengingCriticalconsiderations

Similar Articles

Cited By