OpenLB
Open Library of Bioscience
Advanced Search
Advances in genetics
2012;80 37-97.

Precision editing of large animal genomes.

Wenfang Spring Tan, Daniel F Carlson, Mark W Walton, Scott C Fahrenkrug, Perry B Hackett
Author Information
  1. Wenfang Spring Tan: Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
PMID: 23084873 DOI: 10.1016/B978-0-12-404742-6.00002-8

Abstract

Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.

References

  1. ILAR J. 2009;50(2):122-7 [PMID: 19293457]
  2. Nat Rev Genet. 2003 Oct;4(10):825-33 [PMID: 14526378]
  3. Nature. 2005 Jun 2;435(7042):646-51 [PMID: 15806097]
  4. Science. 2009 Dec 11;326(5959):1509-12 [PMID: 19933107]
  5. Science. 2010 Nov 19;330(6007):1052-3 [PMID: 21097923]
  6. Science. 2012 Feb 10;335(6069):716-9 [PMID: 22223736]
  7. Brief Funct Genomic Proteomic. 2002 Jul;1(2):119-30 [PMID: 15239898]
  8. Sci China Life Sci. 2010 Apr;53(4):517-23 [PMID: 20596920]
  9. Nat Biotechnol. 2011 Aug 05;29(8):699-700 [PMID: 21822242]
  10. Mol Reprod Dev. 1989;1(3):164-9 [PMID: 2516725]
  11. Nature. 2000 Jun 29;405(6790):1066-9 [PMID: 10890449]
  12. Mar Biotechnol (NY). 2003 Mar-Apr;5(2):174-84 [PMID: 12876654]
  13. Virology. 1994 May 1;200(2):370-80 [PMID: 8178428]
  14. Biotechnology (N Y). 1991 Sep;9(9):844-7 [PMID: 1367358]
  15. Biotechnology (N Y). 1996 Feb;14(2):185-8 [PMID: 9636321]
  16. Trends Biotechnol. 2004 Jun;22(6):286-94 [PMID: 15158058]
  17. Avian Dis. 1986 Jan-Mar;30(1):43-6 [PMID: 3460568]
  18. Curr Opin Organ Transplant. 2009 Apr;14(2):148-53 [PMID: 19469029]
  19. J Anim Sci. 1985 Feb;60(2):583-92 [PMID: 3886617]
  20. Transgenic Res. 2005 Oct;14(5):761-73 [PMID: 16245167]
  21. Nat Biotechnol. 2011 Apr;29(4):302 [PMID: 21478839]
  22. Nat Biotechnol. 2005 Aug;23(8):967-73 [PMID: 16082368]
  23. Nat Biotechnol. 2001 Aug;19(8):741-5 [PMID: 11479566]
  24. Trends Genet. 1999 Aug;15(8):326-32 [PMID: 10431195]
  25. Gene. 1991 Feb 15;98(2):185-91 [PMID: 1901821]
  26. J Endocrinol. 1989 Mar;120(3):481-8 [PMID: 2926315]
  27. Xenotransplantation. 2009 Nov-Dec;16(6):486-95 [PMID: 20042048]
  28. Xenotransplantation. 2008 Feb;15(1):36-45 [PMID: 18333912]
  29. Genome Biol. 2012;13(4):244 [PMID: 22546202]
  30. Biol Reprod. 2003 Aug;69(2):437-45 [PMID: 12672664]
  31. Nature. 2010 Oct 28;467(7319):1061-73 [PMID: 20981092]
  32. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17382-7 [PMID: 23027955]
  33. Genome Biol. 2011 Sep 14;12(9):R84 [PMID: 21917140]
  34. Mol Ther. 2006 Jan;13(1):59-66 [PMID: 16140581]
  35. Mol Reprod Dev. 2009 Jan;76(1):3 [PMID: 18951376]
  36. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1696-700 [PMID: 1705703]
  37. Transgenic Res. 2011 Feb;20(1):29-45 [PMID: 20352328]
  38. Nat Biotechnol. 2001 Jun;19(6):559-62 [PMID: 11385461]
  39. Nucleic Acids Res. 2011 Jul;39(12):e82 [PMID: 21493687]
  40. PLoS One. 2012;7(5):e36658 [PMID: 22590584]
  41. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4730-7 [PMID: 22315419]
  42. Nat Biotechnol. 2007 Jul;25(7):778-85 [PMID: 17603475]
  43. Nat Rev Genet. 2010 Sep;11(9):636-46 [PMID: 20717154]
  44. Int J Biol Sci. 2007 Feb 10;3(3):179-84 [PMID: 17384736]
  45. PLoS One. 2012;7(4):e35335 [PMID: 22536374]
  46. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2623-8 [PMID: 21262818]
  47. Transgenic Res. 2011 Apr;20(2):417-9 [PMID: 20549346]
  48. Thromb Haemost. 1997 Jul;78(1):537-42 [PMID: 9198211]
  49. Xenotransplantation. 2009 Nov-Dec;16(6):477-85 [PMID: 20042047]
  50. ILAR J. 2009;50(2):107-11 [PMID: 19293455]
  51. PLoS One. 2011 Feb 18;6(2):e16765 [PMID: 21364738]
  52. J Reprod Fertil Suppl. 1990;41:199-208 [PMID: 2213711]
  53. FASEB J. 2006 Jun;20(8):1200-2 [PMID: 16684801]
  54. Nat Biotechnol. 2012 May;30(5):460-5 [PMID: 22484455]
  55. Xenotransplantation. 2009 May-Jun;16(3):164-80 [PMID: 19566656]
  56. Nat Biotechnol. 2011 Feb;29(2):143-8 [PMID: 21179091]
  57. Eur J Immunol. 1991 Apr;21(4):1001-6 [PMID: 2019284]
  58. Genetics. 2010 Oct;186(2):757-61 [PMID: 20660643]
  59. Trends Biotechnol. 2003 Jan;21(1):14-9 [PMID: 12480346]
  60. Exp Anim. 2001 Apr;50(2):125-31 [PMID: 11381615]
  61. BMC Biotechnol. 2007 Jul 17;7:42 [PMID: 17640337]
  62. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6127-33 [PMID: 20194732]
  63. Cell. 1983 Dec;35(3 Pt 2):647-55 [PMID: 6580963]
  64. J Anim Sci. 1991 Nov;69(11):4552-62 [PMID: 1721617]
  65. Mol Endocrinol. 1988 Mar;2(3):277-83 [PMID: 3398854]
  66. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12013-7 [PMID: 21730124]
  67. Transgenic Res. 2003 Aug;12(4):485-96 [PMID: 12885169]
  68. Transgenic Res. 2001 Dec;10(6):577-82 [PMID: 11817545]
  69. Proc Natl Acad Sci U S A. 1973 Nov;70(11):3240-4 [PMID: 4594039]
  70. Experientia. 1991 Sep 15;47(9):913-22 [PMID: 1915775]
  71. J Gen Virol. 2006 Apr;87(Pt 4):1019-1027 [PMID: 16528053]
  72. J Anim Sci. 2010 Jul;88(7):2530-9 [PMID: 20228236]
  73. J Cell Sci. 1988 Jun;90 ( Pt 2):295-300 [PMID: 3246521]
  74. Nat Methods. 2011 Jan;8(1):74-9 [PMID: 21131970]
  75. Curr Gene Ther. 2011 Feb;11(1):2-10 [PMID: 21182468]
  76. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11153-7 [PMID: 7526391]
  77. Annu Rev Biochem. 2010;79:213-31 [PMID: 20192761]
  78. J Dairy Sci. 2009 Jun;92(6):2931-46 [PMID: 19448026]
  79. PLoS One. 2011;6(5):e19986 [PMID: 21603633]
  80. J Allergy Clin Immunol. 2005 Oct;116(4):876-83 [PMID: 16210064]
  81. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6361-6 [PMID: 15067141]
  82. Nat Biotechnol. 2007 Jan;25(1):132-8 [PMID: 17195841]
  83. Nature. 2012 May 02;485(7399):494-7 [PMID: 22622576]
  84. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12834-9 [PMID: 8917505]
  85. Nat Biotechnol. 2006 Apr;24(4):435-6 [PMID: 16565727]
  86. J Anim Sci. 1999 Jul;77(7):1686-92 [PMID: 10438013]
  87. Transgenic Res. 1995 Nov;4(6):369-77 [PMID: 7581517]
  88. Science. 1974 Jul 26;185(4148):303 [PMID: 4600381]
  89. Mol Ther Nucleic Acids. 2012 Jan 24;1:e3 [PMID: 23344620]
  90. Nature. 1985 Jun 20-26;315(6021):680-3 [PMID: 3892305]
  91. Cell. 1981 Nov;27(1 Pt 2):223-31 [PMID: 6276022]
  92. PLoS One. 2011;6(8):e23573 [PMID: 21897845]
  93. Biol Reprod. 1994 Mar;50(3):664-8 [PMID: 8167238]
  94. Nat Biotechnol. 2003 Oct;21(10):1208-14 [PMID: 12960965]
  95. Proc Natl Acad Sci U S A. 2004 May 4;101(18):6858-63 [PMID: 15105446]
  96. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4495-9 [PMID: 11904379]
  97. Nat Biotechnol. 2009 Sep;27(9):851-7 [PMID: 19680244]
  98. Theriogenology. 2003 Feb;59(3-4):831-9 [PMID: 12517386]
  99. PLoS Genet. 2010 Sep 09;6(9):e1001111 [PMID: 20838461]
  100. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):E1466-72 [PMID: 22586100]
  101. Cell. 1997 Nov 14;91(4):501-10 [PMID: 9390559]
  102. Science. 1989 Jun 16;244(4910):1281-8 [PMID: 2499927]
  103. Transgenic Res. 2011 Jun;20(3):625-41 [PMID: 20872248]
  104. Science. 2009 Dec 11;326(5959):1501 [PMID: 19933106]
  105. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20260-4 [PMID: 22106295]
  106. Biol Reprod. 2003 Sep;69(3):995-1001 [PMID: 12773418]
  107. Nature. 1985 Sep 19-25;317(6034):230-4 [PMID: 2995814]
  108. Transgenic Res. 2011 Jun;20(3):533-45 [PMID: 20803249]
  109. Transplantation. 2006 Mar 15;81(5):760-6 [PMID: 16534480]
  110. Mol Reprod Dev. 2009 May;76(5):490-500 [PMID: 19090011]
  111. Mol Ther. 2006 Jul;14(1):5-13 [PMID: 16698321]
  112. J Gene Med. 2004 May;6(5):481-506 [PMID: 15133760]
  113. Transgenic Res. 2012 Jun;21(3):605-18 [PMID: 22038447]
  114. Mol Reprod Dev. 2002 Jul;62(3):300-6 [PMID: 12112592]
  115. Science. 2002 Feb 8;295(5557):1089-92 [PMID: 11778012]
  116. Science. 1988 Jun 10;240(4858):1468-74 [PMID: 3287623]
  117. Mech Dev. 2004 Sep;121(9):1179-86 [PMID: 15296981]
  118. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1156-60 [PMID: 8577732]
  119. Transplant Proc. 2001 Feb-Mar;33(1-2):742-3 [PMID: 11267048]
  120. Nature. 1982 Dec 16;300(5893):611-5 [PMID: 6958982]
  121. J Biotechnol. 2006 Apr 10;122(3):362-71 [PMID: 16460825]
  122. Science. 2003 May 2;300(5620):764 [PMID: 12730594]
  123. Pediatr Res. 1984 Oct;18(10):980-4 [PMID: 6436780]
  124. Vet Immunol Immunopathol. 1987 Dec;17(1-4):303-12 [PMID: 3481144]
  125. Science. 1997 Dec 19;278(5346):2130-3 [PMID: 9405350]
  126. Anim Biotechnol. 2004 May;15(1):33-45 [PMID: 15248599]
  127. Nat Biotechnol. 2011 Feb;29(2):149-53 [PMID: 21248753]
  128. J Anim Sci. 1991 Jul;69(7):2995-3004 [PMID: 1715850]
  129. Science. 2003 Jan 17;299(5605):411-4 [PMID: 12493821]
  130. Plant Physiol. 2000 Oct;124(2):487-90 [PMID: 11027697]
  131. Protein Eng Des Sel. 2011 Jan;24(1-2):27-31 [PMID: 21047873]
  132. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6064-8 [PMID: 8016116]
  133. Science. 1981 Dec 11;214(4526):1244-6 [PMID: 6272397]
  134. Mol Reprod Dev. 2011 Jan;78(1):2 [PMID: 21268178]
  135. BMC Biotechnol. 2002 Apr 19;2:5 [PMID: 11964188]
  136. Science. 2010 Oct 8;330(6001):222-5 [PMID: 20929774]
  137. Nucleic Acids Res. 2011 Jul;39(13):5790-9 [PMID: 21421566]
  138. Biol Reprod. 2002 Nov;67(5):1488-92 [PMID: 12390880]
  139. J Reprod Fertil Suppl. 1990;41:89-96 [PMID: 2213719]
  140. Curr Opin HIV AIDS. 2011 Jan;6(1):74-9 [PMID: 21242897]
  141. J Biotechnol. 2006 Jul 13;124(2):469-72 [PMID: 16716426]
  142. Mol Reprod Dev. 2012 Mar;79(3):176-85 [PMID: 22139943]
  143. Nat Biotechnol. 2011 Aug 05;29(8):695-6 [PMID: 21822240]
  144. Nat Genet. 2004 Jul;36(7):775-80 [PMID: 15184897]
  145. Genetics. 2010 Oct;186(2):451-9 [PMID: 20628038]
  146. Nucleic Acids Res. 2010 Aug;38(15):e152 [PMID: 20530528]
  147. Cell Res. 2011 Jun;21(6):979-82 [PMID: 21502977]
  148. Nat Biotechnol. 2012 Mar 07;30(3):215-7 [PMID: 22398610]
  149. Nat Biotechnol. 2003 Feb;21(2):157-62 [PMID: 12548290]
  150. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15022-6 [PMID: 20686113]
  151. Transgenic Res. 2011 Oct;20(5):1125-37 [PMID: 21221779]
  152. Nat Methods. 2009 Jun;6(6):415-22 [PMID: 19478801]
  153. Annu Rev Phytopathol. 2010;48:419-36 [PMID: 19400638]
  154. PLoS One. 2008;3(10):e3453 [PMID: 18941633]
  155. J Reprod Dev. 2008 Jun;54(3):156-63 [PMID: 18296867]
  156. Cell. 2010 Nov 24;143(5):837-47 [PMID: 21111241]
  157. Hum Mol Genet. 2010 Oct 15;19(20):3983-94 [PMID: 20660116]
  158. Genome Res. 2012 Apr;22(4):778-90 [PMID: 22300768]
  159. Transgenic Res. 2001;10(1):43-51 [PMID: 11252382]
  160. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7380-4 [PMID: 6261253]
  161. Nature. 1988 Nov 24;336(6197):348-52 [PMID: 3194019]
  162. Science. 1983 Nov 18;222(4625):809-14 [PMID: 6356363]
  163. Methods Cell Biol. 2011;104:51-8 [PMID: 21924156]
  164. Nat Biotechnol. 2007 Jul;25(7):786-93 [PMID: 17603476]
  165. Transgenic Res. 2001 Dec;10(6):523-31 [PMID: 11817540]
  166. Nucleic Acids Res. 2011 Jun;39(11):4680-90 [PMID: 21321018]
  167. Transpl Int. 2005 Aug;18(8):894-901 [PMID: 16008737]
  168. Nature. 2011 Oct 12;478(7369):337-42 [PMID: 21993620]
  169. EMBO Mol Med. 2011 Feb;3(2):75-7 [PMID: 21254403]
  170. Nature. 2003 Nov 27;426(6965):372 [PMID: 14647345]
  171. Science. 2010 Feb 12;327(5967):812-8 [PMID: 20110467]
  172. Nat Methods. 2011 Aug 30;8(9):725-6 [PMID: 21878917]
  173. Biotechnology (N Y). 1992 May;10(5):557-9 [PMID: 1368235]
  174. J Anim Sci. 1997 Aug;75(8):2208-14 [PMID: 9263070]
  175. Mol Cell. 2008 Jul 25;31(2):294-301 [PMID: 18657511]
  176. Reprod Fertil Dev. 2004;16(4):465-70 [PMID: 15315745]
  177. J Mol Med (Berl). 2008 Nov;86(11):1205-19 [PMID: 18607557]
  178. Science. 1992 Aug 21;257(5073):1083-8 [PMID: 1380723]
  179. Nat Biotechnol. 2011 Aug 07;29(9):816-23 [PMID: 21822255]
  180. Genome Res. 2009 Jul;19(7):1279-88 [PMID: 19470664]
  181. Nat Biotechnol. 1997 Oct;15(10):971-5 [PMID: 9335047]
  182. Science. 2011 Sep 30;333(6051):1843-6 [PMID: 21960622]
  183. PLoS Comput Biol. 2006 Nov 24;2(11):e157 [PMID: 17166054]
  184. PLoS One. 2011;6(6):e21045 [PMID: 21695153]
  185. Science. 2001 Feb 16;291(5507):1304-51 [PMID: 11181995]
  186. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19703-8 [PMID: 18077404]
  187. Nat Biotechnol. 1999 May;17(5):456-61 [PMID: 10331804]
  188. Gene. 1992 Nov 16;121(2):263-70 [PMID: 1446823]
  189. Science. 1989 Jan 27;243(4890):533-5 [PMID: 2536194]
  190. Nat Biotechnol. 2002 Sep;20(9):889-94 [PMID: 12172556]
  191. J Reprod Dev. 2009 Apr;55(2):128-36 [PMID: 19106487]
  192. Bioessays. 1996 Dec;18(12):993-8 [PMID: 8976156]
  193. Science. 2012 Feb 17;335(6070):823-8 [PMID: 22344438]
  194. J Reprod Dev. 2009 Oct;55(5):484-90 [PMID: 19521054]
  195. Hum Mol Genet. 2011 Apr 15;20(R1):R14-20 [PMID: 21459777]
  196. Basic Life Sci. 1986;37:285-97 [PMID: 3458460]
  197. Nucleic Acids Res. 2005 Nov 23;33(20):e178 [PMID: 16306233]
  198. Nucleic Acids Res. 2011 Aug;39(14):6315-25 [PMID: 21459844]
  199. Trends Biotechnol. 1990 Jan;8(1):6-11 [PMID: 1366571]
  200. Nat Methods. 2011 Jan;8(1):67-9 [PMID: 21151135]
  201. Anim Biotechnol. 2001 Nov;12(2):205-14 [PMID: 11808636]
  202. Biotechnology (N Y). 1991 Sep;9(9):835-8 [PMID: 1367544]
  203. Animal. 2010 May;4(5):767-71 [PMID: 22444131]
  204. Science. 2008 Sep 26;321(5897):1837-41 [PMID: 18818360]
  205. FASEB J. 2011 Sep;25(9):2855-7 [PMID: 21880667]
  206. Cloning Stem Cells. 2008 Sep;10(3):313-23 [PMID: 18729767]
  207. Nat Biotechnol. 1997 Oct;15(10):965-70 [PMID: 9335046]
  208. Mol Cell Biol. 1995 Apr;15(4):1968-73 [PMID: 7891691]
  209. Mol Ther. 2010 Jun;18(6):1200-9 [PMID: 20372108]
  210. Science. 2009 Jul 31;325(5940):578-85 [PMID: 19644114]
  211. Mol Reprod Dev. 2009 Jan;76(1):61-4 [PMID: 18449866]
  212. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9011-3 [PMID: 7568062]
  213. Cell. 1983 Sep;34(2):343-58 [PMID: 6616614]
  214. Mol Reprod Dev. 2005 Sep;72(1):68-76 [PMID: 15906394]
  215. Science. 2010 Oct 8;330(6001):189-90 [PMID: 20929767]
  216. Transgenic Res. 1999 Jun;8(3):237-47 [PMID: 10478493]
  217. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14028-33 [PMID: 9826647]
  218. Reprod Fertil Dev. 1989;1(2):147-55 [PMID: 2552507]
  219. FEBS Lett. 2004 Jul 30;571(1-3):233-6 [PMID: 15280048]
  220. Science. 1998 May 22;280(5367):1256-8 [PMID: 9596577]
  221. Nucleic Acids Res. 2011 Jan;39(1):359-72 [PMID: 20699274]
  222. J Reprod Fertil Suppl. 1989;38:153-60 [PMID: 2795560]
  223. Cell Res. 2011 Nov;21(11):1638-40 [PMID: 21912434]
  224. BMC Bioinformatics. 2010 Nov 02;11:543 [PMID: 21044337]
  225. Nucleic Acids Res. 1995 Dec 25;23(24):5012-9 [PMID: 8559659]
  226. Nat Biotechnol. 2005 Apr;23(4):445-51 [PMID: 15806099]
  227. Stem Cells Dev. 2011 Sep;20(9):1563-75 [PMID: 21126163]
  228. Genome Res. 2002 Feb;12(2):222-31 [PMID: 11827942]
  229. Mol Reprod Dev. 1995 Mar;40(3):386-90 [PMID: 7772350]
  230. Anim Genet. 2012 Oct;43(5):595-8 [PMID: 22497248]
  231. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5285-90 [PMID: 16567624]
  232. Xenotransplantation. 2009 Nov-Dec;16(6):522-34 [PMID: 20042052]
  233. Mol Reprod Dev. 2010 Mar;77(3):209-21 [PMID: 19998476]
  234. Nucleic Acids Res. 2011 May;39(10):4166-79 [PMID: 21266475]
  235. Protein Expr Purif. 2008 Feb;57(2):127-35 [PMID: 18054499]
  236. EMBO Rep. 2003 Nov;4(11):1054-60 [PMID: 14566324]
  237. Prog Clin Biol Res. 1982;85 Pt B:111-24 [PMID: 6181522]
  238. Transgenic Res. 2005 Aug;14(4):373-84 [PMID: 16201404]
  239. J Dairy Sci. 2008 Dec;91(12):4466-76 [PMID: 19038921]
  240. J Anim Sci. 1998 Dec;76(12):3072-8 [PMID: 9928612]
  241. Nat Biotechnol. 2011 Aug 05;29(8):697-8 [PMID: 21822241]
  242. Nat Methods. 2008 May;5(5):374-5 [PMID: 18446154]
  243. Transgenic Res. 2012 Apr;21(2):383-92 [PMID: 21826492]
  244. Br J Ophthalmol. 2011 Dec;95(12):1749-54 [PMID: 21873315]
  245. J Exp Med. 1911 Apr 1;13(4):397-411 [PMID: 19867421]
  246. Transgenic Res. 2006 Dec;15(6):739-50 [PMID: 17080303]
  247. Virology. 1987 Mar;157(1):236-40 [PMID: 3029962]
  248. Mol Reprod Dev. 1993 Oct;36(2):242-4 [PMID: 8257577]
  249. Am J Transplant. 2004 Sep;4(9):1383-90 [PMID: 15307825]
  250. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14230-5 [PMID: 12393815]
  251. Reproduction. 2010 Aug;140(2):259-72 [PMID: 20501790]
  252. Invest Ophthalmol Vis Sci. 2012 Jan 31;53(1):501-7 [PMID: 22247487]
  253. Biol Reprod. 2004 Aug;71(2):405-9 [PMID: 15044266]
  254. Nat Biotechnol. 2011 Aug 05;29(8):706-10 [PMID: 21822244]
  255. Biotechnology (N Y). 1994 Jun;12(6):606-8 [PMID: 7764950]
  256. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11937-42 [PMID: 11559842]
  257. Science. 2012 Feb 10;335(6069):720-3 [PMID: 22223738]
  258. J Reprod Dev. 2005 Aug;51(4):539-46 [PMID: 15947455]
  259. Transgenic Res. 1996 Jan;5(1):67-72 [PMID: 8589741]
  260. Nature. 1985 Aug 22-28;316(6030):750-2 [PMID: 4033773]
  261. Nat Rev Genet. 2011 May;12(5):363-76 [PMID: 21358748]
  262. Trends Genet. 1996 Jun;12(6):224-8 [PMID: 8928227]
  263. Genet Anal. 1999 Nov;15(3-5):155-60 [PMID: 10596756]
  264. Mol Ther. 2010 Apr;18(4):674-83 [PMID: 20104209]
  265. Transplant Proc. 2000 Nov;32(7):2505-6 [PMID: 11120269]
  266. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3047-52 [PMID: 19223591]
  267. Nature. 1980 Apr 3;284(5755):422-5 [PMID: 6987538]
  268. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2256-60 [PMID: 8460130]
  269. Mol Reprod Dev. 2005 Jul;71(3):331-8 [PMID: 15806557]
  270. Mol Ther. 2009 Sep;17(9):1537-47 [PMID: 19532134]
  271. Adv Genet. 2005;54:189-232 [PMID: 16096013]
  272. J Anim Sci. 1985;61 Suppl 3:25-37 [PMID: 3908432]
  273. Nat Biotechnol. 2002 Mar;20(3):251-5 [PMID: 11875425]
  274. Biotechnology (N Y). 1996 Feb;14(2):181-4 [PMID: 9636320]
  275. Mol Cell Biol. 2001 Jan;21(1):289-97 [PMID: 11113203]
  276. Cell. 2010 Jun 25;141(7):1253-61 [PMID: 20603005]
  277. PLoS Biol. 2004 Aug;2(8):E234 [PMID: 15314653]
  278. Science. 2003 May 2;300(5620):763 [PMID: 12730593]
  279. Nat Biotechnol. 2011 Jul 07;29(8):731-4 [PMID: 21738127]
  280. J Dairy Sci. 2011 Dec;94(12):6153-61 [PMID: 22118103]
  281. Transgenic Res. 2010 Dec;19(6):977-86 [PMID: 20135222]
  282. Lancet. 2003 Aug 16;362(9383):557-9 [PMID: 12932390]
  283. Biochem Biophys Res Commun. 2001 Aug 24;286(3):456-63 [PMID: 11511080]
  284. Transgenic Res. 2011 Jun;20(3):643-53 [PMID: 20872247]
  285. Nature. 2002 Dec 5;420(6915):520-62 [PMID: 12466850]
  286. Nat Methods. 2011 Aug 07;8(9):765-70 [PMID: 21822273]
  287. Nucleic Acids Res. 2011 Nov;39(21):9283-93 [PMID: 21813459]

Grants

  1. 1R01DK082516/NIDDK NIH HHS
  2. R01 DK082516/NIDDK NIH HHS
  3. 1R41HL108440/NHLBI NIH HHS
  4. 1R43 RR033149/NCRR NIH HHS
  5. P01HD32652/NICHD NIH HHS
  6. R41 HL108440/NHLBI NIH HHS
  7. P01 HD032652/NICHD NIH HHS

MeSH Term

Animals
Animals, Domestic
Animals, Genetically Modified
Disease Models, Animal
Food Supply
Genetic Engineering
Genome
Humans
Meat
Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review
Article has an altmetric score of 17

Word Cloud

Created with Highcharts 10.0.0willdevelopmentanimalsfoodgenomesenhancePrecisionTransgenicimportantsourceproteinnutritionhumansplaykeyrolessatisfyingincreasingdemandever-increasingworldpopulationpastdecadeexperiencedrevolutionmethodspermitintroductionspecificalterationscomplexprecisiongenome-basedimprovementfarmproductiongeneticsalsotherapeuticbiomaterialsmodelshumandiseaseresourcesadvancedpatienttherapieseditinglargeanimal

Similar Articles

Cited By